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Gene · 1031

CDKN2C: cyclin dependent kinase inhibitor 2C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDKN2C: cyclin dependent kinase inhibitor 2C. Genes, record 1031. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1031

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Gene

Symbol
CDKN2C
HGNC
Name
cyclin dependent kinase inhibitor 2C
HGNC
NCBI Gene ID
1031
NCBI Gene
HGNC ID
HGNC:1789
HGNC
Ensembl
ENSG00000123080
NCBI Gene
Aliases
INK4C, p18, p18-INK4C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42773Cyclin-dependent kinase 4 inhibitor C1686Ensembl, GeneID, HGNC

Source UniProt

Patents82

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192106P42773Espacenet
EP 4641202 A22025-10-294549P42773Espacenet
JP 2025517970 A2025-06-122106P42773Espacenet
KR 1020250017231 A2025-02-044549P42773Espacenet
JP 2024123008 A2024-09-105818P42773Espacenet
JP 2024123008 A2024-09-105819P42773Espacenet
JP 2024123008 A2024-09-105820P42773Espacenet
US 11446398 B22022-09-2021382P42773Espacenet
US 11446398 B22022-09-2021383P42773Espacenet
US 11446398 B22022-09-2021384P42773Espacenet

1 to 10 of 82

See all 82 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,684

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDKN2C papersNewest fiscal year
P30CA016672Cancer Center Support Grant392025
P30CA021765Cancer Center Support Grant (CCSG)272025
P30CA008748Cancer Center Support Grant222025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN212025
P30CA016058Cancer Center Support Grant82025
P30CA016056Roswell Park Cancer Center Support Grant72025
P01CA155258Integrative Oncogenomics of Multiple Myeloma52025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant52025
P30CA046934University of Colorado Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025

1 to 10 of 1,684Source NIH's project files

See all 1,684 nih grants

Papers2,553

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Age-Specific Transcriptomic Signatures for Classification of Progression-Free Survival Outcomes in Luminal A Breast Cancer: An Integrative Machine Learning Approach.Biology (Basel)202642510705PubTator, text miningPubMed
CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16INK4A in Controlling TCR-Dependent and Independent CD8 T Cell Expansion.Eur J Immunol202642345443PubTator, text miningPubMed
Cancer-associated adipocytes confer CDK4/6 inhibitor resistance in ER+ breast cancer through an IL-6/STAT3/SREBF2 axis coupled with cholesterol metabolism and cell cycle reprogramming.Int J Biol Sci202642328452PubTator, text miningPubMed
EBV (LMP1) enhances cisplatin resistance by enhancing degradation of interferon regulatory factor 3.Cell Commun Signal202642141449PubTator, text miningPubMed
Short-Duration HIPEC-Mimetic Mithramycin A Exposure Induces Durable Transcriptional Remodeling Involving Chromatin Regulatory Networks in Colorectal Cancer Models.Int J Mol Sci202642074218PubTator, text miningPubMed
Ubiquitin Ligase RNF149 Promotes Head and Neck Cancer Growth via Downregulation of CDKN2C.Anticancer Res202642049330PubTator, text miningPubMed
CRISPR Screens Reveal Epstein-Barr Virus-activated JunB as a Key Lymphoblastoid B cell Dependency Factor that Represses Cyclin Dependent Kinase Inhibitor P18INK4c.bioRxiv202641959378PubTator, text miningPubMed
Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities.J Biomed Sci202641928257PubTator, text miningPubMed
RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition.Cell Death Dis202641888518PubTator, text miningPubMed
Blastoid Mantle Cell Lymphoma in the Leukemic Phase: Resolving a Morphological Dilemma Through Flow Cytometry.Cureus202641869126PubTator, text miningPubMed

1 to 10 of 2,553

See all 2,553 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1031

GET https://conductscience.org/api/genes/v1/1031/patents?page=2