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Gene · 10220

GDF11: growth differentiation factor 11

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GDF11: growth differentiation factor 11. Genes, record 10220. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10220

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Gene

Symbol
GDF11
HGNC
Name
growth differentiation factor 11
HGNC
NCBI Gene ID
10220
NCBI Gene
HGNC ID
HGNC:4216
HGNC
Ensembl
ENSG00000135414
NCBI Gene
Aliases
BMP-11, BMP11, VHO
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95390Growth/differentiation factor 114075Ensembl, GeneID, HGNC

Source UniProt

Patents193

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026138951 A2026-08-313O95390Espacenet
EP 4755449 A22026-06-1081O95390Espacenet
EP 4755450 A22026-06-1081O95390Espacenet
JP 2026004568 A2026-01-1448314O95390Espacenet
JP 2026001164 A2026-01-0681O95390Espacenet
JP 2026500221 A2026-01-0646O95390Espacenet
EP 4650780 A22025-11-191653O95390Espacenet
JP 2025169385 A2025-11-1281O95390Espacenet
JP 2025147176 A2025-10-065847O95390Espacenet
JP 2025529142 A2025-09-046472O95390Espacenet

1 to 10 of 193

See all 193 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants897

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGDF11 papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant52025
R01DK095112Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism42025
P30CA016672Cancer Center Support Grant32025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)32025
T32DK007260Training Grant in Diabetes and Metabolism32025
P01CA108671Myeloproliferative Neoplasms-Research Consortium22025
P30AG028740University of Florida Older Americans Independence Center (OAIC)22025
P30AG050886Comparative Bioenergetics of Aging22025
P30CA023168Cancer Center Support Grant22025

1 to 10 of 897Source NIH's project files

See all 897 nih grants

Papers1,347

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Follistatin drives AR-independent prostate cancer through BMP signaling inactivation and microenvironmental remodeling.Proc Natl Acad Sci U S A202642784510PubTator, text miningPubMed
PCBP2 facilitates miR-93-5p-mediated repression of GDF11 in HCC cell lines.Mol Ther Nucleic Acids202642732236PubTator, text miningPubMed
Serum BAFF and GDF11: cross-sectional associations with glycolipid metabolism and subclinical carotid artery wall thickening in elderly type 2 diabetes patients.Front Cardiovasc Med202642682957PubTator, text miningPubMed
The crystal structure of the activin B:Fst288 complex and computational insights into the broad antagonistic activity and specificity of follistatin.J Biol Chem202642607890PubTator, text miningPubMed
Association of serum growth differentiation factor 11 with asthma severity, inflammation, and airway remodeling in pediatric patients.Front Med (Lausanne)202642548683PubTator, text miningPubMed
Preclinical development of an extended half-life anti-myostatin monoclonal antibody.Sci Rep202642380199PubTator, text miningPubMed
Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential.Arch Pharm Res202642315824PubTator, text miningPubMed
Growth differentiation factor-11 inhibits the progression of acute myeloid leukemia and increases chemosensitivity by inhibiting cathepsin S.Anticancer Drugs202642307925PubTator, text miningPubMed
Growth differentiation factor 11 (GDF11) signaling in neural stem cell regulation: molecular and cellular insights.Rev Neurosci202642299745PubTator, text miningPubMed
A Multimodal Framework for Alzheimer's Prevention: Diet, Exercise, Fasting, Sleep, and Gut Microbiota.Curr Alzheimer Res202642099162PubTator, text miningPubMed

1 to 10 of 1,347

See all 1,347 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10220

GET https://conductscience.org/api/genes/v1/10220/patents?page=2