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Gene · 10419

PRMT5: protein arginine methyltransferase 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRMT5: protein arginine methyltransferase 5. Genes, record 10419. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10419

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Gene

Symbol
PRMT5
HGNC
Name
protein arginine methyltransferase 5
HGNC
NCBI Gene ID
10419
NCBI Gene
HGNC ID
HGNC:10894
HGNC
Ensembl
ENSG00000100462
NCBI Gene
Aliases
HRMT1L5, HSL7, IBP72, JBP1, SKB1, SKB1Hs
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14744Protein arginine N-methyltransferase 563792Ensembl, GeneID, HGNC

Source UniProt

Patents97

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641202 A22025-10-294925O14744Espacenet
KR 1020250017231 A2025-02-044925O14744Espacenet
EP 4219465 A22023-08-021O14744Espacenet
US 11564998 B22023-01-315473O14744Espacenet
US 11446398 B22022-09-2068022O14744Espacenet
JP 2022524081 A2022-04-27170993O14744Espacenet
US 10463751 B22019-11-055473O14744Espacenet
KR 1020190109573 A2019-09-251O14744Espacenet
US 10391089 B22019-08-271O14744Espacenet
EP 3498701 A12019-06-191O14744Espacenet

1 to 10 of 97

See all 97 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
PEMRAMETOSTATCHEMBL4466233Protein arginine N-methyltransferase 5 inhibitorINHIBITOR

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04676516PEMRAMETOSTATPHASE2ClinicalTrials.gov
NCT03614728PEMRAMETOSTATPHASE1/PHASE22023-02-06ClinicalTrials.gov
NCT02783300PEMRAMETOSTATPHASE12025-03-10ClinicalTrials.gov

NIH grants1,916

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRMT5 papersNewest fiscal year
P30CA008748Cancer Center Support Grant352025
P30CA016672Cancer Center Support Grant292025
P30CA016058Cancer Center Support Grant192025
P30CA023168Cancer Center Support Grant152025
P30CA013330Cancer Center Support Grant92025
R01CA073764FEN1-mediated Okazaki fragment maturation and its deficiency in cancer72025
R01CA166835Targeted therapy for t(8;21)+ AML72025
R01HL128239Genetic and molecular basis for SRSF2 mutations in myelodysplasia72025
P01CA100730Retrovirus Models of Cancer62025
P20GM130457COBRE in Digestive and Liver Disease62025

1 to 10 of 1,916Source NIH's project files

See all 1,916 nih grants

Papers3,714

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PRMT5 promotes ferroptosis in cisplatin-induced acute kidney injury through WDR5/ACSL4 pathway.Redox Biol202642826479PubTator, text miningPubMed
Biphasic SMN condensates safeguard stress-induced cytoplasmic mislocalization of splicing RNPs.Cell Mol Life Sci202642814109PubTator, text miningPubMed
Glycolytic reprogramming and cell-specific lactylation in asthma: an evidence-graded framework for testable metabolic-epigenetic profiles.Front Immunol202642813062PubTator, text miningPubMed
Analyzing the cytotoxicity and pro-tumorigenic role of acetyl tributyl citrate in prostate through network toxicology and the immune microenvironment.Front Immunol202642807872PubTator, text miningPubMed
Targeting the untargeted: Emerging targeted therapies in metastatic melanoma beyond BRAF/MEK inhibitors.Crit Rev Oncol Hematol202642805360PubTator, text miningPubMed
NRF2-Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities.Asia Pac J Clin Oncol202642802387PubTator, text miningPubMed
Advances in KRAS-Targeted Therapies for Pancreatic Cancer.Cancers (Basel)202642794928PubTator, text miningPubMed
Synthetic lethality in cancer: mechanisms, therapeutic exploitation and clinical translation.Signal Transduct Target Ther202642778539PubTator, text miningPubMed
Immunohistochemistry Resolves Indeterminate MTAP Deletion Calls From Exome Sequencing: A Pan-Cancer Concordance Study.Mod Pathol202642778110PubTator, text miningPubMed
Epigenetic deregulation in adult gliomas: A key driver of molecular heterogeneity and precision oncology.J Neuropathol Exp Neurol202642762469PubTator, text miningPubMed

1 to 10 of 3,714

See all 3,714 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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