ConductScience.org, home

Gene · 10312

TCIRG1: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. TCIRG1: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3. Genes, record 10312. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10312

On this page

Gene

Symbol
TCIRG1
HGNC
Name
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
HGNC
NCBI Gene ID
10312
NCBI Gene
HGNC ID
HGNC:11647
HGNC
Ensembl
ENSG00000110719
NCBI Gene
Aliases
ATP6N1C, ATP6V0A3, Atp6i, OC-116, OC-116kDa, OC116, OPTB1, Stv1, TIRC7, Vph1, a3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13488V-type proton ATPase 116 kDa subunit a 38300Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466630Q13488Espacenet
EP 4650780 A22025-11-192508Q13488Espacenet
EP 4641201 A22025-10-292098Q13488Espacenet
JP 2025529142 A2025-09-044628Q13488Espacenet
US 12371689 B22025-07-294628Q13488Espacenet
JP 2025517969 A2025-06-122098Q13488Espacenet
JP 2025517970 A2025-06-122508Q13488Espacenet
JP 2025063200 A2025-04-155Q13488Espacenet
JP 2025038075 A2025-03-1811Q13488Espacenet
US 11446398 B22022-09-2087347Q13488Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,757

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTCIRG1 papersNewest fiscal year
R01DK018381Studies on the structure of basement membranes112025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant72025
R01NS058949Clinical, Genetic, and Cellular Consequences of Mutations In NA,K-ATPase ATP1A362025
P30CA008748Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant42025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA016042Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30CA056036Translational Research in Cancer32025
I01BX002196lntegrin binding proteins and the kidney22025

1 to 10 of 1,757Source NIH's project files

See all 1,757 nih grants

Papers2,533

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Persistent Neonatal Hypocalcemia as an Early Clue to TCIRG1-Related Infantile Osteopetrosis in an Infant of a Diabetic Mother: A Case Report.Cureus202642799233PubTator, text miningPubMed
Active conformations of neuronal Na+, K+-ATPase isoforms and a disease-causing mutant.Nat Commun202642669691PubTator, text miningPubMed
Osteopetrorickets and calcium homeostasis in children with osteopetrosis: an endocrinological single-center study.Front Endocrinol (Lausanne)202642661684PubTator, text miningPubMed
The TRH-TRHR Axis Acts as a Metabolic Checkpoint for Ammonia Tolerance in AML: Therapeutic Targeting via Imiquimod and Itraconazole.Curr Gene Ther202642634546PubTator, text miningPubMed
Proteome-Level Autophagy-Lysosome Remodelling Marks Ageing in Human Dermal Fibroblasts and Nominates Hydroxytyrosol as a Candidate Nutraceutical.Int J Mol Sci202642589464PubTator, text miningPubMed
A Novel Homozygous T-Cell Immune Regulator 1 (TCIRG1) Stop-Gain Variant Causing Malignant Infantile Osteopetrosis.Cureus202642529563PubTator, text miningPubMed
Non-redundant role of the α3 isoform of Na+,K+-ATPase in neuronal excitability and spiking dynamics.Neuroscience202642349539PubTator, text miningPubMed
Machine learning-based integration develops a novel lysosome-related prognostic signature associated with prognosis and immune infiltration landscape in acute myeloid leukemia.Discov Oncol202642334654PubTator, text miningPubMed
A positive feedback loop of HK3-mediated activation of NF-κB modulates glucose metabolism and promotes proliferation and metastasis in glioblastoma.Int J Biol Macromol202642217708PubTator, text miningPubMed
Clinical and Molecular Characterization of TCIRG1-Related Autosomal Recessive Osteopetrosis with Current Therapeutic Approaches.Biomedicines202642193285PubTator, text miningPubMed

1 to 10 of 2,533

See all 2,533 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10312

GET https://conductscience.org/api/genes/v1/10312/patents?page=2