Gene · 10454
TAB1: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TAB1: TGF-beta activated kinase 1 (MAP3K7) binding protein 1. Genes, record 10454. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10454
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15750 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | 504 | 35 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 66902 | Q15750 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 313 | Q15750 | Espacenet |
| WO 2025178959 A1 | 2025-08-28 | 20 | Q15750 | Espacenet |
| JP 2025524002 A | 2025-07-25 | 23 | Q15750 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 313 | Q15750 | Espacenet |
| KR 1020250039465 A | 2025-03-20 | 23 | Q15750 | Espacenet |
| JP 2024023699 A | 2024-02-21 | 23 | Q15750 | Espacenet |
| JP 2024505890 A | 2024-02-08 | 23 | Q15750 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 152 | Q15750 | Espacenet |
| JP 2023509886 A | 2023-03-10 | 23 | Q15750 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,132
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TAB1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 17 | 2025 |
| R35GM127121 | Cell signaling by G protein-coupled receptors | 5 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 4 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 4 | 2025 |
| K12GM068524 | San Diego IRACDA Scholars Program | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 3 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| R01GM121718 | Beyond the Active Site: Structure Informed Novel Regulatory Mechanisms and Functional Modulation of O-GlcNAc Transferase | 3 | 2025 |
| U01DK062413 | Determining genomic and host-environment contributions to IBD phenotypes | 3 | 2025 |
1 to 10 of 1,132Source NIH's project files
See all 1,132 nih grantsPapers1,567
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| LncRNA-MSTRG.16919.1 regulates the proliferation of BHV-1 in MDBK cells through TAK1/TAB1/TAB2/TAB3 complexes. | BMC Vet Res | 2026 | 42432683 | PubTator, text mining | PubMed |
| p38 MAP kinase senses short-chain fatty acids to attenuate Toll-like receptor signaling and intestinal inflammation. | Sci Adv | 2026 | 42430494 | PubTator, text mining | PubMed |
| Tribranched Multiblock Copolymers Mimicking the Molecular Claw Design in N-Type Conjugated Polymers for High-Yield Semiconducting Carbon Nanotube Sorting and Phototransistor Memory Applications. | ACS Appl Mater Interfaces | 2026 | 42284118 | PubTator, text mining | PubMed |
| The seven human coronavirus main proteases exhibit differential modulation of NF-κB suppression via TAB1 cleavage. | Commun Biol | 2026 | 42168570 | PubTator, text mining | PubMed |
| E2F3 activates NF-κB signaling through TRIM26 mediated TAB1 ubiquitination in pancreatic cancer. | Int J Biol Sci | 2026 | 42088415 | PubTator, text mining | PubMed |
| SARS-CoV-2 Nsp1 suppresses the canonical NF-κB pathway by promoting ubiquitin-dependent degradation of TAK1 kinase. | PLoS Pathog | 2026 | 42081588 | PubTator, text mining | PubMed |
| The Multifaceted Roles of GPR120 in Central Nervous System Disorders: Mechanistic Insights and Therapeutic Implications. | Mol Neurobiol | 2026 | 41915334 | PubTator, text mining | PubMed |
| Development of a novel immune infiltration-based gene signature to predict prognosis and immunotherapy response of a novel anti-PD-L1/TGF-β bifunctional fusion protein in recurrent cervical cancer. | Hum Vaccin Immunother | 2026 | 41866914 | PubTator, text mining | PubMed |
| Maternal docosahexaenoic acid and eicosapentaenoic acid supplementation: effects and mechanisms on lipid metabolism in the offspring. | Front Nutr | 2026 | 41798834 | PubTator, text mining | PubMed |
| Hypomethylating Agents and Venetoclax Based Triplets Targeting FLT3, IDH and KMT2A in Acute Myeloid Leukemia: Current Studies and Challenges of a Tailored Approach. | Cancers (Basel) | 2026 | 41749868 | PubTator, text mining | PubMed |
1 to 10 of 1,567
See all 1,567 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10454
GET https://conductscience.org/api/genes/v1/10454/patents?page=2