Gene · 10312
TCIRG1: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TCIRG1: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3. Genes, record 10312. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10312
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13488 | V-type proton ATPase 116 kDa subunit a 3 | 830 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents38
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 66630 | Q13488 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2508 | Q13488 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2098 | Q13488 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4628 | Q13488 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4628 | Q13488 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2098 | Q13488 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2508 | Q13488 | Espacenet |
| JP 2025063200 A | 2025-04-15 | 5 | Q13488 | Espacenet |
| JP 2025038075 A | 2025-03-18 | 11 | Q13488 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 87347 | Q13488 | Espacenet |
1 to 10 of 38
See all 38 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,757
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TCIRG1 papers | Newest fiscal year |
|---|---|---|---|
| R01DK018381 | Studies on the structure of basement membranes | 11 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 7 | 2025 |
| R01NS058949 | Clinical, Genetic, and Cellular Consequences of Mutations In NA,K-ATPase ATP1A3 | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 3 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA056036 | Translational Research in Cancer | 3 | 2025 |
| I01BX002196 | lntegrin binding proteins and the kidney | 2 | 2025 |
1 to 10 of 1,757Source NIH's project files
See all 1,757 nih grantsPapers2,533
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Persistent Neonatal Hypocalcemia as an Early Clue to TCIRG1-Related Infantile Osteopetrosis in an Infant of a Diabetic Mother: A Case Report. | Cureus | 2026 | 42799233 | PubTator, text mining | PubMed |
| Active conformations of neuronal Na+, K+-ATPase isoforms and a disease-causing mutant. | Nat Commun | 2026 | 42669691 | PubTator, text mining | PubMed |
| Osteopetrorickets and calcium homeostasis in children with osteopetrosis: an endocrinological single-center study. | Front Endocrinol (Lausanne) | 2026 | 42661684 | PubTator, text mining | PubMed |
| The TRH-TRHR Axis Acts as a Metabolic Checkpoint for Ammonia Tolerance in AML: Therapeutic Targeting via Imiquimod and Itraconazole. | Curr Gene Ther | 2026 | 42634546 | PubTator, text mining | PubMed |
| Proteome-Level Autophagy-Lysosome Remodelling Marks Ageing in Human Dermal Fibroblasts and Nominates Hydroxytyrosol as a Candidate Nutraceutical. | Int J Mol Sci | 2026 | 42589464 | PubTator, text mining | PubMed |
| A Novel Homozygous T-Cell Immune Regulator 1 (TCIRG1) Stop-Gain Variant Causing Malignant Infantile Osteopetrosis. | Cureus | 2026 | 42529563 | PubTator, text mining | PubMed |
| Non-redundant role of the α3 isoform of Na+,K+-ATPase in neuronal excitability and spiking dynamics. | Neuroscience | 2026 | 42349539 | PubTator, text mining | PubMed |
| Machine learning-based integration develops a novel lysosome-related prognostic signature associated with prognosis and immune infiltration landscape in acute myeloid leukemia. | Discov Oncol | 2026 | 42334654 | PubTator, text mining | PubMed |
| A positive feedback loop of HK3-mediated activation of NF-κB modulates glucose metabolism and promotes proliferation and metastasis in glioblastoma. | Int J Biol Macromol | 2026 | 42217708 | PubTator, text mining | PubMed |
| Clinical and Molecular Characterization of TCIRG1-Related Autosomal Recessive Osteopetrosis with Current Therapeutic Approaches. | Biomedicines | 2026 | 42193285 | PubTator, text mining | PubMed |
1 to 10 of 2,533
See all 2,533 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10312
GET https://conductscience.org/api/genes/v1/10312/patents?page=2