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MSLN: mesothelin

1 protein, 245 patents, 5 drugs, 30 trials, 2,285 NIH grants and 5,800 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMSLNHGNC
NamemesothelinHGNC
NCBI Gene ID10232NCBI Gene
HGNC IDHGNC:7371HGNC
EnsemblENSG00000102854NCBI Gene
AliasesCAK1, MPF, SMRPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13421Mesothelin62212Ensembl, GeneID, HGNCUniProt

Patents 245

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026210031 A12026-10-081180Q13421Espacenet
EP 4753743 A12026-06-10139Q13421Espacenet
US 12612463 B22026-04-282Q13421Espacenet
EP 4727574 A22026-04-221Q13421Espacenet
EP 4712986 A12026-03-2523Q13421Espacenet
JP 2026053377 A2026-03-252Q13421Espacenet
JP 2026004568 A2026-01-1453287Q13421Espacenet
JP 2026004568 A2026-01-1453289Q13421Espacenet
JP 2026004568 A2026-01-1453290Q13421Espacenet
JP 2025536561 A2025-11-0760Q13421Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMATUXIMABCHEMBL1742984Mesothelin inhibitorINHIBITORChEMBL
ANETUMAB RAVTANSINECHEMBL2109629Mesothelin binding agentBINDING AGENTChEMBL
LMB-100CHEMBL4297777Mesothelin binding agentBINDING AGENTChEMBL
RG-7600CHEMBL2109281Mesothelin binding agentBINDING AGENTChEMBL
SS1(DSFV)-PE38CHEMBL2109516Mesothelin binding agentBINDING AGENTChEMBL

Trials 30

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05375825LMB-100PHASE1ClinicalTrials.gov
NCT04840615LMB-100PHASE12024-02-02ClinicalTrials.gov
NCT04034238LMB-100PHASE12022-02-08ClinicalTrials.gov
NCT04027946LMB-100PHASE22023-07-18ClinicalTrials.gov
NCT03926143ANETUMAB RAVTANSINEPHASE22023-08-04ClinicalTrials.gov
NCT03816358ANETUMAB RAVTANSINEPHASE1ClinicalTrials.gov
NCT03644550LMB-100PHASE22021-12-02ClinicalTrials.gov
NCT03587311ANETUMAB RAVTANSINEPHASE2ClinicalTrials.gov
NCT03455556ANETUMAB RAVTANSINEPHASE12020-05-15ClinicalTrials.gov
NCT03436732LMB-100PHASE12019-11-22ClinicalTrials.gov

NIH grants 2285

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant972,025NIH's project files
ZIABC010816Adoptive cell therapy for malignant mesothelioma and other mesothelin expressing442,025NIH's project files
P30CA016672Cancer Center Support Grant422,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant352,025NIH's project files
P30CA006973Regional Oncology Research Center342,025NIH's project files
ZIABC010891Development of antibody engineering-based cancer therapies302,025NIH's project files
T32CA009501Surgical Oncology Research Training Grant212,025NIH's project files
ZIDBC011540Thoracic and Gastrointestinal Malignancies Branch Clinical Core192,025NIH's project files
P01CA214278Enhancing Chimeric Antigen Receptor T Cell Therapies for HematologicMalignancies: Beyond CART 19182,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program112,025NIH's project files

Papers 5800

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823085PubTator, text miningPubMed
42814277PubTator, text miningPubMed
42798783PubTator, text miningPubMed
42779343PubTator, text miningPubMed
42758196PubTator, text miningPubMed
42743086PubTator, text miningPubMed
42690517PubTator, text miningPubMed
42681683PubTator, text miningPubMed
42681680PubTator, text miningPubMed
42670211PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license