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CDK8: cyclin dependent kinase 8
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Gene · 1024

Papers2,191

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,191

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TitleJournalYearPMIDFound bySource
Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets.Cell Rep Med202642753723PubTator, text miningPubMed
Targeting epigenetic regulators induces transcription-replication conflicts to overcome ATR inhibitor resistance.Nucleic Acids Res202642621735PubTator, text miningPubMed
Retraction Note: NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells.Exp Mol Med202642613452PubTator, text miningPubMed
Synthesis and antitumoral evaluation of 3',4'-unsaturated nucleoside analogues bearing a chlorinated remdesivir-like base.Bioorg Chem202642607445PubTator, text miningPubMed
Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML.Cells202642587822PubTator, text miningPubMed
An integrated deep learning and molecular dynamics pipeline for the discovery of novel CDK8 inhibitors against acute myeloid leukaemia.SAR QSAR Environ Res202642565435PubTator, text miningPubMed
Discovery of a potent dual-target CDK8 and cyclin C PROTAC degrader for the treatment of colorectal cancer.RSC Med Chem202642519713PubTator, text miningPubMed
The Transcriptional Kinases CDK8/19 in the Regulation of the Macrophage Inflammatory Response.Acta Naturae202642499677PubTator, text miningPubMed
CDK8 Inhibition Releases the Muscle Differentiation Block in Fusion-Driven Alveolar Rhabdomyosarcoma.Cancer Discov202642447071PubTator, text miningPubMed
CDK8 Inhibition Induces Mediator Trapping and Impairment of the EWSR1::FLI1 Transcriptional Program in Ewing Sarcoma.Cancer Discov202642447057PubTator, text miningPubMed
CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC.EMBO J202642436354PubTator, text miningPubMed
ClSAMBA regulates ray floret growth and flowering time in Chrysanthemum lavandulifolium.Plant Sci202642419490PubTator, text miningPubMed
In Vitro and In Silico Assessment of Anticancer Activity of Venom-Derived and Biomimetic Neurotransmitter Inhibitor Pentapeptides.Cell Biochem Biophys202642412310PubTator, text miningPubMed
The Role of the Mediator Complex in Modulating CjXDR1-Induced Multidrug Resistance and Virulence in Clarireedia jacksonii.Phytopathology202642308477PubTator, text miningPubMed
Design, synthesis and biological evaluation of novel CDK8/BRD4 dual inhibitors.Bioorg Med Chem Lett202642285310PubTator, text miningPubMed
Amplification of MED30 at chromosome 8q24 reprograms MYC binding to low-affinity oncogenic enhancers in cancer cells.Cell Rep202642275218PubTator, text miningPubMed
The paradox of miR-107 in oncology: dual roles as a tumor suppressor and oncomiR.Cancer Gene Ther202642230820PubTator, text miningPubMed
Modeling stimulus-induced stress responses in microglia-like cells using a commercial iPSC-dCas9-KRAB line.Stem Cell Res202642214129PubTator, text miningPubMed
Cyclin E modulates vulnerability to CDC7 kinase inhibition.Oncogenesis202642031714PubTator, text miningPubMed
Computational Discovery of CDK8 Inhibitors From Natural Compounds in NPACT Database.Chem Biodivers202641983412PubTator, text miningPubMed

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  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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