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CDK4: cyclin dependent kinase 4

1 protein, 161 patents, 18 drugs, 784 trials, 9,531 NIH grants and 29,697 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCDK4HGNC
Namecyclin dependent kinase 4HGNC
NCBI Gene ID1019NCBI Gene
HGNC IDHGNC:1773HGNC
EnsemblENSG00000135446NCBI Gene
AliasesCMM3, MCPH31, PSK-J3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P11802Cyclin-dependent kinase 430315Ensembl, GeneID, HGNCUniProt

Patents 161

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12661384 B22026-06-2314P11802Espacenet
JP 2026511570 A2026-04-1434P11802Espacenet
EP 4670728 A12025-12-3134P11802Espacenet
KR 1020250166953 A2025-11-2834P11802Espacenet
EP 4650780 A22025-11-191656P11802Espacenet
EP 4641201 A22025-10-291262P11802Espacenet
EP 4641202 A22025-10-294489P11802Espacenet
JP 2025517969 A2025-06-121262P11802Espacenet
JP 2025517970 A2025-06-121656P11802Espacenet
US 12264339 B22025-04-0137P11802Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEMACICLIBCHEMBL3301610Cyclin-dependent kinase 4 inhibitorINHIBITORChEMBL
AG-24322CHEMBL3545420Cyclin-dependent kinase 4 inhibitorINHIBITORChEMBL
ALVOCIDIBCHEMBL428690Cyclin-dependent kinase 4 inhibitorINHIBITORChEMBL
AT-7519CHEMBL445813Cyclin-dependent kinase inhibitorINHIBITORChEMBL
AZD-5438CHEMBL488436Cyclin-dependent kinase inhibitorINHIBITORChEMBL
MILCICLIBCHEMBL564829Cyclin-dependent kinase 4 inhibitorINHIBITORChEMBL
PALBOCICLIBCHEMBL189963Cyclin-dependent kinase 4/cyclin D1 inhibitorINHIBITORChEMBL
PHA-793887CHEMBL1230607Cyclin-dependent kinase inhibitorINHIBITORChEMBL
RG-547CHEMBL384304Cyclin-dependent kinase 4 inhibitorINHIBITORChEMBL
RGB-286638CHEMBL3545083Cyclin-dependent kinase 4 inhibitorINHIBITORChEMBL

Trials 784

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07599137ABEMACICLIBPHASE4ClinicalTrials.gov
NCT07543250PALBOCICLIBClinicalTrials.gov
NCT07493291PALBOCICLIBClinicalTrials.gov
NCT07473128TRILACICLIBPHASE3ClinicalTrials.gov
NCT07441369ABEMACICLIBPHASE2ClinicalTrials.gov
NCT07428018ABEMACICLIBPHASE2ClinicalTrials.gov
NCT07423611RIBOCICLIBPHASE2ClinicalTrials.gov
NCT07410559ABEMACICLIBPHASE2ClinicalTrials.gov
NCT07405801RIBOCICLIBPHASE2ClinicalTrials.gov
NCT07400523RIBOCICLIBPHASE3ClinicalTrials.gov

NIH grants 9531

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2932,025NIH's project files
P30CA008748Cancer Center Support Grant2872,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)702,025NIH's project files
P30CA016058Cancer Center Support Grant472,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant432,025NIH's project files
P30CA006973Regional Oncology Research Center382,025NIH's project files
P30CA068485Cancer Center Support Grant372,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant362,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program332,025NIH's project files
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center332,025NIH's project files

Papers 29697

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823736PubTator, text miningPubMed
42821040PubTator, text miningPubMed
42817679PubTator, text miningPubMed
42815008PubTator, text miningPubMed
42814245PubTator, text miningPubMed
42812792PubTator, text miningPubMed
42811741PubTator, text miningPubMed
42802426PubTator, text miningPubMed
42794337PubTator, text miningPubMed
42790158PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license