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Gene · 10133

OPTN: optineurin

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. OPTN: optineurin. Genes, record 10133. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/10133

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
OPTN
HGNC
Name
optineurin
HGNC
NCBI Gene ID
10133
NCBI Gene
HGNC ID
HGNC:17142
HGNC
Ensembl
ENSG00000123240
NCBI Gene
Aliases
ALS12, FIP-2, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96CV9Optineurin57714Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026094866 A2026-06-101Q96CV9Espacenet
EP 4650780 A22025-11-192154Q96CV9Espacenet
EP 4641201 A22025-10-291724Q96CV9Espacenet
JP 2025517969 A2025-06-121724Q96CV9Espacenet
JP 2025517970 A2025-06-122154Q96CV9Espacenet
EP 4491229 A22025-01-15159Q96CV9Espacenet
WO 2024230934 A12024-11-14284Q96CV9Espacenet
US 11446398 B22022-09-2060210Q96CV9Espacenet
US 11446398 B22022-09-2060211Q96CV9Espacenet
US 11446398 B22022-09-2060212Q96CV9Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,384

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
R01DK048370Small GTP Binding Proteins in Gastrointestinal Mucosa182025
P30EY014104P30 Core Grant for Vision Research172025
P30EY001792P30 Core Grant for Vision Research152025
P30EY005722Center Core Grant for Vision Research142025
P30CA068485Cancer Center Support Grant132025
ZIAAG000933Genetic etiology of Amyotrophic Lateral Sclerosis132025
P30DK058404Molecular and Cellular Basis for Digestive Diseases122025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions112025
R01EY022305NEIGHBORHOOD Consortium for POAG Genetics102025
P30DK020593Vanderbilt Diabetes Research Center92025

1 to 10 of 2,384Source NIH's project files

See all 2,384 nih grants

Papers4,137

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42763018PubTator, text miningPubMed
42754173PubTator, text miningPubMed
42751619PubTator, text miningPubMed
42747136PubTator, text miningPubMed
42681746PubTator, text miningPubMed
42650831PubTator, text miningPubMed
42543006PubTator, text miningPubMed
42489267PubTator, text miningPubMed
42400459PubTator, text miningPubMed
42399609PubTator, text miningPubMed

1 to 10 of 4,137

See all 4,137 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10133

GET https://conductscience.org/api/genes/v1/10133/patents?page=2