Gene · 10452
TOMM40: translocase of outer mitochondrial membrane 40
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TOMM40: translocase of outer mitochondrial membrane 40. Genes, record 10452. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10452
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O96008 | Mitochondrial import receptor subunit TOM40 homolog | 361 | 12 | Ensembl, GeneID, HGNC |
Source UniProt
Patents52
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67713 | O96008 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67714 | O96008 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67715 | O96008 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1389 | O96008 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 164 | O96008 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1024 | O96008 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4457 | O96008 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 164 | O96008 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1024 | O96008 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1389 | O96008 | Espacenet |
1 to 10 of 52
See all 52 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,318
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TOMM40 papers | Newest fiscal year |
|---|---|---|---|
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 53 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 18 | 2025 |
| U19AG024904 | Alzheimer's Disease Neuroimaging Initiative (ADNI4) | 14 | 2025 |
| R01NS017950 | Precursors of Stroke Incidence and Prognosis | 12 | 2025 |
| U01AG009740 | Health and Retirement Study: Yrs 35-40 | 12 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 10 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 10 | 2025 |
| U24AG041689 | THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE | 10 | 2025 |
| P30AG034424 | Center for Population Health and Aging | 9 | 2025 |
| P30AG066444 | Alzheimer's Disease Research Center | 9 | 2025 |
1 to 10 of 2,318Source NIH's project files
See all 2,318 nih grantsPapers2,093
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The DDIT4L-TOM40-ATP5A pathway suppresses glioblastoma oncogenesis. | Genes Dis | 2027 | 42733534 | PubTator, text mining | PubMed |
| Alzheimer's Disease DNA Methylation Index (AD-DMI) and its Association with Late-Life Cognitive Function. | NPJ Dement | 2026 | 42583477 | PubTator, text mining | PubMed |
| New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors. | Psychogeriatrics | 2026 | 42535978 | PubTator, text mining | PubMed |
| Targeting TOMM40 unleashes immunogenic mitophagy to facilitate antigen presentation and immunotherapy sensitization. | J Immunother Cancer | 2026 | 42508829 | PubTator, text mining | PubMed |
| TOMM40/FADS2 Expression Ratio Predicts the Sensitivity to mTOR Inhibitors in Triple-Negative Breast Cancer. | Cancer Med | 2026 | 42470318 | PubTator, text mining | PubMed |
| HPD is a copper-binding protein that interacts with DLAT to promote colorectal cancer cuproptosis under copper stress. | Cell Rep | 2026 | 42391001 | PubTator, text mining | PubMed |
| Integrative Analysis of Oxidative Stress and Cellular Senescence Pathways in Chronic Obstructive Pulmonary Disease. | Genes (Basel) | 2026 | 42353844 | PubTator, text mining | PubMed |
| p53 overrides METTL5 loss-induced tumor suppression via mitochondrial respiration. | Proc Natl Acad Sci U S A | 2026 | 42341042 | PubTator, text mining | PubMed |
| Haplotype-resolved DNA methylation at the APOE locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk. | NPJ Dement | 2026 | 42327426 | PubTator, text mining | PubMed |
| Personalized polygenic profiling based on the genetic architecture of lipid metabolism in the Russian population. | Front Cardiovasc Med | 2026 | 42311766 | PubTator, text mining | PubMed |
1 to 10 of 2,093
See all 2,093 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10452
GET https://conductscience.org/api/genes/v1/10452/patents?page=2