Gene · 10288
LILRB2: leukocyte immunoglobulin like receptor B2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LILRB2: leukocyte immunoglobulin like receptor B2. Genes, record 10288. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10288
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8N423 | Leukocyte immunoglobulin-like receptor subfamily B member 2 | 597 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025542200 A | 2025-12-25 | 390 | Q8N423 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5281 | Q8N423 | Espacenet |
| WO 2025232879 A1 | 2025-11-13 | 775 | Q8N423 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4867 | Q8N423 | Espacenet |
| JP 2025535192 A | 2025-10-22 | 60 | Q8N423 | Espacenet |
| WO 2025191142 A2 | 2025-09-18 | 64 | Q8N423 | Espacenet |
| KR 1020250129687 A | 2025-08-29 | 390 | Q8N423 | Espacenet |
| WO 2025126267 A | 2025-06-19 | 21 | Q8N423 | Espacenet |
| WO 2025127056 A | 2025-06-19 | 21 | Q8N423 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4867 | Q8N423 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,330
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LILRB2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| ZIABC010791 | Effects of genetic polymorphism in MHC, KIR, and related loci on human disease | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 5 | 2025 |
| R01AI044115 | Influences of HLA Class I Polymorphisms on immune responses | 5 | 2025 |
| P30AI027757 | University of Washington/Fred Hutch Center for AIDS Research | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| P01CA065493 | Off-the-Shelf Immune Effector Cells for Hematological Malignancies | 3 | 2025 |
| P30AI060354 | Harvard University Center for AIDS Research | 3 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 3 | 2025 |
1 to 10 of 1,330Source NIH's project files
See all 1,330 nih grantsPapers2,402
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Comprehensive Profiling of ac4C RNA Modification Identifies CERCAM in Cancer-Associated Fibroblasts as a Key Prognostic and Microenvironmental Regulator in Colorectal Cancer. | Cancer Rep (Hoboken) | 2026 | 42773727 | PubTator, text mining | PubMed |
| Advances in Immune Checkpoint Inhibitors for Cancer Treatment. | Cancers (Basel) | 2026 | 42279386 | PubTator, text mining | PubMed |
| Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration. | Transl Neurodegener | 2026 | 42231420 | PubTator, text mining | PubMed |
| Alpha-ketoglutarate Potentiates IL-1β Production and Suppressive Mechanisms of Myeloid-Derived Suppressor Cells by Altering Redox Metabolism and Inducing Autophagy. | Int J Biol Sci | 2026 | 42212338 | PubTator, text mining | PubMed |
| Validation of LILR antibody specificities and development of LILRA3-specific antibodies. | Front Immunol | 2026 | 42148084 | PubTator, text mining | PubMed |
| Identification of efficient geminivirus-derived LIR-elements for exogenous protein expression. | Arch Virol | 2026 | 42096057 | PubTator, text mining | PubMed |
| LILRB2+ monocytes reshape the immune activation landscape in immunotherapy with non-small cell lung cancer: Evidence from real-world cohorts and single-cell analyses. | Int J Biol Macromol | 2026 | 42069195 | PubTator, text mining | PubMed |
| High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third-trimester pregnancy. | Clin Transl Immunology | 2026 | 42065097 | PubTator, text mining | PubMed |
| LILRB2 inhibition by blocking antibody ES009 reprograms immunosuppressive myeloid cells and enhances T-cell-mediated tumor immunity. | Hum Vaccin Immunother | 2026 | 42007674 | PubTator, text mining | PubMed |
| High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third trimester pregnancy. | bioRxiv | 2026 | 41959409 | PubTator, text mining | PubMed |
1 to 10 of 2,402
See all 2,402 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10288
GET https://conductscience.org/api/genes/v1/10288/patents?page=2