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Gene · 10454

TAB1: TGF-beta activated kinase 1 (MAP3K7) binding protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TAB1: TGF-beta activated kinase 1 (MAP3K7) binding protein 1. Genes, record 10454. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10454

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Gene

Symbol
TAB1
HGNC
Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 1
HGNC
NCBI Gene ID
10454
NCBI Gene
HGNC ID
HGNC:18157
HGNC
Ensembl
ENSG00000100324
NCBI Gene
Aliases
3'-Tab1, MAP3K7IP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15750TGF-beta-activated kinase 1 and MAP3K7-binding protein 150435Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466902Q15750Espacenet
EP 4650780 A22025-11-19313Q15750Espacenet
WO 2025178959 A12025-08-2820Q15750Espacenet
JP 2025524002 A2025-07-2523Q15750Espacenet
JP 2025517970 A2025-06-12313Q15750Espacenet
KR 1020250039465 A2025-03-2023Q15750Espacenet
JP 2024023699 A2024-02-2123Q15750Espacenet
JP 2024505890 A2024-02-0823Q15750Espacenet
JP 2023123507 A2023-09-05152Q15750Espacenet
JP 2023509886 A2023-03-1023Q15750Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,132

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTAB1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
R35GM127121Cell signaling by G protein-coupled receptors52025
P30CA016086Cancer Center Support Grant42025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025
K12GM068524San Diego IRACDA Scholars Program32025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
R01GM121718Beyond the Active Site: Structure Informed Novel Regulatory Mechanisms and Functional Modulation of O-GlcNAc Transferase32025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes32025

1 to 10 of 1,132Source NIH's project files

See all 1,132 nih grants

Papers1,567

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
LncRNA-MSTRG.16919.1 regulates the proliferation of BHV-1 in MDBK cells through TAK1/TAB1/TAB2/TAB3 complexes.BMC Vet Res202642432683PubTator, text miningPubMed
p38 MAP kinase senses short-chain fatty acids to attenuate Toll-like receptor signaling and intestinal inflammation.Sci Adv202642430494PubTator, text miningPubMed
Tribranched Multiblock Copolymers Mimicking the Molecular Claw Design in N-Type Conjugated Polymers for High-Yield Semiconducting Carbon Nanotube Sorting and Phototransistor Memory Applications.ACS Appl Mater Interfaces202642284118PubTator, text miningPubMed
The seven human coronavirus main proteases exhibit differential modulation of NF-κB suppression via TAB1 cleavage.Commun Biol202642168570PubTator, text miningPubMed
E2F3 activates NF-κB signaling through TRIM26 mediated TAB1 ubiquitination in pancreatic cancer.Int J Biol Sci202642088415PubTator, text miningPubMed
SARS-CoV-2 Nsp1 suppresses the canonical NF-κB pathway by promoting ubiquitin-dependent degradation of TAK1 kinase.PLoS Pathog202642081588PubTator, text miningPubMed
The Multifaceted Roles of GPR120 in Central Nervous System Disorders: Mechanistic Insights and Therapeutic Implications.Mol Neurobiol202641915334PubTator, text miningPubMed
Development of a novel immune infiltration-based gene signature to predict prognosis and immunotherapy response of a novel anti-PD-L1/TGF-β bifunctional fusion protein in recurrent cervical cancer.Hum Vaccin Immunother202641866914PubTator, text miningPubMed
Maternal docosahexaenoic acid and eicosapentaenoic acid supplementation: effects and mechanisms on lipid metabolism in the offspring.Front Nutr202641798834PubTator, text miningPubMed
Hypomethylating Agents and Venetoclax Based Triplets Targeting FLT3, IDH and KMT2A in Acute Myeloid Leukemia: Current Studies and Challenges of a Tailored Approach.Cancers (Basel)202641749868PubTator, text miningPubMed

1 to 10 of 1,567

See all 1,567 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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