Gene · 10252
SPRY1: sprouty RTK signaling antagonist 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SPRY1: sprouty RTK signaling antagonist 1. Genes, record 10252. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10252
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43609 | Protein sprouty homolog 1 | 319 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65361 | O43609 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 65362 | O43609 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 363 | O43609 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4433 | O43609 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4433 | O43609 | Espacenet |
| JP 2025506727 A | 2025-03-13 | 65 | O43609 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 363 | O43609 | Espacenet |
| US 11701385 B2 | 2023-07-18 | 112 | O43609 | Espacenet |
| JP 2022147356 A | 2022-10-06 | 290 | O43609 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 83689 | O43609 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants949
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SPRY1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P20GM121301 | Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| R01HL140934 | Exploring the Molecular Physiology of Atrial Fibrillation | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 3 | 2025 |
| R25NS076445 | Summer Program for Undergraduate Rising Stars (SPURS), a Columbia University biomedical sciences pipeline program | 3 | 2025 |
| U54GM115516 | Northern New England Clinical and Translational Research Network | 3 | 2025 |
| I01BX000824 | Sprouty: Putative Oncogene in Colorectal Cancer | 2 | 2025 |
| P01AG036695 | Molecular Regulation of Stem Cell Aging | 2 | 2025 |
1 to 10 of 949Source NIH's project files
See all 949 nih grantsPapers1,074
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Integration of Single-Cell Transcriptomics and Network-Based Machine Learning Identifies Bone Marrow Mesenchymal Stem Cell-Associated Candidate Biomarkers and Exploratory Immune Correlates in Osteoarthritis. | Curr Gene Ther | 2026 | 42634547 | PubTator, text mining | PubMed |
| Correction: Suppression of Spry1 reduces HIF1α‑dependent glycolysis and impairs angiogenesis in BRAF‑mutant cutaneous melanoma. | J Exp Clin Cancer Res | 2026 | 42625217 | PubTator, text mining | PubMed |
| Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma. | Front Oncol | 2026 | 42528570 | PubTator, text mining | PubMed |
| Identification of miR-21-5p and miR-21-3p regulated hub genes and drug repurposing targets in cervical cancer: an integrative computational analysis. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42477186 | PubTator, text mining | PubMed |
| Aberrant O-glycosylation genes and miR-21-5p targets define a molecular signature of tumor aggressiveness in triple-negative breast cancer. | Glycobiology | 2026 | 42348735 | PubTator, text mining | PubMed |
| 3D-printed dictamni-calcium silicate scaffolds modulate the osteoimmune microenvironment and enhance macrophage-derived exosomal miR-21 signaling in vascularized bone regeneration. | J Nanobiotechnology | 2026 | 42098777 | PubTator, text mining | PubMed |
| miR-18a-5p promotes phenotypic transformation of airway smooth muscle cells by targeting SPRY1 to activate the RAS-MAPK pathway. | Front Genet | 2026 | 41938622 | PubTator, text mining | PubMed |
| MicroRNA Regulation in Kidney Interstitial Fibrosis. | Epigenomes | 2026 | 41892370 | PubTator, text mining | PubMed |
| Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review). | Int J Oncol | 2026 | 41860028 | PubTator, text mining | PubMed |
| Current research status and challenges of neoadjuvant immunotherapy for Esophageal squamous cell carcinoma. | Biochim Biophys Acta Rev Cancer | 2026 | 41806941 | PubTator, text mining | PubMed |
1 to 10 of 1,074
See all 1,074 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10252
GET https://conductscience.org/api/genes/v1/10252/patents?page=2