Gene · 10188
TNK2: tyrosine kinase non receptor 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TNK2: tyrosine kinase non receptor 2. Genes, record 10188. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10188
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q07912 | Activated CDC42 kinase 1 | 1,038 | 18 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68811 | Q07912 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 68813 | Q07912 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5511 | Q07912 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5511 | Q07912 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 37401 | Q07912 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 37401 | Q07912 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 777 | Q07912 | Espacenet |
| WO 2023090381 A | 2023-05-25 | 91 | Q07912 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 37401 | Q07912 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 94307 | Q07912 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,349
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TNK2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA076292 | Moffitt Cancer Center Support Grant | 23 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 8 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 6 | 2025 |
| R01AI164424 | Nonreceptor tyrosine kinases in Systemic Lupus Erythematosus | 6 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 5 | 2025 |
| R01CA273054 | Regulation of Mitochondrial Metabolism by Tyr-phosphorylated ATP Synthase Alpha-Subunit and its Therapeutic Implications in Prostate Cancer | 5 | 2025 |
| R35GM119437 | Dynamics of Ligand Binding and Protein Kinase Regulation | 5 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,349Source NIH's project files
See all 1,349 nih grantsPapers1,711
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Repeated intravenous thrombolysis for ischaemic stroke with medium to large vessel occlusion presenting within 4.5 hours of onset with tenecteplase in China (RITIS-TNK2): protocol for a prospective, randomised, open-label, blinded assessment of outcome and multicentre study. | BMJ Open | 2026 | 42629154 | PubTator, text mining | PubMed |
| Potential small-molecule tyrosine kinase inhibitors (TKIs) for the treatment of triple-negative breast cancer (TNBC): Targets, structure-activity relationships, and clinical studies. | Eur J Med Chem | 2026 | 42612290 | PubTator, text mining | PubMed |
| Beyond acetylation: Evaluating the emerging biology of lysine acylation. | Cell Chem Biol | 2026 | 42586062 | PubTator, text mining | PubMed |
| Process-resolved effects of dibutyl phthalate on sludge anaerobic fermentation: Enzyme inhibition and metabolic disruption underlie the suppression of acidogenesis. | J Hazard Mater | 2026 | 42585962 | PubTator, text mining | PubMed |
| ACK family tyrosine kinases as potential therapeutic targets for cancer. | Expert Opin Ther Targets | 2026 | 42504143 | PubTator, text mining | PubMed |
| A Novel BRAF-TNK2 Fusion in a Teenage Girl With Pilocytic Astrocytoma. | Pediatr Blood Cancer | 2026 | 42500922 | PubTator, text mining | PubMed |
Genetic heterogeneity, movement disorders, and white matter abnormalities in pediatric developmental and epileptic encephalopathies: A retrospective cohort study from a National Neurodegenerative and Leukodystrophy Registry. | Epilepsy Res | 2026 | 42407302 | PubTator, text mining | PubMed |
| Quinoline-2-carboxamide-phenylacetamide hybrids as preliminary antimicrobial and cytotoxic hits: Synthesis, biological screening, molecular docking, and in silico ADMET profiling. | J Comput Aided Mol Des | 2026 | 42249128 | PubTator, text mining | PubMed |
| Screening of molecular signatures from microRNA and mRNA expression profiling related to the efficacy of the antidepressant duloxetine and analysis of their regulatory relationship. | Biomed Pharmacother | 2026 | 41997083 | PubTator, text mining | PubMed |
| Development and Launch of a Dutch Mobile App (MediMama) on Over-the-Counter Medication Safety During Pregnancy and Breastfeeding: Development and Usability Study. | JMIR Mhealth Uhealth | 2026 | 41926731 | PubTator, text mining | PubMed |
1 to 10 of 1,711
See all 1,711 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10188
GET https://conductscience.org/api/genes/v1/10188/patents?page=2