Gene · 10395
DLC1: DLC1 Rho GTPase activating protein
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. DLC1: DLC1 Rho GTPase activating protein. Genes, record 10395. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10395
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96QB1 | Rho GTPase-activating protein 7 | 1,528 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents14
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 2964 | Q96QB1 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2535 | Q96QB1 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2535 | Q96QB1 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2964 | Q96QB1 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27261 | Q96QB1 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 27261 | Q96QB1 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 27261 | Q96QB1 | Espacenet |
| JP 2022147356 A | 2022-10-06 | 318 | Q96QB1 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 25002 | Q96QB1 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 127973 | Q96QB1 | Espacenet |
1 to 10 of 14
See all 14 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,004
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DLC1 papers | Newest fiscal year |
|---|---|---|---|
| ZIABC008905 | Tumor gene expression in vitro and in vivo | 10 | 2025 |
| ZIABC010579 | Papillomavirus Virion Proteins and Vaccines | 5 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 4 | 2025 |
| ZIABC011492 | Precision Medicine of Cancer | 4 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
| R35GM136226 | Multiplex Imaging of Signaling Pathways in Cell Motility | 3 | 2025 |
| T32CA009109 | Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies | 3 | 2025 |
| ZIABC006150 | DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs | 3 | 2025 |
| ZIASC010355 | Angiogenesis and Tumor Growth | 3 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 2 | 2025 |
1 to 10 of 1,004Source NIH's project files
See all 1,004 nih grantsPapers1,565
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cytoskeletal disassembly by optogenetic control of RhoA signaling termination. | bioRxiv | 2026 | 42818273 | PubTator, text mining | PubMed |
| Single-blastomere transcriptomics identifies NR5A2-associated metabolic genes during porcine zygotic genome activation. | Theriogenology | 2026 | 42497609 | PubTator, text mining | PubMed |
Non-coding Regulatory Variants in ASD (Autism Spectrum Disorders) Disrupt CTCF Domains and Shape Cell-Type-Specific Neurodevelopmental Landscapes Revealed by Single-Cell Analyses and Cortical Organoids. | Res Sq | 2026 | 42281968 | PubTator, text mining | PubMed |
| Early blood DNA methylation patterns associated with glycemic progression in a prospective Indian cohort. | Clin Epigenetics | 2026 | 41992370 | PubTator, text mining | PubMed |
| GTPase-activating protein DLC1 spatio-temporally regulates Rho signaling. | Elife | 2026 | 41960902 | PubTator, text mining | PubMed |
| Modification of internal RNA domains from the long non-coding RNA XIST refines roles in silencing and heterochromatin recruitment. | Hum Mol Genet | 2026 | 41926242 | PubTator, text mining | PubMed |
| Acute E-Cigarette Aerosol Condensate Exposure Disrupts the Transcriptome and Proteome Profiles of Human Bronchial Epithelial BEAS-2B Cells. | Cells | 2026 | 41892316 | PubTator, text mining | PubMed |
| Chromatin accessibility regulates age-dependent nuclear mechanotransduction. | Proc Natl Acad Sci U S A | 2026 | 41886372 | PubTator, text mining | PubMed |
| Interplay of Interleukin-1β and Curcumin on VEGF Expression in Breast Cancer Cells. | Oncol Res | 2026 | 41799514 | PubTator, text mining | PubMed |
| A bioinformatics approach to identify potential biomarkers of high-grade ovarian cancer. | J Turk Ger Gynecol Assoc | 2026 | 41772983 | PubTator, text mining | PubMed |
1 to 10 of 1,565
See all 1,565 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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