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CDK5: cyclin dependent kinase 5

1 protein, 81 patents, 7 drugs, 31 trials, 4,525 NIH grants and 7,859 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCDK5HGNC
Namecyclin dependent kinase 5HGNC
NCBI Gene ID1020NCBI Gene
HGNC IDHGNC:1774HGNC
EnsemblENSG00000164885NCBI Gene
AliasesLIS7, PSSALRENCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q00535Cyclin-dependent kinase 529210Ensembl, GeneID, HGNCUniProt

Patents 81

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442665Q00535Espacenet
EP 4650780 A22025-11-1914368Q00535Espacenet
JP 2025517970 A2025-06-1214368Q00535Espacenet
JP 2025013347 A2025-01-2432Q00535Espacenet
US 12201675 B22025-01-2132Q00535Espacenet
JP 2025003953 A2025-01-1432Q00535Espacenet
KR 1020240162163 A2024-11-1432Q00535Espacenet
EP 4406585 A22024-07-3132Q00535Espacenet
US 12006508 B22024-06-1132Q00535Espacenet
JP 2024056815 A2024-04-2332Q00535Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AT-7519CHEMBL445813Cyclin-dependent kinase inhibitorINHIBITORChEMBL
AZD-5438CHEMBL488436Cyclin-dependent kinase inhibitorINHIBITORChEMBL
DINACICLIBCHEMBL2103840Cyclin-dependent kinase 5 inhibitorINHIBITORChEMBL
PHA-793887CHEMBL1230607Cyclin-dependent kinase inhibitorINHIBITORChEMBL
RGB-286638CHEMBL3545083Cyclin-dependent kinase 5 inhibitorINHIBITORChEMBL
RONICICLIBCHEMBL4442620Cyclin-dependent kinase inhibitorINHIBITORChEMBL
SELICICLIBCHEMBL14762Cyclin-dependent kinase 5 inhibitorINHIBITORChEMBL

Trials 31

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03774446SELICICLIBPHASE2ClinicalTrials.gov
NCT03484520DINACICLIBPHASE1ClinicalTrials.gov
NCT02684617DINACICLIBPHASE12021-03-01ClinicalTrials.gov
NCT02649751SELICICLIBPHASE2ClinicalTrials.gov
NCT02522910RONICICLIBPHASE1/PHASE2ClinicalTrials.gov
NCT02161419RONICICLIBPHASE2ClinicalTrials.gov
NCT01783171DINACICLIBPHASE1ClinicalTrials.gov
NCT01711528DINACICLIBPHASE1ClinicalTrials.gov
NCT01676753DINACICLIBPHASE1ClinicalTrials.gov
NCT01652144AT-7519PHASE2ClinicalTrials.gov

NIH grants 4525

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIADE000664Characterization of Molecular Pathways in Chronic Pain Conditions392,025NIH's project files
P30CA016672Cancer Center Support Grant242,025NIH's project files
P30CA008748Cancer Center Support Grant152,025NIH's project files
P30DA018343Yale/NIDA Neuroproteomics Center152,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)112,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant102,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant102,025NIH's project files
P30MH062512HIV Neurobehavioral Research Center102,025NIH's project files
R01DA007359Molecular Studies of Cocaine Action in Brain102,025NIH's project files
P30CA030199Cancer Center Support Grant (CCSG)92,025NIH's project files

Papers 7859

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42790732PubTator, text miningPubMed
42750155PubTator, text miningPubMed
42744729PubTator, text miningPubMed
42738249PubTator, text miningPubMed
42691238PubTator, text miningPubMed
42650106PubTator, text miningPubMed
42594421PubTator, text miningPubMed
42582898PubTator, text miningPubMed
42563243PubTator, text miningPubMed
42502315PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license