ConductScience.org, home

Gene · 10392

NOD1: nucleotide binding oligomerization domain containing 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. NOD1: nucleotide binding oligomerization domain containing 1. Genes, record 10392. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10392

On this page

Gene

Symbol
NOD1
HGNC
Name
nucleotide binding oligomerization domain containing 1
HGNC
NCBI Gene ID
10392
NCBI Gene
HGNC ID
HGNC:16390
HGNC
Ensembl
ENSG00000106100
NCBI Gene
Aliases
CARD4, CLR7.1, NLRC1, hNod1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y239Nucleotide-binding oligomerization domain-containing protein 19536Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-29405Q9Y239Espacenet
JP 2025517969 A2025-06-12405Q9Y239Espacenet
JP 2024123008 A2024-09-107471Q9Y239Espacenet
US 11446398 B22022-09-2059035Q9Y239Espacenet
JP 2022524081 A2022-04-27162006Q9Y239Espacenet
KR 1020210107561 A2021-09-014Q9Y239Espacenet
US 11078247 B22021-08-037566Q9Y239Espacenet
US 10918740 B22021-02-169151Q9Y239Espacenet
US 10869935 B22020-12-229151Q9Y239Espacenet
US 10501513 B22019-12-107471Q9Y239Espacenet

1 to 10 of 50

See all 50 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,796

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNOD1 papersNewest fiscal year
P01CA116087H. pylori-induced Inflammation and Gastric Cancer212025
P30DK058404Molecular and Cellular Basis for Digestive Diseases192025
R01CA077955H. Pylori Relationship to Digestive Diseases and Cancer172025
ZIAAI000354Immunoregulatory Defects In Inflammatory Bowel Disease92025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital82025
P30DK034989Yale Liver Center72025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation72025
UL1TR001863Yale Clinical and Translational Science Award62025
ZIAAI000432Regulation Of Immune Responses In Humans and in Experimental Animals62025
R01AI124346Innate immune signaling and stress response52025

1 to 10 of 1,796Source NIH's project files

See all 1,796 nih grants

Papers3,459

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Primary human dermal fibroblasts selectively sense LPS, poly I:C and ADP heptose and initiate immune response mostly through chemokine secretion.Innate Immun202642751893PubTator, text miningPubMed
Whole-Exome Sequencing Identifies Candidate Genomic Features Associated with Response to Platinum-Based Chemotherapy and Ixabepilone-Based Treatment in Ovarian Cancer.Int J Mol Sci202642737428PubTator, text miningPubMed
Expression, Regulation and Therapeutic Implications of Nod-Like Receptors in Endodontics: A Narrative Review.Int Endod J202642677679PubTator, text miningPubMed
Conjugated NOD1-Centered Dual Agonists Exhibit Modest In Vitro Immunomodulation but Potent In Vivo Adjuvanticity.ACS Bio Med Chem Au202642630639PubTator, text miningPubMed
Immunomodulatory effect of Lacticaseibacillus rhamnosus and Lactobacillus acidophilus in human dendritic cells.Arch Microbiol202642573797PubTator, text miningPubMed
Immunogenicity of a Candidate Hepatitis C Vaccine Based on Non-Structural DNA-Protein Sequences and a Novel Complex Adjuvant.Vaccines (Basel)202642506677PubTator, text miningPubMed
Integrative multi-omics and mendelian randomization reveal the critical role of pyroptosis in prognosis and therapy of lung squamous cell carcinomas.Front Cell Dev Biol202642488553PubTator, text miningPubMed
CSN3 promotes gastric cancer progression and is associated with immune infiltration and inflammatory signaling.Transl Cancer Res202642445438PubTator, text miningPubMed
NOD1 is a key mediator of atrial myopathy in heart failure.Theranostics202642370189PubTator, text miningPubMed
AKT-mediated phosphorylation of ZDHHC5 promotes NOD1 palmitoylation and innate immune signaling.Front Immunol202642344932PubTator, text miningPubMed

1 to 10 of 3,459

See all 3,459 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10392

GET https://conductscience.org/api/genes/v1/10392/patents?page=2