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Gene · 10155

TRIM28: tripartite motif containing 28

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRIM28: tripartite motif containing 28. Genes, record 10155. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10155

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Gene

Symbol
TRIM28
HGNC
Name
tripartite motif containing 28
HGNC
NCBI Gene ID
10155
NCBI Gene
HGNC ID
HGNC:16384
HGNC
Ensembl
ENSG00000130726
NCBI Gene
Aliases
KAP-1, KAP1, PPP1R157, RNF96, TF1B, TIF1-beta, TIF1B, TIF1beta, WT7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13263Transcription intermediary factor 1-beta83510Ensembl, GeneID, HGNC

Source UniProt

Patents85

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4828973 A22026-10-2846Q13263Espacenet
EP 4805378 A12026-09-16611Q13263Espacenet
JP 2026523341 A2026-07-141062Q13263Espacenet
EP 4771137 A12026-07-08629Q13263Espacenet
EP 4771157 A12026-07-08629Q13263Espacenet
US 12649003 B22026-06-091062Q13263Espacenet
JP 2026510339 A2026-04-02629Q13263Espacenet
EP 4713451 A22026-03-25629Q13263Espacenet
EP 4713452 A22026-03-25629Q13263Espacenet
US 12558437 B22026-02-241062Q13263Espacenet

1 to 10 of 85

See all 85 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,393

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRIM28 papersNewest fiscal year
P30CA016672Cancer Center Support Grant262025
P30CA008748Cancer Center Support Grant222025
P30CA010815Consolidated Basic Cancer Research Program182025
T32CA009171Training Program in Basic Cancer Research142025
ZIAHD008933Mammalian Development and Evolution132025
P30CA016086Cancer Center Support Grant102025
P30CA093373Cancer Center Support Grant P3082025
R35GM122550Genomic and Physiological Impact of Transposable Elements.72025
P30CA013696Cancer Center Support Grant62025
P30CA014520UW Comprehensive Cancer Center Support62025

1 to 10 of 2,393Source NIH's project files

See all 2,393 nih grants

Papers3,480

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Paeoniflorigenone triggers TRIM28 phosphorylation-dependent ferroptosis and immune activation to suppress intrahepatic cholangiocarcinoma.Pharmacol Res202642801968PubTator, text miningPubMed
TRIM28 contributes to epidermal homeostasis and is associated with altered p53 regulation.Front Cell Dev Biol202642775252PubTator, text miningPubMed
TRIM28 facilitates diffuse large B-cell lymphoma progression by inducing glycolytic reprogramming through the E2F1/PKM2 axis.Naunyn Schmiedebergs Arch Pharmacol202642760375PubTator, text miningPubMed
The TyrRS cascade: circadian gating of neuronal DNA repair and its collapse in aging.Geroscience202642749976PubTator, text miningPubMed
TRIM28 SUMOylates IRF3 in astrocytes to drive neutrophils infiltration and ischemic cerebral injury.Cell Death Differ202642745034PubTator, text miningPubMed
Cofilin/RhoA and CREB synergistically promote invasion and migration of polyploid giant cancer cells in colorectal cancer.J Cancer202642741318PubTator, text miningPubMed
TRIM28 Promotes Keratinocyte Proliferation and Invasion by Activating NLRP3/SGT1 Axis-Mediated Macrophage Pro-Inflammatory Polarization in an In Vitro Macrophage-Keratinocyte Co-Culture Model.Immun Inflamm Dis202642720284PubTator, text miningPubMed
Retinoic acid alleviates manganese-induced neurotoxicity in SH-SY5Y cells via the Trim28/α-synuclein/H4K91ac epigenetic axis.Front Pharmacol202642712674PubTator, text miningPubMed
Berberine, a natural molecular glue degrader, overcomes CML resistance via TRIM28-mediated HIF1α ubiquitination and subsequent ferroptosis.Cell Rep202642709544PubTator, text miningPubMed
PEDV envelope protein promotes viral replication by remodeling host iron homeostasis via the TRIM28-KLF15-FPN axis.J Virol202642684901PubTator, text miningPubMed

1 to 10 of 3,480

See all 3,480 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10155

GET https://conductscience.org/api/genes/v1/10155/patents?page=2