Gene · 10220
GDF11: growth differentiation factor 11
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GDF11: growth differentiation factor 11. Genes, record 10220. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10220
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95390 | Growth/differentiation factor 11 | 407 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents193
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026138951 A | 2026-08-31 | 3 | O95390 | Espacenet |
| EP 4755449 A2 | 2026-06-10 | 81 | O95390 | Espacenet |
| EP 4755450 A2 | 2026-06-10 | 81 | O95390 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 48314 | O95390 | Espacenet |
| JP 2026001164 A | 2026-01-06 | 81 | O95390 | Espacenet |
| JP 2026500221 A | 2026-01-06 | 46 | O95390 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1653 | O95390 | Espacenet |
| JP 2025169385 A | 2025-11-12 | 81 | O95390 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5847 | O95390 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6472 | O95390 | Espacenet |
1 to 10 of 193
See all 193 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants897
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GDF11 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA082709 | Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant | 5 | 2025 |
| R01DK095112 | Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 3 | 2025 |
| T32DK007260 | Training Grant in Diabetes and Metabolism | 3 | 2025 |
| P01CA108671 | Myeloproliferative Neoplasms-Research Consortium | 2 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 2 | 2025 |
| P30AG050886 | Comparative Bioenergetics of Aging | 2 | 2025 |
| P30CA023168 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 897Source NIH's project files
See all 897 nih grantsPapers1,347
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Follistatin drives AR-independent prostate cancer through BMP signaling inactivation and microenvironmental remodeling. | Proc Natl Acad Sci U S A | 2026 | 42784510 | PubTator, text mining | PubMed |
| PCBP2 facilitates miR-93-5p-mediated repression of GDF11 in HCC cell lines. | Mol Ther Nucleic Acids | 2026 | 42732236 | PubTator, text mining | PubMed |
| Serum BAFF and GDF11: cross-sectional associations with glycolipid metabolism and subclinical carotid artery wall thickening in elderly type 2 diabetes patients. | Front Cardiovasc Med | 2026 | 42682957 | PubTator, text mining | PubMed |
| The crystal structure of the activin B:Fst288 complex and computational insights into the broad antagonistic activity and specificity of follistatin. | J Biol Chem | 2026 | 42607890 | PubTator, text mining | PubMed |
| Association of serum growth differentiation factor 11 with asthma severity, inflammation, and airway remodeling in pediatric patients. | Front Med (Lausanne) | 2026 | 42548683 | PubTator, text mining | PubMed |
| Preclinical development of an extended half-life anti-myostatin monoclonal antibody. | Sci Rep | 2026 | 42380199 | PubTator, text mining | PubMed |
| Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential. | Arch Pharm Res | 2026 | 42315824 | PubTator, text mining | PubMed |
| Growth differentiation factor-11 inhibits the progression of acute myeloid leukemia and increases chemosensitivity by inhibiting cathepsin S. | Anticancer Drugs | 2026 | 42307925 | PubTator, text mining | PubMed |
| Growth differentiation factor 11 (GDF11) signaling in neural stem cell regulation: molecular and cellular insights. | Rev Neurosci | 2026 | 42299745 | PubTator, text mining | PubMed |
| A Multimodal Framework for Alzheimer's Prevention: Diet, Exercise, Fasting, Sleep, and Gut Microbiota. | Curr Alzheimer Res | 2026 | 42099162 | PubTator, text mining | PubMed |
1 to 10 of 1,347
See all 1,347 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10220
GET https://conductscience.org/api/genes/v1/10220/patents?page=2