Gene · 10221
TRIB1: tribbles pseudokinase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TRIB1: tribbles pseudokinase 1. Genes, record 10221. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10221
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96RU8 | Tribbles homolog 1 | 372 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents39
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641202 A2 | 2025-10-29 | 4874 | Q96RU8 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4874 | Q96RU8 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5332 | Q96RU8 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 92128 | Q96RU8 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 195099 | Q96RU8 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 11962 | Q96RU8 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 5332 | Q96RU8 | Espacenet |
| EP 3504344 A1 | 2019-07-03 | 1257 | Q96RU8 | Espacenet |
| JP 2018023373 A | 2018-02-15 | 28059 | Q96RU8 | Espacenet |
| US 9572897 B2 | 2017-02-21 | 5332 | Q96RU8 | Espacenet |
1 to 10 of 39
See all 39 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,523
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TRIB1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK063491 | Diabetes Research Center (DRC) | 24 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 9 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 7 | 2025 |
| R01DK062370 | Identifying Genes for Type 2 Diabetes: FUSION | 7 | 2025 |
| ZIAHG000024 | Genetic analysis of type II diabetes | 7 | 2025 |
| R01DK093757 | Genetic epidemiology of rare and regulatory variants for metabolic traits | 6 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 6 | 2025 |
| ZIABC008752 | Thyroid Hormone Nuclear Receptors in Health and Disease | 6 | 2025 |
| ZIAHL006170 | Cardiovascular Genomics and Bioinformatics projects | 6 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 1,523Source NIH's project files
See all 1,523 nih grantsPapers1,541
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Thyroxine enhances breast cancer cell survival and proliferation via TRβ1-Dependent PI3K/AKT signaling. | Mol Cell Endocrinol | 2027 | 42705592 | PubTator, text mining | PubMed |
| Systemic immune programming in the life course of childhood asthma: a new perspective on monocyte pre-activation and trained immunity. | Front Immunol | 2026 | 42812887 | PubTator, text mining | PubMed |
| Epigenome-Wide Association Study of Abdominal Aortic Aneurysm Identifies Central Role for Inflammatory Pathways. | Circulation | 2026 | 42808173 | PubTator, text mining | PubMed |
| Affinity selection mass spectrometry screening discovers new COP1 peptide binders. | RSC Chem Biol | 2026 | 42761335 | PubTator, text mining | PubMed |
| Integrated population-level and molecular evidence links nineteen aromatic amine antioxidants and six p-phenylenediamine quinones to thyroid homeostasis in older adults. | J Hazard Mater | 2026 | 42721831 | PubTator, text mining | PubMed |
| Bidirectional Regulation of c-Myc and TRB1 Establishes Oncogenic Reciprocal Regulation. | Biol Pharm Bull | 2026 | 42669521 | PubTator, text mining | PubMed |
| Integration of Bulk RNA Sequencing and Single-Cell Sequencing to Identify Prognostic Genes Associated With MCDRGs in Neuroblastoma. | FASEB J | 2026 | 42600038 | PubTator, text mining | PubMed |
| Tribbles pseudokinases: Fine tuning of cell signaling with implications in metabolism, inflammation and cancer. | Curr Opin Cell Biol | 2026 | 42492374 | PubTator, text mining | PubMed |
| Genetic and genomic insights across the steatotic liver disease spectrum. | Clin Mol Hepatol | 2026 | 42366560 | PubTator, text mining | PubMed |
| Integrative In Silico and Experimental Evaluation of Borassus flabellifer Immature Endosperm for Dual Modulation of Diabetes and Hypothyroidism. | Nutrients | 2026 | 42356318 | PubTator, text mining | PubMed |
1 to 10 of 1,541
See all 1,541 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10221
GET https://conductscience.org/api/genes/v1/10221/patents?page=2