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MERTK: MER proto-oncogene, tyrosine kinase

1 protein, 128 patents, 1 drug, 5 trials, 3,448 NIH grants and 5,192 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMERTKHGNC
NameMER proto-oncogene, tyrosine kinaseHGNC
NCBI Gene ID10461NCBI Gene
HGNC IDHGNC:7027HGNC
EnsemblENSG00000153208NCBI Gene
AliasesMER, RP38, Tyro12, c-Eyk, c-mer, merNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q12866Tyrosine-protein kinase Mer99942Ensembl, GeneID, HGNCUniProt

Patents 128

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-1965Q12866Espacenet
JP 2026503049 A2026-01-272Q12866Espacenet
EP 4667578 A22025-12-24162Q12866Espacenet
EP 4650780 A22025-11-193613Q12866Espacenet
EP 4646212 A12025-11-122Q12866Espacenet
EP 4641201 A22025-10-293211Q12866Espacenet
EP 4633648 A12025-10-2276Q12866Espacenet
JP 2025131621 A2025-09-09162Q12866Espacenet
JP 2025529142 A2025-09-042600Q12866Espacenet
US 12371689 B22025-07-292600Q12866Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
NINGETINIBCHEMBL3984441Proto-oncogene tyrosine-protein kinase MER inhibitorINHIBITORChEMBL

Trials 5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04992858NINGETINIBPHASE2ClinicalTrials.gov
NCT03876925NINGETINIBPHASE1/PHASE2ClinicalTrials.gov
NCT03838848NINGETINIBPHASE2ClinicalTrials.gov
NCT03758287NINGETINIBPHASE1/PHASE2ClinicalTrials.gov
NCT03125876NINGETINIBPHASE1ClinicalTrials.gov

NIH grants 3448

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant272,025NIH's project files
P30CA008748Cancer Center Support Grant262,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant252,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award192,025NIH's project files
R01EY018213Defining Barriers to Gene Therapy172,025NIH's project files
P30CA013696Cancer Center Support Grant162,025NIH's project files
P30CA016086Cancer Center Support Grant162,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)132,025NIH's project files
P30EY014801Miami Center for Vision Research112,025NIH's project files
R01EY024698Gene Editing and Silencing in Phototransduction112,025NIH's project files

Papers 5192

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826818PubTator, text miningPubMed
42826448PubTator, text miningPubMed
42812562PubTator, text miningPubMed
42811049PubTator, text miningPubMed
42803451PubTator, text miningPubMed
42795518PubTator, text miningPubMed
42794437PubTator, text miningPubMed
42778661PubTator, text miningPubMed
42770830PubTator, text miningPubMed
42753640PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license