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Gene · 10452

TOMM40: translocase of outer mitochondrial membrane 40

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TOMM40: translocase of outer mitochondrial membrane 40. Genes, record 10452. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10452

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Gene

Symbol
TOMM40
HGNC
Name
translocase of outer mitochondrial membrane 40
HGNC
NCBI Gene ID
10452
NCBI Gene
HGNC ID
HGNC:18001
HGNC
Ensembl
ENSG00000130204
NCBI Gene
Aliases
C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O96008Mitochondrial import receptor subunit TOM40 homolog36112Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467713O96008Espacenet
JP 2026004568 A2026-01-1467714O96008Espacenet
JP 2026004568 A2026-01-1467715O96008Espacenet
EP 4650780 A22025-11-191389O96008Espacenet
EP 4640849 A22025-10-29164O96008Espacenet
EP 4641201 A22025-10-291024O96008Espacenet
EP 4641202 A22025-10-294457O96008Espacenet
JP 2025519096 A2025-06-24164O96008Espacenet
JP 2025517969 A2025-06-121024O96008Espacenet
JP 2025517970 A2025-06-121389O96008Espacenet

1 to 10 of 52

See all 52 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,318

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTOMM40 papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)532025
P30DK063491Diabetes Research Center (DRC)182025
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)142025
R01NS017950Precursors of Stroke Incidence and Prognosis122025
U01AG009740Health and Retirement Study: Yrs 35-40122025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions102025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal102025
U24AG041689THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE102025
P30AG034424Center for Population Health and Aging92025
P30AG066444Alzheimer's Disease Research Center92025

1 to 10 of 2,318Source NIH's project files

See all 2,318 nih grants

Papers2,093

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The DDIT4L-TOM40-ATP5A pathway suppresses glioblastoma oncogenesis.Genes Dis202742733534PubTator, text miningPubMed
Alzheimer's Disease DNA Methylation Index (AD-DMI) and its Association with Late-Life Cognitive Function.NPJ Dement202642583477PubTator, text miningPubMed
New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics202642535978PubTator, text miningPubMed
Targeting TOMM40 unleashes immunogenic mitophagy to facilitate antigen presentation and immunotherapy sensitization.J Immunother Cancer202642508829PubTator, text miningPubMed
TOMM40/FADS2 Expression Ratio Predicts the Sensitivity to mTOR Inhibitors in Triple-Negative Breast Cancer.Cancer Med202642470318PubTator, text miningPubMed
HPD is a copper-binding protein that interacts with DLAT to promote colorectal cancer cuproptosis under copper stress.Cell Rep202642391001PubTator, text miningPubMed
Integrative Analysis of Oxidative Stress and Cellular Senescence Pathways in Chronic Obstructive Pulmonary Disease.Genes (Basel)202642353844PubTator, text miningPubMed
p53 overrides METTL5 loss-induced tumor suppression via mitochondrial respiration.Proc Natl Acad Sci U S A202642341042PubTator, text miningPubMed
Haplotype-resolved DNA methylation at the APOE locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk.NPJ Dement202642327426PubTator, text miningPubMed
Personalized polygenic profiling based on the genetic architecture of lipid metabolism in the Russian population.Front Cardiovasc Med202642311766PubTator, text miningPubMed

1 to 10 of 2,093

See all 2,093 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10452

GET https://conductscience.org/api/genes/v1/10452/patents?page=2