Gene · 10406
WFDC2: WAP four-disulfide core domain 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. WFDC2: WAP four-disulfide core domain 2. Genes, record 10406. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10406
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14508 | WAP four-disulfide core domain protein 2 | 124 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents132
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026000906 A | 2026-01-06 | 271 | Q14508 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9150 | Q14508 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 14236 | Q14508 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 2434 | Q14508 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 8066 | Q14508 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 8066 | Q14508 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9150 | Q14508 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 14236 | Q14508 | Espacenet |
| EP 4500184 A1 | 2025-02-05 | 2 | Q14508 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 14236 | Q14508 | Espacenet |
1 to 10 of 132
See all 132 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants920
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | WFDC2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 32 | 2025 |
| U01CA200462 | MD Anderson Cancer Center EDRN- Clinical Validation Center for Early Detection of Ovarian Cancer with a multiple marker algorithm | 16 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 14 | 2025 |
| I01BX000930 | Oxyntic Atrophy and Novel Gastric Lineages. | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| U01CA152637 | Fred Hutchinson Breast Cancer Clinical Validation Center | 11 | 2025 |
| R01DK101332 | Induction and Evolution of Metaplasia in the Stomach | 10 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 6 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| P50CA136393 | Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer | 6 | 2025 |
1 to 10 of 920Source NIH's project files
See all 920 nih grantsPapers3,333
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Development of a europium-thiosemicarbazide-based nano-optical biosensor for early detection of HE4 in ovarian cancer. | Spectrochim Acta A Mol Biomol Spectrosc | 2027 | 42810034 | PubTator, text mining | PubMed |
| Trimetallic CoFeZn nanozymes with enhanced peroxidase-mimetic activity for ultrasensitive electrochemical immunosensing of HE4: Toward ovarian cancer monitoring. | Talanta | 2027 | 42475949 | PubTator, text mining | PubMed |
| Microfluidic biosensors for early detection of ovarian cancer. | Clin Chim Acta | 2027 | 42288273 | PubTator, text mining | PubMed |
| Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality. | Aging Cell | 2026 | 42823846 | PubTator, text mining | PubMed |
| Platelet activation and eicosanoid signaling in ovarian cancer: implications for biomarker development. | Mol Biol Rep | 2026 | 42821018 | PubTator, text mining | PubMed |
| Plasma Proteomic Signatures for Early Risk Stratification Across Cardiovascular-Kidney-Metabolic Stages 0-2. | Diabetes Obes Metab | 2026 | 42816446 | PubTator, text mining | PubMed |
| Spontaneous rupture of a mucinous borderline ovarian tumour in late pregnancy: a case report. | Front Oncol | 2026 | 42812587 | PubTator, text mining | PubMed |
| Diagnostic Value of Serum HE4, TFF3, and CA72-4 for Gastric Cancer Stratified by Helicobacter pylori Infection Status. | Br J Hosp Med (Lond) | 2026 | 42812095 | PubTator, text mining | PubMed |
| Clinical and Ultrasound Characteristics of High-Grade Endometrial Stromal Sarcoma. | J Clin Ultrasound | 2026 | 42811502 | PubTator, text mining | PubMed |
| [Predictive value of a combined prediction model for pathologic upgrade to endometrial carcinoma after hysterectomy in patients with endometrial hyperplasia]. | Zhonghua Fu Chan Ke Za Zhi | 2026 | 42802112 | PubTator, text mining | PubMed |
1 to 10 of 3,333
See all 3,333 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10406
GET https://conductscience.org/api/genes/v1/10406/patents?page=2