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Gene · 10403

NDC80: NDC80 kinetochore complex component

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NDC80: NDC80 kinetochore complex component. Genes, record 10403. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10403

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Gene

Symbol
NDC80
HGNC
Name
NDC80 kinetochore complex component
HGNC
NCBI Gene ID
10403
NCBI Gene
HGNC ID
HGNC:16909
HGNC
Ensembl
ENSG00000080986
NCBI Gene
Aliases
HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14777Kinetochore protein NDC80 homolog6425Ensembl, GeneID, HGNC

Source UniProt

Patents124

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641202 A22025-10-294521O14777Espacenet
KR 1020250017231 A2025-02-044521O14777Espacenet
US 11564998 B22023-01-314899O14777Espacenet
US 11446398 B22022-09-2055546O14777Espacenet
US 11434535 B22022-09-0643O14777Espacenet
JP 2022077016 A2022-05-2026O14777Espacenet
JP 2022524081 A2022-04-27158517O14777Espacenet
US 11078247 B22021-08-037326O14777Espacenet
US 10463751 B22019-11-054899O14777Espacenet
EP 3403091 A12018-11-21643O14777Espacenet

1 to 10 of 124

See all 124 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,213

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNDC80 papersNewest fiscal year
R01GM074215Kinetochore Specification and Function202025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions102025
P30CA016086Cancer Center Support Grant92025
R35GM130365Mechanisms of Kinetochore-Microtubule Attachment and Regulation92025
P30CA008748Cancer Center Support Grant82025
P30CA015704Cancer Center Support Grant82025
P30CA023108Cancer Center Support Grant72025
P50CA058223SPORE in Breast Cancer72025
U19AG063911ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2)72025
P30AG062421Massachusetts Alzheimer's Disease Research Center (MADRC)62025

1 to 10 of 1,213Source NIH's project files

See all 1,213 nih grants

Papers2,370

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Rewiring of Molecular Networks Induced by the Combination of Loratadine, Raloxifene, and Sorafenib Leads to the Identification of Clinically Relevant Therapeutic Targets in Hepatocellular Carcinoma.Biomedicines202642792641PubTator, text miningPubMed
Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80-Nuf2 Interaction for Hepatocellular Carcinoma Therapy.J Med Chem202642720478PubTator, text miningPubMed
Targeting the HEC1-NEK2 Axis Suppresses DLBCL Progression and Overcomes Vincristine Resistance.Mol Cancer Ther202642708803PubTator, text miningPubMed
Identification of a cholesterol metabolism-related signature based on KIF20A and NDC80 for prognostic stratification and immunotherapy prediction in hepatocellular carcinoma.Cancer Biomark202642685023PubTator, text miningPubMed
Mammalian metaphase kinetochores are elastic and require condensin for robust structure and function.J Cell Biol202642640254PubTator, text miningPubMed
Structural and Functional Insights Into (S)-5'-C-Guanidinopropyl Uridine-Modified Oligonucleotides With 2'-O-Methyl and 2'-Fluoro Substitutions for RNAi Therapeutics.ChemMedChem202642568144PubTator, text miningPubMed
Structure and function of the outer kinetochore.Nat Rev Mol Cell Biol202642547646PubTator, text miningPubMed
1'-Sugar-Tethered Cholesterol-Modified siRNAs with Variable Linker Lengths for Carrier-Free Delivery and Enhanced RNAi Efficiency.ACS Omega202642518471PubTator, text miningPubMed
CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights.PLoS One202642479720PubTator, text miningPubMed
The kinetochore proteins Ndc80 and Dsn1 are required for survival of postmitotic neurons.bioRxiv202642427708PubTator, text miningPubMed

1 to 10 of 2,370

See all 2,370 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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