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Gene · 10397

NDRG1: N-myc downstream regulated 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NDRG1: N-myc downstream regulated 1. Genes, record 10397. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10397

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Gene

Symbol
NDRG1
HGNC
Name
N-myc downstream regulated 1
HGNC
NCBI Gene ID
10397
NCBI Gene
HGNC ID
HGNC:7679
HGNC
Ensembl
ENSG00000104419
NCBI Gene
Aliases
CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92597Protein NDRG13941Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455846Q92597Espacenet
JP 2026004568 A2026-01-1455848Q92597Espacenet
EP 4650780 A22025-11-195283Q92597Espacenet
EP 4641201 A22025-10-294869Q92597Espacenet
JP 2025517969 A2025-06-124869Q92597Espacenet
JP 2025517970 A2025-06-125283Q92597Espacenet
JP 2025032204 A2025-03-1132104Q92597Espacenet
JP 2025032204 A2025-03-1132106Q92597Espacenet
EP 4461818 A22024-11-1332104Q92597Espacenet
EP 4461818 A22024-11-1332106Q92597Espacenet

1 to 10 of 52

See all 52 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,937

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNDRG1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant312025
P30CA016087Cancer Center Support Grant162025
P30CA008748Cancer Center Support Grant122025
P30CA006973Regional Oncology Research Center92025
UL1TR001863Yale Clinical and Translational Science Award72025
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)62025
P30CA016056Roswell Park Cancer Center Support Grant52025
U01CA113913Prostate Cancer Biomarker and Imaging Validation Alliance: Emory University, University of Alabama Birmingham, and University of Texas Southwestern52025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes42025
P30CA014520UW Comprehensive Cancer Center Support42025

1 to 10 of 1,937Source NIH's project files

See all 1,937 nih grants

Papers3,293

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The GSEC-encoded polypeptide GESP drives colorectal cancer tumorigenesis via NPM1-c-Myc-mediated repression of NDRG1.Oncogene202642680813PubTator, text miningPubMed
NDRG1 expression in cancers confers dependence on DNA damage repair and sensitivity to quinacrine.Sci Signal202642479816PubTator, text miningPubMed
Spatial and single-cell profiling identify NDRG1⁺ macrophages as key hallmark of angiogenic remodeling and platinum resistance in HGSOC.Transl Oncol202642442223PubTator, text miningPubMed
Machine Learning-Based Identification of Tamoxifen Resistance-Associated Genes and Their Application in Prognostic Modeling of Breast Cancer.J Vis Exp202642441516PubTator, text miningPubMed
Single-cell and bulk transcriptomics identify senescence-related EMT transcriptional programs and a prognostic framework in pancreatic ductal adenocarcinoma.BMC Gastroenterol202642420840PubTator, text miningPubMed
ANGPTL4 contributes to osimertinib resistance through NDRG1-associated extracellular matrix remodeling in EGFR-mutant NSCLC organoid models.Cancer Cell Int202642415069PubTator, text miningPubMed
RIN4 fragments released by AvrRpt2 promote NDR1-dependent activation of RPS2.Plant Cell202642413037PubTator, text miningPubMed
Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle-Mediated Crosstalk in Pancreatic Cancer.J Extracell Vesicles202642377994PubTator, text miningPubMed
Application of single-cell RNA sequencing in preeclampsia.Front Glob Womens Health202642367612PubTator, text miningPubMed
Multiomics Reveals NDRG1-Driven Oral Squamous Cell Carcinoma Progression: Competitive Endogenous RNAs Regulation and Proangiogenic Microenvironment Remodelling.Int Dent J202642364411PubTator, text miningPubMed

1 to 10 of 3,293

See all 3,293 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10397

GET https://conductscience.org/api/genes/v1/10397/patents?page=2