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CDK2: cyclin dependent kinase 2

1 protein, 110 patents, 15 drugs, 107 trials, 9,818 NIH grants and 26,572 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCDK2HGNC
Namecyclin dependent kinase 2HGNC
NCBI Gene ID1017NCBI Gene
HGNC IDHGNC:1771HGNC
EnsemblENSG00000123374NCBI Gene
AliasesCDKN2, p33(CDK2)NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P24941Cyclin-dependent kinase 2298522Ensembl, GeneID, HGNCUniProt

Patents 110

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4679090 A12026-01-1424P24941Espacenet
EP 4650780 A22025-11-192593P24941Espacenet
JP 2025517970 A2025-06-122593P24941Espacenet
JP 2025032204 A2025-03-1126154P24941Espacenet
JP 2025013347 A2025-01-2429P24941Espacenet
US 12201675 B22025-01-2129P24941Espacenet
JP 2025003953 A2025-01-1429P24941Espacenet
KR 1020240162163 A2024-11-1429P24941Espacenet
EP 4461818 A22024-11-1326154P24941Espacenet
JP 2024123008 A2024-09-105781P24941Espacenet

Drugs 15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AG-24322CHEMBL3545420Cyclin-dependent kinase 2 inhibitorINHIBITORChEMBL
ALVOCIDIBCHEMBL428690Cyclin-dependent kinase 2 inhibitorINHIBITORChEMBL
AT-7519CHEMBL445813Cyclin-dependent kinase inhibitorINHIBITORChEMBL
AZD-5438CHEMBL488436Cyclin-dependent kinase inhibitorINHIBITORChEMBL
BMS-387032CHEMBL296468Cyclin-dependent kinase 2 inhibitorINHIBITORChEMBL
DINACICLIBCHEMBL2103840Cyclin-dependent kinase 2 inhibitorINHIBITORChEMBL
MILCICLIBCHEMBL564829Cyclin-dependent kinase 2 inhibitorINHIBITORChEMBL
PHA-793887CHEMBL1230607Cyclin-dependent kinase inhibitorINHIBITORChEMBL
RG-547CHEMBL384304Cyclin-dependent kinase 2 inhibitorINHIBITORChEMBL
RGB-286638CHEMBL3545083Cyclin-dependent kinase 2 inhibitorINHIBITORChEMBL

Trials 107

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05651269MILCICLIBPHASE2ClinicalTrials.gov
NCT04493099ALVOCIDIBPHASE1/PHASE2ClinicalTrials.gov
NCT03969420ALVOCIDIBPHASE22022-10-19ClinicalTrials.gov
NCT03904628ZOTIRACICLIBPHASE1ClinicalTrials.gov
NCT03774446SELICICLIBPHASE2ClinicalTrials.gov
NCT03738111ZOTIRACICLIBPHASE1ClinicalTrials.gov
NCT03593915ALVOCIDIBPHASE1/PHASE22022-10-21ClinicalTrials.gov
NCT03563560ALVOCIDIBPHASE1ClinicalTrials.gov
NCT03484520DINACICLIBPHASE1ClinicalTrials.gov
NCT03441555ALVOCIDIBPHASE1ClinicalTrials.gov

NIH grants 9818

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1832,025NIH's project files
P30CA008748Cancer Center Support Grant982,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)692,025NIH's project files
P30CA016058Cancer Center Support Grant332,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant332,025NIH's project files
P30CA068485Cancer Center Support Grant332,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant322,025NIH's project files
P30CA016086Cancer Center Support Grant312,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant302,025NIH's project files
P30CA006973Regional Oncology Research Center252,025NIH's project files

Papers 26572

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825474PubTator, text miningPubMed
42823736PubTator, text miningPubMed
42822413PubTator, text miningPubMed
42812068PubTator, text miningPubMed
42811332PubTator, text miningPubMed
42806616PubTator, text miningPubMed
42806296PubTator, text miningPubMed
42800300PubTator, text miningPubMed
42800165PubTator, text miningPubMed
42797334PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license