ConductScience.org, home

Gene · 10288

LILRB2: leukocyte immunoglobulin like receptor B2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. LILRB2: leukocyte immunoglobulin like receptor B2. Genes, record 10288. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10288

On this page

Gene

Symbol
LILRB2
HGNC
Name
leukocyte immunoglobulin like receptor B2
HGNC
NCBI Gene ID
10288
NCBI Gene
HGNC ID
HGNC:6606
HGNC
Ensembl
ENSG00000131042
NCBI Gene
Aliases
CD85D, CD85d, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8N423Leukocyte immunoglobulin-like receptor subfamily B member 25977Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025542200 A2025-12-25390Q8N423Espacenet
EP 4650780 A22025-11-195281Q8N423Espacenet
WO 2025232879 A12025-11-13775Q8N423Espacenet
EP 4641201 A22025-10-294867Q8N423Espacenet
JP 2025535192 A2025-10-2260Q8N423Espacenet
WO 2025191142 A22025-09-1864Q8N423Espacenet
KR 1020250129687 A2025-08-29390Q8N423Espacenet
WO 2025126267 A2025-06-1921Q8N423Espacenet
WO 2025127056 A2025-06-1921Q8N423Espacenet
JP 2025517969 A2025-06-124867Q8N423Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,330

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLILRB2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
ZIABC010791Effects of genetic polymorphism in MHC, KIR, and related loci on human disease92025
P30CA016672Cancer Center Support Grant82025
P30CA016042Cancer Center Support Grant52025
R01AI044115Influences of HLA Class I Polymorphisms on immune responses52025
P30AI027757University of Washington/Fred Hutch Center for AIDS Research42025
P30CA016058Cancer Center Support Grant42025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies32025
P30AI060354Harvard University Center for AIDS Research32025
P30ES005605Environmental Health Sciences Research Center32025

1 to 10 of 1,330Source NIH's project files

See all 1,330 nih grants

Papers2,402

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Comprehensive Profiling of ac4C RNA Modification Identifies CERCAM in Cancer-Associated Fibroblasts as a Key Prognostic and Microenvironmental Regulator in Colorectal Cancer.Cancer Rep (Hoboken)202642773727PubTator, text miningPubMed
Advances in Immune Checkpoint Inhibitors for Cancer Treatment.Cancers (Basel)202642279386PubTator, text miningPubMed
Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration.Transl Neurodegener202642231420PubTator, text miningPubMed
Alpha-ketoglutarate Potentiates IL-1β Production and Suppressive Mechanisms of Myeloid-Derived Suppressor Cells by Altering Redox Metabolism and Inducing Autophagy.Int J Biol Sci202642212338PubTator, text miningPubMed
Validation of LILR antibody specificities and development of LILRA3-specific antibodies.Front Immunol202642148084PubTator, text miningPubMed
Identification of efficient geminivirus-derived LIR-elements for exogenous protein expression.Arch Virol202642096057PubTator, text miningPubMed
LILRB2+ monocytes reshape the immune activation landscape in immunotherapy with non-small cell lung cancer: Evidence from real-world cohorts and single-cell analyses.Int J Biol Macromol202642069195PubTator, text miningPubMed
High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third-trimester pregnancy.Clin Transl Immunology202642065097PubTator, text miningPubMed
LILRB2 inhibition by blocking antibody ES009 reprograms immunosuppressive myeloid cells and enhances T-cell-mediated tumor immunity.Hum Vaccin Immunother202642007674PubTator, text miningPubMed
High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third trimester pregnancy.bioRxiv202641959409PubTator, text miningPubMed

1 to 10 of 2,402

See all 2,402 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10288

GET https://conductscience.org/api/genes/v1/10288/patents?page=2