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Gene · 10188

TNK2: tyrosine kinase non receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TNK2: tyrosine kinase non receptor 2. Genes, record 10188. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10188

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Gene

Symbol
TNK2
HGNC
Name
tyrosine kinase non receptor 2
HGNC
NCBI Gene ID
10188
NCBI Gene
HGNC ID
HGNC:19297
HGNC
Ensembl
ENSG00000061938
NCBI Gene
Aliases
ACK, ACK-1, ACK1, p21cdc42Hs
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q07912Activated CDC42 kinase 11,03818Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468811Q07912Espacenet
JP 2026004568 A2026-01-1468813Q07912Espacenet
EP 4641201 A22025-10-295511Q07912Espacenet
JP 2025517969 A2025-06-125511Q07912Espacenet
JP 2025032204 A2025-03-1137401Q07912Espacenet
EP 4461818 A22024-11-1337401Q07912Espacenet
US 11884978 B22024-01-30777Q07912Espacenet
WO 2023090381 A2023-05-2591Q07912Espacenet
JP 2023058610 A2023-04-2537401Q07912Espacenet
US 11446398 B22022-09-2094307Q07912Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,349

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNK2 papersNewest fiscal year
P30CA076292Moffitt Cancer Center Support Grant232025
P30CA016672Cancer Center Support Grant132025
P30CA008748Cancer Center Support Grant92025
P30CA006927Comprehensive Cancer Center Program at Fox Chase82025
P30CA006973Regional Oncology Research Center62025
R01AI164424Nonreceptor tyrosine kinases in Systemic Lupus Erythematosus62025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant52025
R01CA273054Regulation of Mitochondrial Metabolism by Tyr-phosphorylated ATP Synthase Alpha-Subunit and its Therapeutic Implications in Prostate Cancer52025
R35GM119437Dynamics of Ligand Binding and Protein Kinase Regulation52025
P30CA016056Roswell Park Cancer Center Support Grant42025

1 to 10 of 1,349Source NIH's project files

See all 1,349 nih grants

Papers1,711

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Repeated intravenous thrombolysis for ischaemic stroke with medium to large vessel occlusion presenting within 4.5 hours of onset with tenecteplase in China (RITIS-TNK2): protocol for a prospective, randomised, open-label, blinded assessment of outcome and multicentre study.
BMJ Open202642629154PubTator, text miningPubMed
Potential small-molecule tyrosine kinase inhibitors (TKIs) for the treatment of triple-negative breast cancer (TNBC): Targets, structure-activity relationships, and clinical studies.Eur J Med Chem202642612290PubTator, text miningPubMed
Beyond acetylation: Evaluating the emerging biology of lysine acylation.Cell Chem Biol202642586062PubTator, text miningPubMed
Process-resolved effects of dibutyl phthalate on sludge anaerobic fermentation: Enzyme inhibition and metabolic disruption underlie the suppression of acidogenesis.J Hazard Mater202642585962PubTator, text miningPubMed
ACK family tyrosine kinases as potential therapeutic targets for cancer.Expert Opin Ther Targets202642504143PubTator, text miningPubMed
A Novel BRAF-TNK2 Fusion in a Teenage Girl With Pilocytic Astrocytoma.Pediatr Blood Cancer202642500922PubTator, text miningPubMed
Genetic heterogeneity, movement disorders, and white matter abnormalities in pediatric developmental and epileptic encephalopathies: A retrospective cohort study from a National Neurodegenerative and Leukodystrophy Registry.
Epilepsy Res202642407302PubTator, text miningPubMed
Quinoline-2-carboxamide-phenylacetamide hybrids as preliminary antimicrobial and cytotoxic hits: Synthesis, biological screening, molecular docking, and in silico ADMET profiling.J Comput Aided Mol Des202642249128PubTator, text miningPubMed
Screening of molecular signatures from microRNA and mRNA expression profiling related to the efficacy of the antidepressant duloxetine and analysis of their regulatory relationship.Biomed Pharmacother202641997083PubTator, text miningPubMed
Development and Launch of a Dutch Mobile App (MediMama) on Over-the-Counter Medication Safety During Pregnancy and Breastfeeding: Development and Usability Study.JMIR Mhealth Uhealth202641926731PubTator, text miningPubMed

1 to 10 of 1,711

See all 1,711 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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