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Gene · 10189

ALYREF: Aly/REF export factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ALYREF: Aly/REF export factor. Genes, record 10189. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10189

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Gene

Symbol
ALYREF
HGNC
Name
Aly/REF export factor
HGNC
NCBI Gene ID
10189
NCBI Gene
HGNC ID
HGNC:19071
HGNC
Ensembl
ENSG00000183684
NCBI Gene
Aliases
ALY, ALY/REF, BEF, REF, THOC4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q86V81THO complex subunit 42574GeneID, HGNC

Source UniProt

Patents11

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1944607Q86V81Espacenet
JP 2025517970 A2025-06-1244607Q86V81Espacenet
US 11564998 B22023-01-315545Q86V81Espacenet
KR 1020200067627 A2020-06-127Q86V81Espacenet
WO 2020043864 A12020-03-052596Q86V81Espacenet
US 10463751 B22019-11-055545Q86V81Espacenet
JP 2018023373 A2018-02-1528272Q86V81Espacenet
US 9572897 B22017-02-215545Q86V81Espacenet
US 9303079 B22016-04-055545Q86V81Espacenet
JP 2015519040 A2015-07-0928272Q86V81Espacenet

1 to 10 of 11

See all 11 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants953

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleALYREF papersNewest fiscal year
ZIASC010357Gene Expression and Post-Transcriptional Regulation of DNA Tumor Viruses82025
R01AI125524Kinase Regulation of Nuclear Speckle Function and Splicing during Influenza Virus Infection72025
P30CA008748Cancer Center Support Grant62025
R35GM133743Mechanisms and Regulation of Nuclear mRNA Export62025
R01CA080728Oncogenic Impact of eIF4E-dependent RNA Export in Cancer52025
R01CA098571Molecular Mechanisms of eIF4E Mediated Transformation42025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions32025
P30CA015704Cancer Center Support Grant32025
P30CA016058Cancer Center Support Grant32025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center32025

1 to 10 of 953Source NIH's project files

See all 953 nih grants

Papers1,565

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6-Mediated Wnt/β-catenin Signaling Pathway.Adv Sci (Weinh)202642801705PubTator, text miningPubMed
Variants in TREX complex subunits (THOC2, ALYREF, THOC6, THOC7) define a neurodevelopmental disability spectrum.Genet Med202642781784PubTator, text miningPubMed
ALYREF-mediated m5C modification of CCNA1 drives escape from cell-cycle arrest and contributes to pazopanib resistance in Renal Cell Carcinoma.Int J Biol Sci202642524522PubTator, text miningPubMed
Exon junction complex and nuclear pore complex components preferentially govern the nuclear export of spliced lncRNAs.Cell Death Discov202642420243PubTator, text miningPubMed
Tumor-Associated Neutrophils Secrete AGR2 to Promote Colorectal Cancer Progression by Stabilizing ALYREF to Boost Snail m5C Modification.FASEB J202642241033PubTator, text miningPubMed
Molecular Mechanism of NSUN6-Mediated Epigenetic Modifications in the Malignant Progression of Colorectal Cancer Cells.FASEB J202642165352PubTator, text miningPubMed
Probing RNA-protein interactions in the early mouse embryo.bioRxiv202642146647PubTator, text miningPubMed
NSUN2/ALYREF stabilizes m5C-modified circCEP70 to enhance radioresistance in rectal cancer through NEDD8-dependent neddylation and ubiquitination regulation.Int J Biol Macromol202642106046PubTator, text miningPubMed
RNA methylation in cardiovascular remodeling: Molecular mechanisms, biomarkers, and therapeutic strategies.Mol Biol Rep202642084676PubTator, text miningPubMed
Aly as a Key Regulator of DNA Repair and Immune Evasion in Esophageal Squamous Cell Carcinoma Radioresistance.Int J Radiat Oncol Biol Phys202642034193PubTator, text miningPubMed

1 to 10 of 1,565

See all 1,565 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10189

GET https://conductscience.org/api/genes/v1/10189/patents