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Gene · 10159

ATP6AP2: ATPase H+ transporting accessory protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP6AP2: ATPase H+ transporting accessory protein 2. Genes, record 10159. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10159

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Gene

Symbol
ATP6AP2
HGNC
Name
ATPase H+ transporting accessory protein 2
HGNC
NCBI Gene ID
10159
NCBI Gene
HGNC ID
HGNC:18305
HGNC
Ensembl
ENSG00000182220
NCBI Gene
Aliases
(P)RR, APT6M8-9, ATP6IP2, ATP6M8-9, CDG2R, ELDF10, HT028, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75787Renin receptor35010Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438290O75787Espacenet
EP 4650780 A22025-11-1919125O75787Espacenet
EP 4641201 A22025-10-2924065O75787Espacenet
JP 2025147176 A2025-10-061251O75787Espacenet
JP 2025529142 A2025-09-04524O75787Espacenet
JP 2025529142 A2025-09-045548O75787Espacenet
US 12371689 B22025-07-29524O75787Espacenet
US 12371689 B22025-07-295548O75787Espacenet
JP 2025517969 A2025-06-1224065O75787Espacenet
JP 2025517970 A2025-06-1219125O75787Espacenet

1 to 10 of 53

See all 53 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,622

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP6AP2 papersNewest fiscal year
R01DK104072Cloning and characterization of PRR24 as a specific renin receptor critically involved in vasopressin signaling in the kidney222025
P30DK034854Integrated Epithelial and Muscosal Biology112025
P30CA008748Cancer Center Support Grant102025
P30DK034989Yale Liver Center102025
R01DK099097Functional outcomes of inflammatory bowel disease associated variants102025
U54GM104940Louisiana Clinical and Translational Science Center82025
R01DK067299Novel Roles and Mechanisms of Proximal Tubule Mitochondrial Angiotensin II and Sirtuin 3 in Hypertension72025
UL1TR001863Yale Clinical and Translational Science Award72025
R01AI137168Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis62025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations62025

1 to 10 of 1,622Source NIH's project files

See all 1,622 nih grants

Papers2,607

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mechanistic Assessment of Norepinephrine Therapy versus Angiotensin-II in Septic Shock (MANTRA): Study Protocol for a multicenter randomized trial.medRxiv202642779856PubTator, text miningPubMed
Pediatric Non-Neural Granular Cell Tumor With Unexpected Molecular Identity: A Case That Challenges Classification.Pediatr Dermatol202642680710PubTator, text miningPubMed
(Pro)renin Receptor Regulates LDL-C Metabolism and Exacerbates Atherosclerosis via SREBP2/PCSK9/LDLR Pathway.Korean Circ J202642669859PubTator, text miningPubMed
Indoxyl Sulfate and Soluble Prorenin Receptor Axis Contributes to Sarcopenia in Maintenance Hemodialysis Patients by Inducing Mitochondrial Damage: An Integrated Clinical and Experimental Study.J Ren Nutr202642628817PubTator, text miningPubMed
2024 Donald Seldin Lecture: New Insights Into Soluble (Pro)Renin Receptor in Hypertension and Kidney Disease.Hypertension202642605676PubTator, text miningPubMed
Association between adipose (pro)renin receptor expression and growth hormone deficiency in patients with non-functioning hypothalamic-pituitary masses.J Endocrinol Invest202642461577PubTator, text miningPubMed
Platelet RIP2 Limits Dense Granule Release and Thrombosis via DOCK8-Cdc42.Arterioscler Thromb Vasc Biol202642273729PubTator, text miningPubMed
Characterization of elevated levels of endometrial renin-angiotensin system components suggest a role in endometrial repair.Front Endocrinol (Lausanne)202642130729PubTator, text miningPubMed
Granular Cell Dermatofibroma Demonstrates Loss-of-Function Mutations in V-ATPase Component Genes.J Cutan Pathol202642108978PubTator, text miningPubMed
Spectrum and functions of ion channels and transporters in osteoclasts.Bone Res202641896521PubTator, text miningPubMed

1 to 10 of 2,607

See all 2,607 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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