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Gene · 10203

CALCRL: calcitonin receptor like receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CALCRL: calcitonin receptor like receptor. Genes, record 10203. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10203

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Gene

Symbol
CALCRL
HGNC
Name
calcitonin receptor like receptor
HGNC
NCBI Gene ID
10203
NCBI Gene
HGNC ID
HGNC:16709
HGNC
Ensembl
ENSG00000064989
NCBI Gene
Aliases
CGRPR, CRLR, LMPHM8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16602Calcitonin gene-related peptide type 1 receptor46125Ensembl, GeneID, HGNC

Source UniProt

Patents86

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025259600 A22025-12-1815Q16602Espacenet
EP 4650780 A22025-11-1910914Q16602Espacenet
JP 2025147176 A2025-10-062003Q16602Espacenet
JP 2025147176 A2025-10-062004Q16602Espacenet
JP 2025147176 A2025-10-062005Q16602Espacenet
JP 2025517970 A2025-06-1210914Q16602Espacenet
EP 4541896 A12025-04-23271Q16602Espacenet
JP 2025062604 A2025-04-1410508Q16602Espacenet
JP 2025062604 A2025-04-1410510Q16602Espacenet
JP 2025062604 A2025-04-1410511Q16602Espacenet

1 to 10 of 86

See all 86 patents

Drugs13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATOGEPANTCHEMBL3991065Calcitonin gene-related peptide type 1 receptor antagonistANTAGONISTChEMBL
BI-44370CHEMBL3334624Calcitonin gene-related peptide type 1 receptor antagonistANTAGONISTChEMBL
DAVALINTIDECHEMBL2105635Calcitonin gene-related peptide type 1 receptor agonistAGONISTChEMBL
ERENUMABCHEMBL3833329Calcitonin gene-related peptide type 1 receptor antagonistANTAGONISTChEMBL
MK3207CHEMBL1910936Calcitonin gene-related peptide type 1 receptor antagonistANTAGONISTChEMBL
OLCEGEPANTCHEMBL207197Calcitonin gene-related peptide type 1 receptor antagonistANTAGONISTChEMBL
RIMEGEPANTCHEMBL2178422Calcitonin gene-related peptide type 1 receptor antagonistANTAGONISTChEMBL
RIMEGEPANT SULFATECHEMBL2364629Calcitonin gene-related peptide type 1 receptor antagonistANTAGONISTChEMBL
TELCAGEPANTCHEMBL236593Calcitonin gene-related peptide type 1 receptor antagonistANTAGONISTChEMBL
UBROGEPANTCHEMBL2364638Calcitonin gene-related peptide type 1 receptor antagonistANTAGONISTChEMBL

1 to 10 of 13

See all 13 drugs

Trials125

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants836

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCALCRL papersNewest fiscal year
R01HD060860Adrenomedullin Signaling at the Maternal-Fetal Interface112025
R01NS102722Endosomal Platforms for Signaling Pain42025
T32GM136640Tri-institutional PhD Program in Chemical Biology42025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis32025
T32HL069768Pre-doctoral Training Program in Integrative Vascular Biology32025
UL1TR001863Yale Clinical and Translational Science Award32025
P01AG051459Competing Renewal P0122025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA016672Cancer Center Support Grant22025

1 to 10 of 836Source NIH's project files

See all 836 nih grants

Papers1,370

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Calcitonin gene-related peptide promotes mast cell-mediated neuroimmune inflammation through the CALCRL/RAMP1-JAK3-STAT1 axis in rosacea.Front Immunol202642751103PubTator, text miningPubMed
The RAMP3 proximity interactor MYO6 determines spatiotemporal signaling of the GPCR CLR in lymphatic endothelial cells.Sci Signal202642743267PubTator, text miningPubMed
Druggable tumor-nerve-immune circuits in cancer pain: Model systems, human translatability and therapeutic paradoxes.Pharmacol Res202642716238PubTator, text miningPubMed
Metabolic and Candidate Genetic Factors Associated with Overweight/Obesity in Patients of Kazakh Ethnicity with Psoriasis: A Cross-Sectional Study.Medicina (Kaunas)202642654346PubTator, text miningPubMed
Integrated Gene-Metabolite Network Analysis Identifies Pathways Associated with Immune Regulation and Metabolic Remodeling in Subfertile Beef Heifers.Genes (Basel)202642650082PubTator, text miningPubMed
Multi-omics analyses reveal new insights into the genetic mechanisms of external genitalia erectile dysfunction in male geese.Poult Sci202642526090PubTator, text miningPubMed
Novel Role for CGRP in Aqueous Humor Outflow.Invest Ophthalmol Vis Sci202642461077PubTator, text miningPubMed
Chronic migraine management with onabotulinumtoxinA and anti-CGRP/R monoclonal antibodies in an Italian real-world setting: update on therapeutic appropriateness and an emerging role of pharmacy.Front Pharmacol202642460013PubTator, text miningPubMed
Long-term treatment with Eptinezumab in special treatment situations: Real world data.J Neurol Sci202642442067PubTator, text miningPubMed
Machine learning-based integration develops a novel lysosome-related prognostic signature associated with prognosis and immune infiltration landscape in acute myeloid leukemia.Discov Oncol202642334654PubTator, text miningPubMed

1 to 10 of 1,370

See all 1,370 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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