Gene · 10411
RAPGEF3: Rap guanine nucleotide exchange factor 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RAPGEF3: Rap guanine nucleotide exchange factor 3. Genes, record 10411. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10411
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95398 | Rap guanine nucleotide exchange factor 3 | 923 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4640849 A2 | 2025-10-29 | 1632 | O95398 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11062 | O95398 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1632 | O95398 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11062 | O95398 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34572 | O95398 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34575 | O95398 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 34572 | O95398 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 34575 | O95398 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 70 | O95398 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 34572 | O95398 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,977
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RAPGEF3 papers | Newest fiscal year |
|---|---|---|---|
| R01DK073368 | Mechanisms of Compartmentalized cAMP Signaling | 23 | 2025 |
| P30EY004068 | Core Grant for Vision Research | 15 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 12 | 2025 |
| R35CA197622 | Live-cell Activity Architecture in Cancer | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| ZIAMH002386 | Chemical Coding of Neurotransmission | 7 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 5 | 2025 |
| R01DK080834 | Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea | 5 | 2025 |
| R01HL058506 | G Protein-Coupled Receptor Regulation in Airway Myocytes | 5 | 2025 |
1 to 10 of 1,977Source NIH's project files
See all 1,977 nih grantsPapers2,768
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Molecular mechanisms of lipid sensing in human cholecystokinin-secreting enteroendocrine cells. | Mol Metab | 2026 | 42805486 | PubTator, text mining | PubMed |
| "Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation." K. Jankowski, S.E. Lemay, D. Lozano-Ojalvo, et al. Eur Respir J 2025; 66: 2402250. | Eur Respir J | 2026 | 42790898 | PubTator, text mining | PubMed |
| Soluble adenylyl cyclase regulates tight junctions of human intestinal epithelial cells via claudin-4. | Am J Physiol Gastrointest Liver Physiol | 2026 | 42691479 | PubTator, text mining | PubMed |
| The EPAC inhibitor ESI-09 attenuates NF-κB signalling in vascular cells. | Biochim Biophys Acta Mol Cell Res | 2026 | 42562185 | PubTator, text mining | PubMed |
| Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis. | World J Otorhinolaryngol Head Neck Surg | 2026 | 42500098 | PubTator, text mining | PubMed |
| AARS1-catalyzed H4K12 lactylation promotes HCC resistance to targeted therapy by activating RAPGEF3-RAP1 signaling. | Cell Death Dis | 2026 | 42481450 | PubTator, text mining | PubMed |
| cAMP-Activated EPAC Signaling Is an Integral Component of Cardiac Pacemaker Cell Automaticity. | Circ Arrhythm Electrophysiol | 2026 | 42345089 | PubTator, text mining | PubMed |
| Restoring leptin sensitivity in metabolic and extra-metabolic leptin resistance: Pharmacologic strategies, systemic implications, and future directions. | EXCLI J | 2026 | 42318499 | PubTator, text mining | PubMed |
| Adrenergic receptors on immune cells in cardiovascular disease: signaling plasticity, biased agonism, and therapeutic opportunities. | Front Physiol | 2026 | 42222281 | PubTator, text mining | PubMed |
| Novel developments in untangling the significance of Epac signaling in the kidney. | Curr Opin Nephrol Hypertens | 2026 | 42130242 | PubTator, text mining | PubMed |
1 to 10 of 2,768
See all 2,768 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10411
GET https://conductscience.org/api/genes/v1/10411/patents?page=2