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Gene · 10221

TRIB1: tribbles pseudokinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRIB1: tribbles pseudokinase 1. Genes, record 10221. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10221

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Gene

Symbol
TRIB1
HGNC
Name
tribbles pseudokinase 1
HGNC
NCBI Gene ID
10221
NCBI Gene
HGNC ID
HGNC:16891
HGNC
Ensembl
ENSG00000173334
NCBI Gene
Aliases
C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96RU8Tribbles homolog 13725Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641202 A22025-10-294874Q96RU8Espacenet
KR 1020250017231 A2025-02-044874Q96RU8Espacenet
US 11564998 B22023-01-315332Q96RU8Espacenet
US 11446398 B22022-09-2092128Q96RU8Espacenet
JP 2022524081 A2022-04-27195099Q96RU8Espacenet
US 11078247 B22021-08-0311962Q96RU8Espacenet
US 10463751 B22019-11-055332Q96RU8Espacenet
EP 3504344 A12019-07-031257Q96RU8Espacenet
JP 2018023373 A2018-02-1528059Q96RU8Espacenet
US 9572897 B22017-02-215332Q96RU8Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,523

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRIB1 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)242025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal92025
P30DK020572Michigan Diabetes Research Center (MDRC)72025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION72025
ZIAHG000024Genetic analysis of type II diabetes72025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits62025
UL1TR001881UCLA Clinical and Translational Science Institute62025
ZIABC008752Thyroid Hormone Nuclear Receptors in Health and Disease62025
ZIAHL006170Cardiovascular Genomics and Bioinformatics projects62025
P30CA016520Abramson Cancer Center Support Grant52025

1 to 10 of 1,523Source NIH's project files

See all 1,523 nih grants

Papers1,541

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Thyroxine enhances breast cancer cell survival and proliferation via TRβ1-Dependent PI3K/AKT signaling.Mol Cell Endocrinol202742705592PubTator, text miningPubMed
Systemic immune programming in the life course of childhood asthma: a new perspective on monocyte pre-activation and trained immunity.Front Immunol202642812887PubTator, text miningPubMed
Epigenome-Wide Association Study of Abdominal Aortic Aneurysm Identifies Central Role for Inflammatory Pathways.Circulation202642808173PubTator, text miningPubMed
Affinity selection mass spectrometry screening discovers new COP1 peptide binders.RSC Chem Biol202642761335PubTator, text miningPubMed
Integrated population-level and molecular evidence links nineteen aromatic amine antioxidants and six p-phenylenediamine quinones to thyroid homeostasis in older adults.J Hazard Mater202642721831PubTator, text miningPubMed
Bidirectional Regulation of c-Myc and TRB1 Establishes Oncogenic Reciprocal Regulation.Biol Pharm Bull202642669521PubTator, text miningPubMed
Integration of Bulk RNA Sequencing and Single-Cell Sequencing to Identify Prognostic Genes Associated With MCDRGs in Neuroblastoma.FASEB J202642600038PubTator, text miningPubMed
Tribbles pseudokinases: Fine tuning of cell signaling with implications in metabolism, inflammation and cancer.Curr Opin Cell Biol202642492374PubTator, text miningPubMed
Genetic and genomic insights across the steatotic liver disease spectrum.Clin Mol Hepatol202642366560PubTator, text miningPubMed
Integrative In Silico and Experimental Evaluation of Borassus flabellifer Immature Endosperm for Dual Modulation of Diabetes and Hypothyroidism.Nutrients202642356318PubTator, text miningPubMed

1 to 10 of 1,541

See all 1,541 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10221

GET https://conductscience.org/api/genes/v1/10221/patents?page=2