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Gene · 10216

PRG4: proteoglycan 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRG4: proteoglycan 4. Genes, record 10216. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10216

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Gene

Symbol
PRG4
HGNC
Name
proteoglycan 4
HGNC
NCBI Gene ID
10216
NCBI Gene
HGNC ID
HGNC:9364
HGNC
Ensembl
ENSG00000116690
NCBI Gene
Aliases
CACP, FLJ32635, HAPO, JCAP, MSF, SZP, bG174L6.2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92954Proteoglycan 41,4040Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1912990Q92954Espacenet
EP 4641201 A22025-10-2914589Q92954Espacenet
JP 2025147176 A2025-10-0610764Q92954Espacenet
JP 2025529142 A2025-09-047428Q92954Espacenet
US 12371689 B22025-07-297428Q92954Espacenet
JP 2025517969 A2025-06-1214589Q92954Espacenet
JP 2025517970 A2025-06-1212990Q92954Espacenet
EP 4549941 A12025-05-075Q92954Espacenet
JP 2025028160 A2025-02-2810764Q92954Espacenet
JP 2025019058 A2025-02-0611Q92954Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,053

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRG4 papersNewest fiscal year
R01AR063759Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state52025
T32HG002295Training in Bioinformatics and Integrative Genomics52025
P30AR069619Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)32025
P30CA008748Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
P30EY026877Stanford Vision Research Core32025
R01AG044034Oxidative Stress and the Development of Osteoarthritis32025
R01AR070736Uncovering the role of Setbp1 in fibroblast-like synoviocytes during inflammatory arthritis32025
T32AR007530Immunologic Mechanisms and Rheumatic Diseases32025

1 to 10 of 1,053Source NIH's project files

See all 1,053 nih grants

Papers2,024

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Disease-first public-data integration with local virtual knockout prioritizes shared proteins linking osteoarthritis and osteoporosis.PLoS One202642821566PubTator, text miningPubMed
Lubricin (PRG4) in articular cartilage and intervertebral disc: Comparative biology and therapeutic potential.Osteoarthritis Cartilage202642790727PubTator, text miningPubMed
Cellularized Thermoformed Scaffolds with Human Septal Chondrocytes Support In Vivo Cartilage Maturation for Auricular Reconstruction.J Funct Biomater202642783699PubTator, text miningPubMed
The influence of walking speed on the mechanoresponsiveness of biomarkers.Connect Tissue Res202642732455PubTator, text miningPubMed
Normal human synovial fluid exhibits stable hyaluronic acid and proteoglycan 4 levels across age and sex.Osteoarthr Cartil Open202642729729PubTator, text miningPubMed
Systemic and local autoantibody responses to extracellular matrix proteins define inflammatory phenotypes across arthropathies.Rheumatology (Oxford)202642714959PubTator, text miningPubMed
Diagnostic Utility of Extracellular Levels of Serum Amyloid P and Proteoglycan 4: A Case-Control Study in Gestational Diabetes Mellitus.Int J Gen Med202642668852PubTator, text miningPubMed
Single-cell RNA sequencing reveals chondrocyte heterogeneity and fibrocartilage transition in osteonecrosis of the femoral head.iScience202642668562PubTator, text miningPubMed
Integrated Analysis of Multiple Databases Identifies Tissue Inhibitor of Metalloproteinase 1 Expression and Its Association with the Immune Microenvironment in Colorectal Cancer.Genes (Basel)202642650169PubTator, text miningPubMed
Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome masquerading as juvenile idiopathic arthritis: a case series with a novel PRG4 variant and emphasis on bone health.Pediatr Rheumatol Online J202642482035PubTator, text miningPubMed

1 to 10 of 2,024

See all 2,024 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10216

GET https://conductscience.org/api/genes/v1/10216/patents?page=2