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Gene · 10252

SPRY1: sprouty RTK signaling antagonist 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SPRY1: sprouty RTK signaling antagonist 1. Genes, record 10252. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10252

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Gene

Symbol
SPRY1
HGNC
Name
sprouty RTK signaling antagonist 1
HGNC
NCBI Gene ID
10252
NCBI Gene
HGNC ID
HGNC:11269
HGNC
Ensembl
ENSG00000164056
NCBI Gene
Aliases
hSPRY1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43609Protein sprouty homolog 13190Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465361O43609Espacenet
JP 2026004568 A2026-01-1465362O43609Espacenet
EP 4641202 A22025-10-29363O43609Espacenet
JP 2025529142 A2025-09-044433O43609Espacenet
US 12371689 B22025-07-294433O43609Espacenet
JP 2025506727 A2025-03-1365O43609Espacenet
KR 1020250017231 A2025-02-04363O43609Espacenet
US 11701385 B22023-07-18112O43609Espacenet
JP 2022147356 A2022-10-06290O43609Espacenet
US 11446398 B22022-09-2083689O43609Espacenet

1 to 10 of 56

See all 56 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants949

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSPRY1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant52025
P20GM121301Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks42025
P30CA016058Cancer Center Support Grant42025
R01HL140934Exploring the Molecular Physiology of Atrial Fibrillation42025
P30CA008748Cancer Center Support Grant32025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025
R25NS076445Summer Program for Undergraduate Rising Stars (SPURS), a Columbia University biomedical sciences pipeline program32025
U54GM115516Northern New England Clinical and Translational Research Network32025
I01BX000824Sprouty: Putative Oncogene in Colorectal Cancer22025
P01AG036695Molecular Regulation of Stem Cell Aging22025

1 to 10 of 949Source NIH's project files

See all 949 nih grants

Papers1,074

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integration of Single-Cell Transcriptomics and Network-Based Machine Learning Identifies Bone Marrow Mesenchymal Stem Cell-Associated Candidate Biomarkers and Exploratory Immune Correlates in Osteoarthritis.
Curr Gene Ther202642634547PubTator, text miningPubMed
Correction: Suppression of Spry1 reduces HIF1α‑dependent glycolysis and impairs angiogenesis in BRAF‑mutant cutaneous melanoma.J Exp Clin Cancer Res202642625217PubTator, text miningPubMed
Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma.Front Oncol202642528570PubTator, text miningPubMed
Identification of miR-21-5p and miR-21-3p regulated hub genes and drug repurposing targets in cervical cancer: an integrative computational analysis.Naunyn Schmiedebergs Arch Pharmacol202642477186PubTator, text miningPubMed
Aberrant O-glycosylation genes and miR-21-5p targets define a molecular signature of tumor aggressiveness in triple-negative breast cancer.Glycobiology202642348735PubTator, text miningPubMed
3D-printed dictamni-calcium silicate scaffolds modulate the osteoimmune microenvironment and enhance macrophage-derived exosomal miR-21 signaling in vascularized bone regeneration.J Nanobiotechnology202642098777PubTator, text miningPubMed
miR-18a-5p promotes phenotypic transformation of airway smooth muscle cells by targeting SPRY1 to activate the RAS-MAPK pathway.Front Genet202641938622PubTator, text miningPubMed
MicroRNA Regulation in Kidney Interstitial Fibrosis.Epigenomes202641892370PubTator, text miningPubMed
Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review).Int J Oncol202641860028PubTator, text miningPubMed
Current research status and challenges of neoadjuvant immunotherapy for Esophageal squamous cell carcinoma.Biochim Biophys Acta Rev Cancer202641806941PubTator, text miningPubMed

1 to 10 of 1,074

See all 1,074 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10252

GET https://conductscience.org/api/genes/v1/10252/patents?page=2