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Gene · 10253

SPRY2: sprouty RTK signaling antagonist 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SPRY2: sprouty RTK signaling antagonist 2. Genes, record 10253. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10253

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Gene

Symbol
SPRY2
HGNC
Name
sprouty RTK signaling antagonist 2
HGNC
NCBI Gene ID
10253
NCBI Gene
HGNC ID
HGNC:11270
HGNC
Ensembl
ENSG00000136158
NCBI Gene
Aliases
IGAN3, hSPRY2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43597Protein sprouty homolog 23155Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465366O43597Espacenet
JP 2026004568 A2026-01-1465367O43597Espacenet
JP 2026004568 A2026-01-1465368O43597Espacenet
EP 4650780 A22025-11-199881O43597Espacenet
JP 2025529142 A2025-09-044434O43597Espacenet
US 12371689 B22025-07-294434O43597Espacenet
JP 2025517970 A2025-06-129881O43597Espacenet
US 11701385 B22023-07-18113O43597Espacenet
US 11446398 B22022-09-2083696O43597Espacenet
US 11446398 B22022-09-2083697O43597Espacenet

1 to 10 of 58

See all 58 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,473

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSPRY2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant132025
P30CA016672Cancer Center Support Grant132025
P30CA068485Cancer Center Support Grant62025
P30DK026743UCSF Liver Center62025
P30CA016087Cancer Center Support Grant52025
P30DK063491Diabetes Research Center (DRC)42025
P30ES005605Environmental Health Sciences Research Center42025
P30CA016058Cancer Center Support Grant32025
P30CA016359Cancer Center Support Grant32025
P30CA056036Translational Research in Cancer32025

1 to 10 of 1,473Source NIH's project files

See all 1,473 nih grants

Papers1,626

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effects of Regulating SPRY2 and miR-590-5p Expression on Autophagy in Human Osteoarthritis Model Chondrocytes.J Vis Exp202642612092PubTator, text miningPubMed
Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.Mol Genet Genomics202642334621PubTator, text miningPubMed
Emergence of Sprouty role from the signaling interplay of DUSP1 and DUSP4 interactions in NSCLC pathogenesis.NPJ Syst Biol Appl202642140968PubTator, text miningPubMed
Screening for differentially expressed genes in retinoblastoma gene chips through the GEO database and validation in clinical settings.Int J Ophthalmol202642039963PubTator, text miningPubMed
Machine learning model based on plasma proteomics for the identification of Parkinson's disease.Brain202642015416PubTator, text miningPubMed
ERKed by too much signaling: from oncogenic driver to therapeutic vulnerability.Cell Mol Life Sci202641865130PubTator, text miningPubMed
Unraveling the genetic links between stature and disease in East Asians: A multi-biobank genetic correlation and risk prediction study.PLoS Genet202641824406PubTator, text miningPubMed
Transcriptional coordination in multicellular lineage differentiation during lung organogenesis: deciphering the role of epithelial cells as a microenvironmental regulatory hub.Front Cell Dev Biol202641799436PubTator, text miningPubMed
Exosome-delivered bioactive molecules regulate macrophage polarization in atherosclerosis and myocardial infarction: mechanisms and therapeutic potential.Front Cardiovasc Med202641798608PubTator, text miningPubMed
Calcium release channel deficiency syndrome in patients diagnosed with idiopathic ventricular fibrillation and decedents classified as sudden unexplained death in the young.Europace202641785165PubTator, text miningPubMed

1 to 10 of 1,626

See all 1,626 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10253

GET https://conductscience.org/api/genes/v1/10253/patents?page=2