Gene · 10189
ALYREF: Aly/REF export factor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ALYREF: Aly/REF export factor. Genes, record 10189. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10189
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q86V81 | THO complex subunit 4 | 257 | 4 | GeneID, HGNC |
Source UniProt
Patents11
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 44607 | Q86V81 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 44607 | Q86V81 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5545 | Q86V81 | Espacenet |
| KR 1020200067627 A | 2020-06-12 | 7 | Q86V81 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 2596 | Q86V81 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 5545 | Q86V81 | Espacenet |
| JP 2018023373 A | 2018-02-15 | 28272 | Q86V81 | Espacenet |
| US 9572897 B2 | 2017-02-21 | 5545 | Q86V81 | Espacenet |
| US 9303079 B2 | 2016-04-05 | 5545 | Q86V81 | Espacenet |
| JP 2015519040 A | 2015-07-09 | 28272 | Q86V81 | Espacenet |
1 to 10 of 11
See all 11 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants953
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ALYREF papers | Newest fiscal year |
|---|---|---|---|
| ZIASC010357 | Gene Expression and Post-Transcriptional Regulation of DNA Tumor Viruses | 8 | 2025 |
| R01AI125524 | Kinase Regulation of Nuclear Speckle Function and Splicing during Influenza Virus Infection | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| R35GM133743 | Mechanisms and Regulation of Nuclear mRNA Export | 6 | 2025 |
| R01CA080728 | Oncogenic Impact of eIF4E-dependent RNA Export in Cancer | 5 | 2025 |
| R01CA098571 | Molecular Mechanisms of eIF4E Mediated Transformation | 4 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 3 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 3 | 2025 |
| P30CA142543 | UT Southwestern Medical Center Simmons Comprehensive Cancer Center | 3 | 2025 |
1 to 10 of 953Source NIH's project files
See all 953 nih grantsPapers1,565
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6-Mediated Wnt/β-catenin Signaling Pathway. | Adv Sci (Weinh) | 2026 | 42801705 | PubTator, text mining | PubMed |
| Variants in TREX complex subunits (THOC2, ALYREF, THOC6, THOC7) define a neurodevelopmental disability spectrum. | Genet Med | 2026 | 42781784 | PubTator, text mining | PubMed |
| ALYREF-mediated m5C modification of CCNA1 drives escape from cell-cycle arrest and contributes to pazopanib resistance in Renal Cell Carcinoma. | Int J Biol Sci | 2026 | 42524522 | PubTator, text mining | PubMed |
| Exon junction complex and nuclear pore complex components preferentially govern the nuclear export of spliced lncRNAs. | Cell Death Discov | 2026 | 42420243 | PubTator, text mining | PubMed |
| Tumor-Associated Neutrophils Secrete AGR2 to Promote Colorectal Cancer Progression by Stabilizing ALYREF to Boost Snail m5C Modification. | FASEB J | 2026 | 42241033 | PubTator, text mining | PubMed |
| Molecular Mechanism of NSUN6-Mediated Epigenetic Modifications in the Malignant Progression of Colorectal Cancer Cells. | FASEB J | 2026 | 42165352 | PubTator, text mining | PubMed |
| Probing RNA-protein interactions in the early mouse embryo. | bioRxiv | 2026 | 42146647 | PubTator, text mining | PubMed |
| NSUN2/ALYREF stabilizes m5C-modified circCEP70 to enhance radioresistance in rectal cancer through NEDD8-dependent neddylation and ubiquitination regulation. | Int J Biol Macromol | 2026 | 42106046 | PubTator, text mining | PubMed |
| RNA methylation in cardiovascular remodeling: Molecular mechanisms, biomarkers, and therapeutic strategies. | Mol Biol Rep | 2026 | 42084676 | PubTator, text mining | PubMed |
| Aly as a Key Regulator of DNA Repair and Immune Evasion in Esophageal Squamous Cell Carcinoma Radioresistance. | Int J Radiat Oncol Biol Phys | 2026 | 42034193 | PubTator, text mining | PubMed |
1 to 10 of 1,565
See all 1,565 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10189
GET https://conductscience.org/api/genes/v1/10189/patents