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Gene · 10406

WFDC2: WAP four-disulfide core domain 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. WFDC2: WAP four-disulfide core domain 2. Genes, record 10406. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10406

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Gene

Symbol
WFDC2
HGNC
Name
WAP four-disulfide core domain 2
HGNC
NCBI Gene ID
10406
NCBI Gene
HGNC ID
HGNC:15939
HGNC
Ensembl
ENSG00000101443
NCBI Gene
Aliases
BENP, EDDM4, HE4, WAP5, dJ461P17.6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14508WAP four-disulfide core domain protein 21240Ensembl, GeneID, HGNC

Source UniProt

Patents132

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026000906 A2026-01-06271Q14508Espacenet
EP 4650780 A22025-11-199150Q14508Espacenet
JP 2025147176 A2025-10-0614236Q14508Espacenet
JP 2025138725 A2025-09-252434Q14508Espacenet
JP 2025529142 A2025-09-048066Q14508Espacenet
US 12371689 B22025-07-298066Q14508Espacenet
JP 2025517970 A2025-06-129150Q14508Espacenet
JP 2025028160 A2025-02-2814236Q14508Espacenet
EP 4500184 A12025-02-052Q14508Espacenet
KR 1020250010750 A2025-01-2114236Q14508Espacenet

1 to 10 of 132

See all 132 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants920

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleWFDC2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant322025
U01CA200462MD Anderson Cancer Center EDRN- Clinical Validation Center for Early Detection of Ovarian Cancer with a multiple marker algorithm162025
P30DK058404Molecular and Cellular Basis for Digestive Diseases142025
I01BX000930Oxyntic Atrophy and Novel Gastric Lineages.132025
P30CA008748Cancer Center Support Grant112025
U01CA152637Fred Hutchinson Breast Cancer Clinical Validation Center112025
R01DK101332Induction and Evolution of Metaplasia in the Stomach102025
P30CA047904Cancer Center Support Grant62025
P30CA068485Cancer Center Support Grant62025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer62025

1 to 10 of 920Source NIH's project files

See all 920 nih grants

Papers3,333

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Development of a europium-thiosemicarbazide-based nano-optical biosensor for early detection of HE4 in ovarian cancer.Spectrochim Acta A Mol Biomol Spectrosc202742810034PubTator, text miningPubMed
Trimetallic CoFeZn nanozymes with enhanced peroxidase-mimetic activity for ultrasensitive electrochemical immunosensing of HE4: Toward ovarian cancer monitoring.Talanta202742475949PubTator, text miningPubMed
Microfluidic biosensors for early detection of ovarian cancer.Clin Chim Acta202742288273PubTator, text miningPubMed
Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality.Aging Cell202642823846PubTator, text miningPubMed
Platelet activation and eicosanoid signaling in ovarian cancer: implications for biomarker development.Mol Biol Rep202642821018PubTator, text miningPubMed
Plasma Proteomic Signatures for Early Risk Stratification Across Cardiovascular-Kidney-Metabolic Stages 0-2.Diabetes Obes Metab202642816446PubTator, text miningPubMed
Spontaneous rupture of a mucinous borderline ovarian tumour in late pregnancy: a case report.Front Oncol202642812587PubTator, text miningPubMed
Diagnostic Value of Serum HE4, TFF3, and CA72-4 for Gastric Cancer Stratified by Helicobacter pylori Infection Status.Br J Hosp Med (Lond)202642812095PubTator, text miningPubMed
Clinical and Ultrasound Characteristics of High-Grade Endometrial Stromal Sarcoma.J Clin Ultrasound202642811502PubTator, text miningPubMed
[Predictive value of a combined prediction model for pathologic upgrade to endometrial carcinoma after hysterectomy in patients with endometrial hyperplasia].Zhonghua Fu Chan Ke Za Zhi202642802112PubTator, text miningPubMed

1 to 10 of 3,333

See all 3,333 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10406

GET https://conductscience.org/api/genes/v1/10406/patents?page=2