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Gene · 10273

STUB1: STIP1 homology and U-box containing protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. STUB1: STIP1 homology and U-box containing protein 1. Genes, record 10273. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10273

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Gene

Symbol
STUB1
HGNC
Name
STIP1 homology and U-box containing protein 1
HGNC
NCBI Gene ID
10273
NCBI Gene
HGNC ID
HGNC:11427
HGNC
Ensembl
ENSG00000103266
NCBI Gene
Aliases
CHIP, HSPABP2, NY-CO-7, SCA48, SCAR16, SDCCAG7, UBOX1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UNE7E3 ubiquitin-protein ligase CHIP30327Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026514437 A2026-05-1110Q9UNE7Espacenet
JP 2026507518 A2026-03-04145Q9UNE7Espacenet
EP 4687954 A22026-02-1110Q9UNE7Espacenet
JP 2026004568 A2026-01-1465637Q9UNE7Espacenet
EP 4665771 A12025-12-24145Q9UNE7Espacenet
EP 4650780 A22025-11-19457Q9UNE7Espacenet
EP 4580648 A22025-07-093Q9UNE7Espacenet
JP 2025517970 A2025-06-12457Q9UNE7Espacenet
WO 2025101862 A12025-05-157Q9UNE7Espacenet
US 11860162 B22024-01-021554Q9UNE7Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,081

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSTUB1 papersNewest fiscal year
R01NS059690Molecular Chaperones and Small Molecules132025
P30CA016672Cancer Center Support Grant62025
P30DK026743UCSF Liver Center52025
P30CA010815Consolidated Basic Cancer Research Program42025
R01NS073899The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function42025
R35GM119544Investigation into protein quality control pathways in Dictyostelium discoideum42025
P30CA023168Cancer Center Support Grant32025
P30CA093373Cancer Center Support Grant P3032025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
R01GM094231COMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATA32025

1 to 10 of 1,081Source NIH's project files

See all 1,081 nih grants

Papers1,745

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ATXN8OS Intermediate Expansion Acts as a Genetic Modifier in Spinocerebellar Ataxia Type 48 (SCA48/STUB1).Mov Disord202642768770PubTator, text miningPubMed
Mitochondrial Dysfunction in Digenic TBP/STUB1 Spinocerebellar Ataxia.Mov Disord Clin Pract202642768734PubTator, text miningPubMed
Chaperone-assisted selective autophagy (CASA) in polyglutamine-related diseases: From mechanisms to therapeutic perspectives.J Huntingtons Dis202642690709PubTator, text miningPubMed
Targeting ADAR stability: a novel approach to combat glioblastoma.Front Oncol202642625588PubTator, text miningPubMed
AURKB-mediated phosphorylation of metabolic enzyme CD73 drives immune suppression and renal cell carcinoma progression.Cell Death Differ202642613426PubTator, text miningPubMed
Corrigendum to "Hyperoside impairs mitochondrial respiration in chronic myeloid leukemia by promoting STUB1-mediated ubiquitination and degradation of NOX4" [Toxicology and Applied Pharmacology 511 (2026) 117795].
Toxicol Appl Pharmacol202642607845PubTator, text miningPubMed
FGD5 regulates PGK1 ubiquitination to synergize with 2-deoxy-D-glucose in pancreatic ductal adenocarcinoma.Oncogene202642567886PubTator, text miningPubMed
Domain-dependent uncoupling of the co-chaperone and E3 ubiquitin ligase CHIP underlies heterogeneity in spinocerebellar ataxia 48.J Biol Chem202642567515PubTator, text miningPubMed
A de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells.bioRxiv202642538903PubTator, text miningPubMed
Arsenic trioxide promotes a glue‑like interaction to drive STUB1-mediated NPM-ALK degradation in ALK+ ALCL.Exp Hematol Oncol202642533362PubTator, text miningPubMed

1 to 10 of 1,745

See all 1,745 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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