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Gene · 10148

EBI3: Epstein-Barr virus induced 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EBI3: Epstein-Barr virus induced 3. Genes, record 10148. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10148

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Gene

Symbol
EBI3
HGNC
Name
Epstein-Barr virus induced 3
HGNC
NCBI Gene ID
10148
NCBI Gene
HGNC ID
HGNC:3129
HGNC
Ensembl
ENSG00000105246
NCBI Gene
Aliases
IL-27B, IL27B, IL35B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14213Interleukin-27 subunit beta2294Ensembl, GeneID, HGNC

Source UniProt

Patents162

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026171886 A12026-08-208Q14213Espacenet
EP 4791437 A12026-08-19175Q14213Espacenet
EP 4757832 A12026-06-17444Q14213Espacenet
JP 2026016604 A2026-02-03698Q14213Espacenet
US 12534732 B22026-01-27917Q14213Espacenet
JP 2026012378 A2026-01-23917Q14213Espacenet
JP 2026502391 A2026-01-221Q14213Espacenet
JP 2026004568 A2026-01-1445165Q14213Espacenet
US 12516329 B22026-01-06917Q14213Espacenet
EP 4670792 A22025-12-31917Q14213Espacenet

1 to 10 of 162

See all 162 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,060

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEBI3 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)132025
P30CA016086Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant72025
R37CA230786Function of IL35+ B cells in pancreatic cancer62025
ZIAEY000262Role of IL-12 family cytokines in autoimmune Uveitis62025
ZIAEY000350Development of Immunologic therapies against uveitis62025
ZIAEY000372Mechanisms of immune homeostasis and regulation of intraocular inflammation62025
P30CA047904Cancer Center Support Grant52025
P30CA014520UW Comprehensive Cancer Center Support42025
R01AI051321Structure-based engineering of immune cytokine signaling42025

1 to 10 of 1,060Source NIH's project files

See all 1,060 nih grants

Papers1,901

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Discordant Interleukin-27 (IL-27) Subunit Transcription in Human Sepsis Exposes a Molecular-Attribution Gap.Biomedicines202642792776PubTator, text miningPubMed
Molecular Heterogeneity in Clinically Ambiguous Atopic Dermatitis-Psoriasis Overlap: Compartment-Resolved Transcriptomic Profiling.Allergy202642788674PubTator, text miningPubMed
Candidate proteomic indirect-effect signals linking dementia to probable muscle-bone fragility: a UK Biobank cohort study.Front Med (Lausanne)202642780496PubTator, text miningPubMed
Shifting the paradigm in bipolar disorder: moving beyond conventional inflammatory markers to novel EBI3-containing heterodimeric cytokines.Front Psychiatry202642712571PubTator, text miningPubMed
Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.Nutr Res202642579941PubTator, text miningPubMed
Free Epstein-Barr virus-induced gene 3 functions as an autonomous immunosuppressive cytokine to maintain immune tolerance.Front Immunol202642577052PubTator, text miningPubMed
Elevated cytokine and nitric oxide levels in Behçet disease: EBI-3 as a potential biomarker of vascular involvement.Immunol Lett202642144143PubTator, text miningPubMed
Metastatic adenocarcinomas of left colon and rectum: differences in clinical outcome and gene expression.Front Oncol202642063709PubTator, text miningPubMed
Interleukin 12β and EBI3: Emerging immunomodulatory members of the interleukin 12 family.Biochim Biophys Acta Mol Cell Res202641956257PubTator, text miningPubMed
Glucocorticoid signaling regulates expression of the EBI3 subunit of IL-27 in neonatal macrophages: Implications for antenatal corticosteroid therapy.bioRxiv202641929190PubTator, text miningPubMed

1 to 10 of 1,901

See all 1,901 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10148

GET https://conductscience.org/api/genes/v1/10148/patents?page=2