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Gene · 10298

PAK4: p21 (RAC1) activated kinase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PAK4: p21 (RAC1) activated kinase 4. Genes, record 10298. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10298

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Gene

Symbol
PAK4
HGNC
Name
p21 (RAC1) activated kinase 4
HGNC
NCBI Gene ID
10298
NCBI Gene
HGNC ID
HGNC:16059
HGNC
Ensembl
ENSG00000130669
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O96013Serine/threonine-protein kinase PAK 459149Ensembl, GeneID, HGNC

Source UniProt

Patents96

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12553882 B22026-02-171O96013Espacenet
EP 4650780 A22025-11-197529O96013Espacenet
EP 4641201 A22025-10-297526O96013Espacenet
JP 2025517969 A2025-06-127526O96013Espacenet
JP 2025517970 A2025-06-127529O96013Espacenet
US 12130292 B22024-10-2931O96013Espacenet
JP 2024123008 A2024-09-107505O96013Espacenet
JP 2024123008 A2024-09-107507O96013Espacenet
JP 2024123008 A2024-09-107508O96013Espacenet
JP 2024123008 A2024-09-107510O96013Espacenet

1 to 10 of 96

See all 96 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
PF-03758309CHEMBL3128043Serine/threonine-protein kinase PAK 4 inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants834

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePAK4 papersNewest fiscal year
R01GM102262LIM domain kinases: regulation and substrate recognition112025
P30CA008748Cancer Center Support Grant82025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30CA016672Cancer Center Support Grant62025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
P50CA116201Mayo Clinic Breast Cancer SPORE42025
R01GM086858New Molecular Probes For Protein Kinases42025
P30CA016058Cancer Center Support Grant32025
P30CA072720Cancer Center Support Grant32025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)32025

1 to 10 of 834Source NIH's project files

See all 834 nih grants

Papers1,639

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PAK4 exacerbates melanoma immunosuppression by promoting exosome release.Proc Natl Acad Sci U S A202642826135PubTator, text miningPubMed
Investigating the anti-TNBC potential of new quinazoline-based PAK4 inhibitors: design, synthesis and biological evaluation.Eur J Med Chem202642800115PubTator, text miningPubMed
PAK4-targeting PROTAC inhibits bladder cancer cell proliferation.PLoS One202642766568PubTator, text miningPubMed
Computational Identification of New Dual PAK4 and NAMPT Inhibitors.Int J Mol Sci202642737604PubTator, text miningPubMed
PAK4: A vanguard of epithelial vertex remodeling.J Cell Biol202642606375PubTator, text miningPubMed
Thiram inhibits human sperm motility and capacitation by increasing mitochondrial O2 - and reducing PTK and PAK4 activity at environmental concentrations.Transl Androl Urol202642583012PubTator, text miningPubMed
Targeting p21-activated kinase 4: Recent advances in the discovery of PAK4 inhibitors and strategies for isoform selectivity.Eur J Med Chem202642546589PubTator, text miningPubMed
Detergent selection as a determinant of protein melting behavior and drug-target interaction-calling in thermal stability proteomics.bioRxiv202642539280PubTator, text miningPubMed
p21-activated kinase 4 drives hepatic stellate cell activation and liver fibrosis through the phosphorylation of YAP at T428.Signal Transduct Target Ther202642527392PubTator, text miningPubMed
Phosphoproteomic Profiling Identifies PAK4 S474 Phosphorylation Affects Docetaxel Chemosensitivity via Modulation of Microtubule Stabilization in Breast Cancer.Biomedicines202642512103PubTator, text miningPubMed

1 to 10 of 1,639

See all 1,639 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10298

GET https://conductscience.org/api/genes/v1/10298/patents?page=2