Gene · 10419
PRMT5: protein arginine methyltransferase 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PRMT5: protein arginine methyltransferase 5. Genes, record 10419. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10419
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14744 | Protein arginine N-methyltransferase 5 | 637 | 92 | Ensembl, GeneID, HGNC |
Source UniProt
Patents97
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641202 A2 | 2025-10-29 | 4925 | O14744 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4925 | O14744 | Espacenet |
| EP 4219465 A2 | 2023-08-02 | 1 | O14744 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5473 | O14744 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 68022 | O14744 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 170993 | O14744 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 5473 | O14744 | Espacenet |
| KR 1020190109573 A | 2019-09-25 | 1 | O14744 | Espacenet |
| US 10391089 B2 | 2019-08-27 | 1 | O14744 | Espacenet |
| EP 3498701 A1 | 2019-06-19 | 1 | O14744 | Espacenet |
1 to 10 of 97
See all 97 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| PEMRAMETOSTAT | CHEMBL4466233 | Protein arginine N-methyltransferase 5 inhibitor | INHIBITOR |
Source ChEMBL
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04676516 | PEMRAMETOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT03614728 | PEMRAMETOSTAT | PHASE1/PHASE2 | 2023-02-06 | ClinicalTrials.gov |
| NCT02783300 | PEMRAMETOSTAT | PHASE1 | 2025-03-10 | ClinicalTrials.gov |
NIH grants1,916
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PRMT5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 35 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 29 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 19 | 2025 |
| P30CA023168 | Cancer Center Support Grant | 15 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 9 | 2025 |
| R01CA073764 | FEN1-mediated Okazaki fragment maturation and its deficiency in cancer | 7 | 2025 |
| R01CA166835 | Targeted therapy for t(8;21)+ AML | 7 | 2025 |
| R01HL128239 | Genetic and molecular basis for SRSF2 mutations in myelodysplasia | 7 | 2025 |
| P01CA100730 | Retrovirus Models of Cancer | 6 | 2025 |
| P20GM130457 | COBRE in Digestive and Liver Disease | 6 | 2025 |
1 to 10 of 1,916Source NIH's project files
See all 1,916 nih grantsPapers3,714
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| PRMT5 promotes ferroptosis in cisplatin-induced acute kidney injury through WDR5/ACSL4 pathway. | Redox Biol | 2026 | 42826479 | PubTator, text mining | PubMed |
| Biphasic SMN condensates safeguard stress-induced cytoplasmic mislocalization of splicing RNPs. | Cell Mol Life Sci | 2026 | 42814109 | PubTator, text mining | PubMed |
| Glycolytic reprogramming and cell-specific lactylation in asthma: an evidence-graded framework for testable metabolic-epigenetic profiles. | Front Immunol | 2026 | 42813062 | PubTator, text mining | PubMed |
| Analyzing the cytotoxicity and pro-tumorigenic role of acetyl tributyl citrate in prostate through network toxicology and the immune microenvironment. | Front Immunol | 2026 | 42807872 | PubTator, text mining | PubMed |
| Targeting the untargeted: Emerging targeted therapies in metastatic melanoma beyond BRAF/MEK inhibitors. | Crit Rev Oncol Hematol | 2026 | 42805360 | PubTator, text mining | PubMed |
| NRF2-Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities. | Asia Pac J Clin Oncol | 2026 | 42802387 | PubTator, text mining | PubMed |
| Advances in KRAS-Targeted Therapies for Pancreatic Cancer. | Cancers (Basel) | 2026 | 42794928 | PubTator, text mining | PubMed |
| Synthetic lethality in cancer: mechanisms, therapeutic exploitation and clinical translation. | Signal Transduct Target Ther | 2026 | 42778539 | PubTator, text mining | PubMed |
| Immunohistochemistry Resolves Indeterminate MTAP Deletion Calls From Exome Sequencing: A Pan-Cancer Concordance Study. | Mod Pathol | 2026 | 42778110 | PubTator, text mining | PubMed |
| Epigenetic deregulation in adult gliomas: A key driver of molecular heterogeneity and precision oncology. | J Neuropathol Exp Neurol | 2026 | 42762469 | PubTator, text mining | PubMed |
1 to 10 of 3,714
See all 3,714 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10419
GET https://conductscience.org/api/genes/v1/10419/patents?page=2