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Gene · 10411

RAPGEF3: Rap guanine nucleotide exchange factor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RAPGEF3: Rap guanine nucleotide exchange factor 3. Genes, record 10411. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10411

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Gene

Symbol
RAPGEF3
HGNC
Name
Rap guanine nucleotide exchange factor 3
HGNC
NCBI Gene ID
10411
NCBI Gene
HGNC ID
HGNC:16629
HGNC
Ensembl
ENSG00000079337
NCBI Gene
Aliases
CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910, cAMP-GEFI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95398Rap guanine nucleotide exchange factor 39231Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-291632O95398Espacenet
EP 4641201 A22025-10-2911062O95398Espacenet
JP 2025519096 A2025-06-241632O95398Espacenet
JP 2025517969 A2025-06-1211062O95398Espacenet
JP 2025032204 A2025-03-1134572O95398Espacenet
JP 2025032204 A2025-03-1134575O95398Espacenet
EP 4461818 A22024-11-1334572O95398Espacenet
EP 4461818 A22024-11-1334575O95398Espacenet
JP 2023123507 A2023-09-0570O95398Espacenet
JP 2023058610 A2023-04-2534572O95398Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,977

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRAPGEF3 papersNewest fiscal year
R01DK073368Mechanisms of Compartmentalized cAMP Signaling232025
P30EY004068Core Grant for Vision Research152025
P30DK020572Michigan Diabetes Research Center (MDRC)132025
P30CA016672Cancer Center Support Grant122025
R35CA197622Live-cell Activity Architecture in Cancer102025
P30CA008748Cancer Center Support Grant72025
ZIAMH002386Chemical Coding of Neurotransmission72025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology52025
R01DK080834Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea52025
R01HL058506G Protein-Coupled Receptor Regulation in Airway Myocytes52025

1 to 10 of 1,977Source NIH's project files

See all 1,977 nih grants

Papers2,768

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular mechanisms of lipid sensing in human cholecystokinin-secreting enteroendocrine cells.Mol Metab202642805486PubTator, text miningPubMed
"Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation." K. Jankowski, S.E. Lemay, D. Lozano-Ojalvo, et al. Eur Respir J 2025; 66: 2402250.Eur Respir J202642790898PubTator, text miningPubMed
Soluble adenylyl cyclase regulates tight junctions of human intestinal epithelial cells via claudin-4.Am J Physiol Gastrointest Liver Physiol202642691479PubTator, text miningPubMed
The EPAC inhibitor ESI-09 attenuates NF-κB signalling in vascular cells.Biochim Biophys Acta Mol Cell Res202642562185PubTator, text miningPubMed
Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis.World J Otorhinolaryngol Head Neck Surg202642500098PubTator, text miningPubMed
AARS1-catalyzed H4K12 lactylation promotes HCC resistance to targeted therapy by activating RAPGEF3-RAP1 signaling.Cell Death Dis202642481450PubTator, text miningPubMed
cAMP-Activated EPAC Signaling Is an Integral Component of Cardiac Pacemaker Cell Automaticity.Circ Arrhythm Electrophysiol202642345089PubTator, text miningPubMed
Restoring leptin sensitivity in metabolic and extra-metabolic leptin resistance: Pharmacologic strategies, systemic implications, and future directions.EXCLI J202642318499PubTator, text miningPubMed
Adrenergic receptors on immune cells in cardiovascular disease: signaling plasticity, biased agonism, and therapeutic opportunities.Front Physiol202642222281PubTator, text miningPubMed
Novel developments in untangling the significance of Epac signaling in the kidney.Curr Opin Nephrol Hypertens202642130242PubTator, text miningPubMed

1 to 10 of 2,768

See all 2,768 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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