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RAPGEF3: Rap guanine nucleotide exchange factor 3
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Gene · 10411

Papers2,768

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,768

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TitleJournalYearPMIDFound bySource
Molecular mechanisms of lipid sensing in human cholecystokinin-secreting enteroendocrine cells.Mol Metab202642805486PubTator, text miningPubMed
"Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation." K. Jankowski, S.E. Lemay, D. Lozano-Ojalvo, et al. Eur Respir J 2025; 66: 2402250.Eur Respir J202642790898PubTator, text miningPubMed
Soluble adenylyl cyclase regulates tight junctions of human intestinal epithelial cells via claudin-4.Am J Physiol Gastrointest Liver Physiol202642691479PubTator, text miningPubMed
The EPAC inhibitor ESI-09 attenuates NF-κB signalling in vascular cells.Biochim Biophys Acta Mol Cell Res202642562185PubTator, text miningPubMed
Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis.World J Otorhinolaryngol Head Neck Surg202642500098PubTator, text miningPubMed
AARS1-catalyzed H4K12 lactylation promotes HCC resistance to targeted therapy by activating RAPGEF3-RAP1 signaling.Cell Death Dis202642481450PubTator, text miningPubMed
cAMP-Activated EPAC Signaling Is an Integral Component of Cardiac Pacemaker Cell Automaticity.Circ Arrhythm Electrophysiol202642345089PubTator, text miningPubMed
Restoring leptin sensitivity in metabolic and extra-metabolic leptin resistance: Pharmacologic strategies, systemic implications, and future directions.EXCLI J202642318499PubTator, text miningPubMed
Adrenergic receptors on immune cells in cardiovascular disease: signaling plasticity, biased agonism, and therapeutic opportunities.Front Physiol202642222281PubTator, text miningPubMed
Novel developments in untangling the significance of Epac signaling in the kidney.Curr Opin Nephrol Hypertens202642130242PubTator, text miningPubMed
A Ponatinib-Associated Transcriptomic Signature: Implications for Cardiovascular Toxicity.Int J Mol Sci202642123636PubTator, text miningPubMed
Preliminary Evaluation of Leuprorelin Acetate Microspheres Plus Levonorgestrel-Releasing Intrauterine System in Endometriosis: An Exploratory Study Focusing on BNIP3 and EPAC1 Expression.J Obstet Gynaecol Res202642120175PubTator, text miningPubMed
Cyclic adenosine monophosphate signaling pathway in tumor-associated macrophages: molecular mechanisms and tumor immunotherapy.Carcinogenesis202642093103PubTator, text miningPubMed
Decoding GPCR signaling reprogramming in cancer: molecular mechanisms and therapeutic implications.Mol Med202642092773PubTator, text miningPubMed
"EPAC1: Molecular architecture, physiological regulation, and therapeutic implications in diseases".Int J Biochem Cell Biol202641966519PubTator, text miningPubMed
A NOD2-Encoded Toggle Switch Resolves the Host-Microbe Battle Over Cyclic AMP Control.bioRxiv202641959225PubTator, text miningPubMed
Preventive Effect of Caffeic Acid Phenethyl Ester, an Active Component of Propolis, against TNF-α-Induced Endothelial Dysfunction through the β2-Adrenoceptor-Mediated eNOS/NO Signal Pathway.J Agric Food Chem202641957988PubTator, text miningPubMed
The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets.Cells202641892342PubTator, text miningPubMed
Harnessing oncogenic signaling to enhance oncolytic virotherapy: Lessons from EPAC-encoding vaccinia virus.Mol Ther Oncol202641853563PubTator, text miningPubMed
Development and Evaluation of Benzofuran Oxoacetic Acid Compounds as EPAC1 Activators.J Med Chem202641826280PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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