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Gene · 1024

CDK8: cyclin dependent kinase 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDK8: cyclin dependent kinase 8. Genes, record 1024. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1024

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Gene

Symbol
CDK8
HGNC
Name
cyclin dependent kinase 8
HGNC
NCBI Gene ID
1024
NCBI Gene
HGNC ID
HGNC:1779
HGNC
Ensembl
ENSG00000132964
NCBI Gene
Aliases
IDDHBA, K35
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49336Cyclin-dependent kinase 846436Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2910797P49336Espacenet
JP 2025517969 A2025-06-1210797P49336Espacenet
JP 2024123008 A2024-09-105795P49336Espacenet
US 11471477 B22022-10-1846P49336Espacenet
US 11446398 B22022-09-2021346P49336Espacenet
JP 2022524081 A2022-04-27124317P49336Espacenet
US 11078247 B22021-08-031948P49336Espacenet
JP 2020534354 A2020-11-2646P49336Espacenet
EP 3684420 A12020-07-2946P49336Espacenet
US 10508121 B22019-12-171P49336Espacenet

1 to 10 of 31

See all 31 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AT-7519CHEMBL445813Cyclin-dependent kinase inhibitorINHIBITORChEMBL
AZD-5438CHEMBL488436Cyclin-dependent kinase inhibitorINHIBITORChEMBL
PHA-793887CHEMBL1230607Cyclin-dependent kinase inhibitorINHIBITORChEMBL
RONICICLIBCHEMBL4442620Cyclin-dependent kinase inhibitorINHIBITORChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02522910RONICICLIBPHASE1/PHASE2ClinicalTrials.gov
NCT02161419RONICICLIBPHASE2ClinicalTrials.gov
NCT01652144AT-7519PHASE2ClinicalTrials.gov
NCT01627054AT-7519PHASE2ClinicalTrials.gov
NCT01573338RONICICLIBPHASE1/PHASE2ClinicalTrials.gov
NCT01188252RONICICLIBPHASE1ClinicalTrials.gov
NCT01183949AT-7519PHASE1/PHASE2ClinicalTrials.gov

NIH grants1,456

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDK8 papersNewest fiscal year
P30CA008748Cancer Center Support Grant162025
P30CA016672Cancer Center Support Grant122025
P30CA046934University of Colorado Cancer Center Support Grant122025
R35GM139550Mechanisms of RNA polymerase II transcription regulation92025
R01HD087417Molecular basis of MED12 in the pathogenesis of uterine fibroids82025
P40OD018537Bloomington Drosophila Stock Center at Indiana University72025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)52025
T32CA009172Physician Scientist Training in Cancer Research52025
P30AI027763UCSF-Bay Area Center for AIDS Research42025

1 to 10 of 1,456Source NIH's project files

See all 1,456 nih grants

Papers2,191

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets.Cell Rep Med202642753723PubTator, text miningPubMed
Targeting epigenetic regulators induces transcription-replication conflicts to overcome ATR inhibitor resistance.Nucleic Acids Res202642621735PubTator, text miningPubMed
Retraction Note: NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells.Exp Mol Med202642613452PubTator, text miningPubMed
Synthesis and antitumoral evaluation of 3',4'-unsaturated nucleoside analogues bearing a chlorinated remdesivir-like base.Bioorg Chem202642607445PubTator, text miningPubMed
Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML.Cells202642587822PubTator, text miningPubMed
An integrated deep learning and molecular dynamics pipeline for the discovery of novel CDK8 inhibitors against acute myeloid leukaemia.SAR QSAR Environ Res202642565435PubTator, text miningPubMed
Discovery of a potent dual-target CDK8 and cyclin C PROTAC degrader for the treatment of colorectal cancer.RSC Med Chem202642519713PubTator, text miningPubMed
The Transcriptional Kinases CDK8/19 in the Regulation of the Macrophage Inflammatory Response.Acta Naturae202642499677PubTator, text miningPubMed
CDK8 Inhibition Releases the Muscle Differentiation Block in Fusion-Driven Alveolar Rhabdomyosarcoma.Cancer Discov202642447071PubTator, text miningPubMed
CDK8 Inhibition Induces Mediator Trapping and Impairment of the EWSR1::FLI1 Transcriptional Program in Ewing Sarcoma.Cancer Discov202642447057PubTator, text miningPubMed

1 to 10 of 2,191

See all 2,191 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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