Gene · 10403
NDC80: NDC80 kinetochore complex component
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NDC80: NDC80 kinetochore complex component. Genes, record 10403. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10403
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14777 | Kinetochore protein NDC80 homolog | 642 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents124
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641202 A2 | 2025-10-29 | 4521 | O14777 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4521 | O14777 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 4899 | O14777 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 55546 | O14777 | Espacenet |
| US 11434535 B2 | 2022-09-06 | 43 | O14777 | Espacenet |
| JP 2022077016 A | 2022-05-20 | 26 | O14777 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 158517 | O14777 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 7326 | O14777 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 4899 | O14777 | Espacenet |
| EP 3403091 A1 | 2018-11-21 | 643 | O14777 | Espacenet |
1 to 10 of 124
See all 124 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,213
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NDC80 papers | Newest fiscal year |
|---|---|---|---|
| R01GM074215 | Kinetochore Specification and Function | 20 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 10 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 9 | 2025 |
| R35GM130365 | Mechanisms of Kinetochore-Microtubule Attachment and Regulation | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 8 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 7 | 2025 |
| P50CA058223 | SPORE in Breast Cancer | 7 | 2025 |
| U19AG063911 | ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2) | 7 | 2025 |
| P30AG062421 | Massachusetts Alzheimer's Disease Research Center (MADRC) | 6 | 2025 |
1 to 10 of 1,213Source NIH's project files
See all 1,213 nih grantsPapers2,370
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Rewiring of Molecular Networks Induced by the Combination of Loratadine, Raloxifene, and Sorafenib Leads to the Identification of Clinically Relevant Therapeutic Targets in Hepatocellular Carcinoma. | Biomedicines | 2026 | 42792641 | PubTator, text mining | PubMed |
| Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80-Nuf2 Interaction for Hepatocellular Carcinoma Therapy. | J Med Chem | 2026 | 42720478 | PubTator, text mining | PubMed |
| Targeting the HEC1-NEK2 Axis Suppresses DLBCL Progression and Overcomes Vincristine Resistance. | Mol Cancer Ther | 2026 | 42708803 | PubTator, text mining | PubMed |
| Identification of a cholesterol metabolism-related signature based on KIF20A and NDC80 for prognostic stratification and immunotherapy prediction in hepatocellular carcinoma. | Cancer Biomark | 2026 | 42685023 | PubTator, text mining | PubMed |
| Mammalian metaphase kinetochores are elastic and require condensin for robust structure and function. | J Cell Biol | 2026 | 42640254 | PubTator, text mining | PubMed |
| Structural and Functional Insights Into (S)-5'-C-Guanidinopropyl Uridine-Modified Oligonucleotides With 2'-O-Methyl and 2'-Fluoro Substitutions for RNAi Therapeutics. | ChemMedChem | 2026 | 42568144 | PubTator, text mining | PubMed |
| Structure and function of the outer kinetochore. | Nat Rev Mol Cell Biol | 2026 | 42547646 | PubTator, text mining | PubMed |
| 1'-Sugar-Tethered Cholesterol-Modified siRNAs with Variable Linker Lengths for Carrier-Free Delivery and Enhanced RNAi Efficiency. | ACS Omega | 2026 | 42518471 | PubTator, text mining | PubMed |
| CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights. | PLoS One | 2026 | 42479720 | PubTator, text mining | PubMed |
| The kinetochore proteins Ndc80 and Dsn1 are required for survival of postmitotic neurons. | bioRxiv | 2026 | 42427708 | PubTator, text mining | PubMed |
1 to 10 of 2,370
See all 2,370 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10403
GET https://conductscience.org/api/genes/v1/10403/patents?page=2