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CDK9: cyclin dependent kinase 9

1 protein, 44 patents, 11 drugs, 87 trials, 3,784 NIH grants and 6,198 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCDK9HGNC
Namecyclin dependent kinase 9HGNC
NCBI Gene ID1025NCBI Gene
HGNC IDHGNC:1780HGNC
EnsemblENSG00000136807NCBI Gene
AliasesC-2k, CDC2L4, CTK1, PITALRE, TAKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P50750Cyclin-dependent kinase 937228Ensembl, GeneID, HGNCUniProt

Patents 44

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12534732 B22026-01-27909P50750Espacenet
JP 2026012378 A2026-01-23909P50750Espacenet
US 12516329 B22026-01-06909P50750Espacenet
EP 4670792 A22025-12-31909P50750Espacenet
EP 4650780 A22025-11-199284P50750Espacenet
KR 1020250160362 A2025-11-12909P50750Espacenet
JP 2025517970 A2025-06-129284P50750Espacenet
JP 2025512950 A2025-04-2211P50750Espacenet
KR 1020250004725 A2025-01-0811P50750Espacenet
US 12139713 B22024-11-12909P50750Espacenet

Drugs 11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALVOCIDIBCHEMBL428690Cyclin-dependent kinase 9 inhibitorINHIBITORChEMBL
AT-7519CHEMBL445813Cyclin-dependent kinase inhibitorINHIBITORChEMBL
AZD-5438CHEMBL488436Cyclin-dependent kinase inhibitorINHIBITORChEMBL
BMS-387032CHEMBL296468Cyclin-dependent kinase 9 inhibitorINHIBITORChEMBL
DINACICLIBCHEMBL2103840Cyclin-dependent kinase 9 inhibitorINHIBITORChEMBL
PHA-793887CHEMBL1230607Cyclin-dependent kinase inhibitorINHIBITORChEMBL
RGB-286638CHEMBL3545083Cyclin-dependent kinase 9 inhibitorINHIBITORChEMBL
RIVICICLIBCHEMBL3545283Cyclin-dependent kinase 9 inhibitorINHIBITORChEMBL
RONICICLIBCHEMBL4442620Cyclin-dependent kinase inhibitorINHIBITORChEMBL
SELICICLIBCHEMBL14762Cyclin-dependent kinase 9 inhibitorINHIBITORChEMBL

Trials 87

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04493099ALVOCIDIBPHASE1/PHASE2ClinicalTrials.gov
NCT03969420ALVOCIDIBPHASE22022-10-19ClinicalTrials.gov
NCT03904628ZOTIRACICLIBPHASE1ClinicalTrials.gov
NCT03774446SELICICLIBPHASE2ClinicalTrials.gov
NCT03738111ZOTIRACICLIBPHASE1ClinicalTrials.gov
NCT03593915ALVOCIDIBPHASE1/PHASE22022-10-21ClinicalTrials.gov
NCT03563560ALVOCIDIBPHASE1ClinicalTrials.gov
NCT03484520DINACICLIBPHASE1ClinicalTrials.gov
NCT03441555ALVOCIDIBPHASE1ClinicalTrials.gov
NCT03298984ALVOCIDIBPHASE12021-05-24ClinicalTrials.gov

NIH grants 3784

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant502,025NIH's project files
P30CA016672Cancer Center Support Grant442,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research412,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant182,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant182,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias162,025NIH's project files
P30CA014051Cancer Center Support (Core) Grant152,025NIH's project files
P30CA016059Massey Cancer Center - Cancer Center Support Grant152,025NIH's project files
P30AI036219Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)142,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program142,025NIH's project files

Papers 6198

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825898PubTator, text miningPubMed
42823736PubTator, text miningPubMed
42822357PubTator, text miningPubMed
42818227PubTator, text miningPubMed
42815276PubTator, text miningPubMed
42814811PubTator, text miningPubMed
42807931PubTator, text miningPubMed
42748911PubTator, text miningPubMed
42718694PubTator, text miningPubMed
42650051PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license