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Gene · 10278

EFS: embryonal Fyn-associated substrate

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EFS: embryonal Fyn-associated substrate. Genes, record 10278. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10278

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Gene

Symbol
EFS
HGNC
Name
embryonal Fyn-associated substrate
HGNC
NCBI Gene ID
10278
NCBI Gene
HGNC ID
HGNC:16898
HGNC
Ensembl
ENSG00000100842
NCBI Gene
Aliases
CAS3, CASS3, EFS1, EFS2, HEFS, SIN
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43281Embryonal Fyn-associated substrate5610Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444915O43281Espacenet
EP 4650780 A22025-11-19364O43281Espacenet
EP 4583897 A12025-07-164O43281Espacenet
JP 2025517970 A2025-06-12364O43281Espacenet
US 11446398 B22022-09-2027153O43281Espacenet
JP 2022524081 A2022-04-27130124O43281Espacenet
JP 2019054813 A2019-04-11225350O43281Espacenet
JP 2017121241 A2017-07-13225350O43281Espacenet
JP 2015516143 A2015-06-08225350O43281Espacenet
EP 2607900 A12013-06-261049O43281Espacenet

1 to 10 of 17

See all 17 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants842

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEFS papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase142025
P30CA008748Cancer Center Support Grant62025
P30CA045508CSHL Cancer Center Support Grant62025
R35GM118174Mechanistic Investigation of RNA-Mediated Gene Regulation and Immunity62025
P01CA013106Targeting Transcription and Splicing in Cancer42025
P30CA014051Cancer Center Support (Core) Grant42025
P30CA021765Cancer Center Support Grant (CCSG)42025
P30CA068485Cancer Center Support Grant32025
R35GM118160CRISPR Capture, Destroy, and Counter-Attack Mechanisms32025
R35GM137883Generation of DNA memory by bacterial CRISPR-Cas9 systems32025

1 to 10 of 842Source NIH's project files

See all 842 nih grants

Papers1,523

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Inhibiting TNAP Attenuates the Aortic Valve Calcification and Reduces Oxidative Stress.Cells202642738837PubTator, text miningPubMed
Environmentally friendly solvents: the strategic and frontier fields of natural product extraction.Food Chem202642721589PubTator, text miningPubMed
Diverse routes to Cas3 activation in type I CRISPR-Cas immunity.Cell Rep202642721033PubTator, text miningPubMed
Recruitment of Cas3 enables DNA cleavage by the type I-A CRISPR-Cas system of Saccharolobus islandicus.Cell Rep202642570236PubTator, text miningPubMed
CRISPR-Cas systems as precision antimicrobials: Reversing the tide of antimicrobial resistance.Virus Res202642551559PubTator, text miningPubMed
Synergistic Inhibition of Colorectal Cancer Growth by Combined PI3K and COX-2 Blockade in Cell Lines and Patient-Derived Organoids.Pharmaceutics202642357299PubTator, text miningPubMed
Gigabase-scale deletion scanning of the human genome.bioRxiv202642282737PubTator, text miningPubMed
The effects of external electric fields on proteins.Chem Soc Rev202641995174PubTator, text miningPubMed
Correction: Sarman, E.; Asci, H. Cellular Anti-Apoptotic Effects of Dapagliflozin in Methotrexate-Induced Liver Toxicity: Bax/Bcl-2/Cyt-C/Cas-9/Cas-3 Signaling Pathway. Int. J. Mol. Sci. 2026, 27, 2110.
Int J Mol Sci202641977518PubTator, text miningPubMed
Targeting mitochondrial apoptosis in septic lung injury: protective potential of omega-3 fatty acids.Apoptosis202641894027PubTator, text miningPubMed

1 to 10 of 1,523

See all 1,523 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10278

GET https://conductscience.org/api/genes/v1/10278/patents