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NAMPT: nicotinamide phosphoribosyltransferase

1 protein, 185 patents, 3 drugs, 4 trials, 3,358 NIH grants and 8,796 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNAMPTHGNC
Namenicotinamide phosphoribosyltransferaseHGNC
NCBI Gene ID10135NCBI Gene
HGNC IDHGNC:30092HGNC
EnsemblENSG00000105835NCBI Gene
Aliases1110035O14Rik, PBEF, PBEF1, VF, VISFATINNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P43490Nicotinamide phosphoribosyltransferase49184Ensembl, GeneID, HGNCUniProt

Patents 185

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026526296 A2026-08-0719P43490Espacenet
US 12616713 B22026-05-056P43490Espacenet
EP 4705440 A12026-03-1119P43490Espacenet
JP 2026004568 A2026-01-1455698P43490Espacenet
JP 2025176044 A2025-12-0360P43490Espacenet
EP 4650780 A22025-11-19564P43490Espacenet
EP 4641202 A22025-10-294344P43490Espacenet
WO 2025163323 A12025-08-071P43490Espacenet
JP 2025517970 A2025-06-12564P43490Espacenet
JP 2025032204 A2025-03-1132019P43490Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DAPORINADCHEMBL566757Nicotinamide phosphoribosyltransferase inhibitorINHIBITORChEMBL
TEGLARINADCHEMBL1181731Nicotinamide phosphoribosyltransferase inhibitorINHIBITORChEMBL
TEGLARINAD CHLORIDECHEMBL190412Nicotinamide phosphoribosyltransferase inhibitorINHIBITORChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00457574TEGLARINAD CHLORIDEPHASE1ClinicalTrials.gov
NCT00435084DAPORINADPHASE1/PHASE2ClinicalTrials.gov
NCT00432107DAPORINADPHASE2ClinicalTrials.gov
NCT00431912DAPORINADPHASE2ClinicalTrials.gov

NIH grants 3358

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK056341Washington University Nutrition Obesity Research Center342,025NIH's project files
P30CA016672Cancer Center Support Grant172,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition162,025NIH's project files
P01HL126609Cytoskeletal Regulation of Lung Endothelial Pathobiology in ARDS152,025NIH's project files
R01DK098656Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and Aging152,025NIH's project files
P30DK020579Diabetes Research Center132,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
R01HL091469Cysteine oxidation in the heart122,025NIH's project files
UL1TR002345Washington University Institute of Clinical and Translational Sciences112,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)102,025NIH's project files

Papers 8796

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826315PubTator, text miningPubMed
42811977PubTator, text miningPubMed
42808265PubTator, text miningPubMed
42802277PubTator, text miningPubMed
42800593PubTator, text miningPubMed
42797409PubTator, text miningPubMed
42794507PubTator, text miningPubMed
42770008PubTator, text miningPubMed
42765029PubTator, text miningPubMed
42764882PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license