Gene · 10253
SPRY2: sprouty RTK signaling antagonist 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SPRY2: sprouty RTK signaling antagonist 2. Genes, record 10253. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10253
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43597 | Protein sprouty homolog 2 | 315 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65366 | O43597 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 65367 | O43597 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 65368 | O43597 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9881 | O43597 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4434 | O43597 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4434 | O43597 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9881 | O43597 | Espacenet |
| US 11701385 B2 | 2023-07-18 | 113 | O43597 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 83696 | O43597 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 83697 | O43597 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,473
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SPRY2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| P30DK026743 | UCSF Liver Center | 6 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 5 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 4 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016359 | Cancer Center Support Grant | 3 | 2025 |
| P30CA056036 | Translational Research in Cancer | 3 | 2025 |
1 to 10 of 1,473Source NIH's project files
See all 1,473 nih grantsPapers1,626
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Effects of Regulating SPRY2 and miR-590-5p Expression on Autophagy in Human Osteoarthritis Model Chondrocytes. | J Vis Exp | 2026 | 42612092 | PubTator, text mining | PubMed |
| Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology. | Mol Genet Genomics | 2026 | 42334621 | PubTator, text mining | PubMed |
| Emergence of Sprouty role from the signaling interplay of DUSP1 and DUSP4 interactions in NSCLC pathogenesis. | NPJ Syst Biol Appl | 2026 | 42140968 | PubTator, text mining | PubMed |
| Screening for differentially expressed genes in retinoblastoma gene chips through the GEO database and validation in clinical settings. | Int J Ophthalmol | 2026 | 42039963 | PubTator, text mining | PubMed |
| Machine learning model based on plasma proteomics for the identification of Parkinson's disease. | Brain | 2026 | 42015416 | PubTator, text mining | PubMed |
| ERKed by too much signaling: from oncogenic driver to therapeutic vulnerability. | Cell Mol Life Sci | 2026 | 41865130 | PubTator, text mining | PubMed |
| Unraveling the genetic links between stature and disease in East Asians: A multi-biobank genetic correlation and risk prediction study. | PLoS Genet | 2026 | 41824406 | PubTator, text mining | PubMed |
| Transcriptional coordination in multicellular lineage differentiation during lung organogenesis: deciphering the role of epithelial cells as a microenvironmental regulatory hub. | Front Cell Dev Biol | 2026 | 41799436 | PubTator, text mining | PubMed |
| Exosome-delivered bioactive molecules regulate macrophage polarization in atherosclerosis and myocardial infarction: mechanisms and therapeutic potential. | Front Cardiovasc Med | 2026 | 41798608 | PubTator, text mining | PubMed |
| Calcium release channel deficiency syndrome in patients diagnosed with idiopathic ventricular fibrillation and decedents classified as sudden unexplained death in the young. | Europace | 2026 | 41785165 | PubTator, text mining | PubMed |
1 to 10 of 1,626
See all 1,626 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10253
GET https://conductscience.org/api/genes/v1/10253/patents?page=2