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Gene · 10457

GPNMB: glycoprotein nmb

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GPNMB: glycoprotein nmb. Genes, record 10457. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10457

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Gene

Symbol
GPNMB
HGNC
Name
glycoprotein nmb
HGNC
NCBI Gene ID
10457
NCBI Gene
HGNC ID
HGNC:4462
HGNC
Ensembl
ENSG00000136235
NCBI Gene
Aliases
HGFIN, NMB, PLCA3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14956Transmembrane glycoprotein NMB5720Ensembl, GeneID, HGNC

Source UniProt

Patents97

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4772193 A12026-07-08209Q14956Espacenet
EP 4772536 A12026-07-08209Q14956Espacenet
EP 4650780 A22025-11-1910510Q14956Espacenet
EP 4640849 A22025-10-291600Q14956Espacenet
EP 4641201 A22025-10-2910858Q14956Espacenet
JP 2025147176 A2025-10-066152Q14956Espacenet
JP 2025529142 A2025-09-041774Q14956Espacenet
JP 2025529142 A2025-09-046533Q14956Espacenet
JP 2025527204 A2025-08-201Q14956Espacenet
WO 2025166040 A12025-08-07241Q14956Espacenet

1 to 10 of 97

See all 97 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
GLEMBATUMUMABCHEMBL2108707Transmembrane glycoprotein NMB binding agentBINDING AGENTChEMBL
GLEMBATUMUMAB VEDOTINCHEMBL1743028Transmembrane glycoprotein NMB binding agentBINDING AGENTChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03473691GLEMBATUMUMAB VEDOTINEARLY_PHASE1ClinicalTrials.gov
NCT03326258GLEMBATUMUMAB VEDOTINPHASE1/PHASE2ClinicalTrials.gov
NCT03067935GLEMBATUMUMAB VEDOTINClinicalTrials.gov
NCT02713828GLEMBATUMUMAB VEDOTINPHASE1/PHASE22019-07-16ClinicalTrials.gov
NCT02487979GLEMBATUMUMAB VEDOTINPHASE22018-10-15ClinicalTrials.gov
NCT02363283GLEMBATUMUMAB VEDOTINPHASE22020-08-21ClinicalTrials.gov
NCT02302339GLEMBATUMUMAB VEDOTINPHASE22019-09-06ClinicalTrials.gov
NCT01997333GLEMBATUMUMAB VEDOTINPHASE22019-03-08ClinicalTrials.gov
NCT01156753GLEMBATUMUMAB VEDOTINPHASE2ClinicalTrials.gov
NCT00704158GLEMBATUMUMAB VEDOTINPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,518

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGPNMB papersNewest fiscal year
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer112025
ZIDBC011089Clinical Nursing and Data Management Core102025
UL1TR001863Yale Clinical and Translational Science Award92025
ZIABC011043Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene72025
P30CA016672Cancer Center Support Grant62025
ZICBC011044Tissue Processing-Sequencing Facility62025
P30CA008748Cancer Center Support Grant52025
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene52025
P30AG066511Goizueta Alzheimer's Disease Research Center42025
P30AG066519The Alzheimer's Disease Research Center at the University of California, Irvine42025

1 to 10 of 1,518Source NIH's project files

See all 1,518 nih grants

Papers2,043

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
High expression of glycoprotein non-metastatic melanoma protein B is associated with resistance to neoadjuvant chemotherapy in triple-negative breast cancer.Histol Histopathol202642806768PubTator, text miningPubMed
Explainable Artificial Intelligence and Gene-Network Analysis Prioritise a TREM2/LGALS3/GPNMB Scar-Associated Macrophage Programme in Human Liver Cirrhosis.Int J Mol Sci202642794453PubTator, text miningPubMed
Immunoreactivity of GPNMB (glycoprotein nonmetastatic melanoma protein B) across the spectrum of uterine mesenchymal tumours.Histopathology202642791032PubTator, text miningPubMed
Disentangling the Cellular Composition of FLCN-Mutated Tumors in Birt-Hogg-Dubé Syndrome by Spatial Transcriptomics.Mod Pathol202642754233PubTator, text miningPubMed
An Underrecognized Cause of Recurrent Spontaneous Pneumothorax: Birt-Hogg-Dubé Syndrome With Isolated Pulmonary Manifestation.Respirol Case Rep202642719447PubTator, text miningPubMed
Multi-omics mapping of PSC genetic risk to a high TWAS-active JAML+ lipid-associated macrophage program: bridging single-cell heterogeneity, spatial fibrotic niches, and machine learning selection.Front Cell Dev Biol202642707798PubTator, text miningPubMed
[Birt-Hogg-Dubé syndrome-associated renal tumors: a clinicopathological and molecular genetic analysis of ten cases].Zhonghua Bing Li Xue Za Zhi202642706109PubTator, text miningPubMed
Longitudinal assessment of glomerular and tubular kidney function after COVID-19: a prospective cohort study.Scand J Clin Lab Invest202642690026PubTator, text miningPubMed
Aggressive high-grade papillary-patterned renal cell carcinomas harboring FLCN mutations: expanding the clinicopathological spectrum in Birt-Hogg-Dubé syndrome and sporadic cases.Virchows Arch202642687010PubTator, text miningPubMed
GPNMB promotes double-membrane vesicle accumulation and facilitates structural protein transport during PEDV infection.Virulence202642678062PubTator, text miningPubMed

1 to 10 of 2,043

See all 2,043 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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