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Gene · 10313

RTN3: reticulon 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RTN3: reticulon 3. Genes, record 10313. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10313

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Gene

Symbol
RTN3
HGNC
Name
reticulon 3
HGNC
NCBI Gene ID
10313
NCBI Gene
HGNC ID
HGNC:10469
HGNC
Ensembl
ENSG00000133318
NCBI Gene
Aliases
ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95197Reticulon-31,0321Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461434O95197Espacenet
EP 4641201 A22025-10-2910235O95197Espacenet
JP 2025529142 A2025-09-043792O95197Espacenet
US 12371689 B22025-07-293792O95197Espacenet
JP 2025517969 A2025-06-1210235O95197Espacenet
KR 1020240173306 A2024-12-1111O95197Espacenet
US 11446398 B22022-09-2072783O95197Espacenet
JP 2022524081 A2022-04-27175754O95197Espacenet
US 11078247 B22021-08-039854O95197Espacenet
KR 1020210091089 A2021-07-2128O95197Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants668

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRTN3 papersNewest fiscal year
R01AG046929Inhibition of BACE1 for benefiting Alzheimer's patients52025
R01CA118953Improving Outcomes Assessment in Chronic Graft versus Host Disease52025
P30CA014195Cancer Center Support Grant (CCSG)22025
P30CA068485Cancer Center Support Grant22025
P30DK045735Yale Diabetes Research Center22025
P30EY008126Core Grant in Vision Research22025
R01DE013414MATRIX BASED MINERAL ENAMEL-BIOMIMETICS22025
R35GM131681The diverse roles of ER-Golgi trafficking machinery in autophagy and ER quality control22025
T32HD040686Pediatric Neurointensive Care and Resuscitation Research22025
UL1TR001863Yale Clinical and Translational Science Award22025

1 to 10 of 668Source NIH's project files

See all 668 nih grants

Papers1,763

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Reticulon-3 in endoplasmic reticulum remodeling and cardiometabolic-fibrotic disease.Pharmacol Res202642822554PubTator, text miningPubMed
Multimodal AI and single-cell transcriptomics integrate to construct a histopathological prognostic model for bladder cancer, revealing the RTN3-glycolysis axis in chemoresistance.Exp Hematol Oncol202642745263PubTator, text miningPubMed
Retraction: Tissue specificity and regulation of the N-terminal diversity of reticulon 3.Biochem J202642719941PubTator, text miningPubMed
Shikonin inhibits bladder cancer progression by targeting deoxyribonuclease 2 to suppress reticulon 3-dependent endoplasmic reticulum autophagy.Phytomedicine202642594755PubTator, text miningPubMed
Integrating Mendelian randomization, machine learning and retrospective clinical data: an exploratory analysis of the cross-disease association between CHB and PD, with a focus on eosinophil alterations.
Front Neurol202642494392PubTator, text miningPubMed
Downregulation of miR-6721-5p in the serum of patients with spinal cord injury and its role in regulating microglial inflammation via targeting RTN3.J Orthop Surg Res202642415078PubTator, text miningPubMed
Unveiling ER-Phagy Receptors in Thyroid Cancer: A Combined Approach of Public Data Mining and In Vitro Validation.Clin Med Insights Oncol202642312220PubTator, text miningPubMed
Beyond Free Virions: Interconnected Secretory Pathways and Reticulon 3 (RTN3) Coordinate Extracellular Vesicle Diversity for Infectious Exosome Generation.Biology (Basel)202642117840PubTator, text miningPubMed
An autophagy-related molecule reticulon 3 functions as a novel prognostic biomarker in hepatocellular carcinoma.Genes Dis202642063417PubTator, text miningPubMed
Interactions of Silver Ions with the Hydroxyapatite-Iron Oxide Composite Surface in Liquid.Chemphyschem202642018490PubTator, text miningPubMed

1 to 10 of 1,763

See all 1,763 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10313

GET https://conductscience.org/api/genes/v1/10313/patents?page=2