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Gene · 10498

CARM1: coactivator associated arginine methyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CARM1: coactivator associated arginine methyltransferase 1. Genes, record 10498. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10498

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Gene

Symbol
CARM1
HGNC
Name
coactivator associated arginine methyltransferase 1
HGNC
NCBI Gene ID
10498
NCBI Gene
HGNC ID
HGNC:23393
HGNC
Ensembl
ENSG00000142453
NCBI Gene
Aliases
PRMT4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q86X55Histone-arginine methyltransferase CARM160833Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195622Q86X55Espacenet
JP 2025147176 A2025-10-062054Q86X55Espacenet
JP 2025529142 A2025-09-045722Q86X55Espacenet
US 12371689 B22025-07-295722Q86X55Espacenet
JP 2025517970 A2025-06-125622Q86X55Espacenet
JP 2025028160 A2025-02-282054Q86X55Espacenet
KR 1020250010750 A2025-01-212054Q86X55Espacenet
JP 2024109657 A2024-08-142061Q86X55Espacenet
JP 2023518396 A2023-05-0110Q86X55Espacenet
US 11564998 B22023-01-315497Q86X55Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,482

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCARM1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant252025
P30CA008748Cancer Center Support Grant202025
R01HD007857Sex Hormone Receptor Component And The Cell Genome132025
R01HD008188Reproductive Hormones - Biological and Molecular Actions132025
P30CA014520UW Comprehensive Cancer Center Support92025
R01CA166835Targeted therapy for t(8;21)+ AML92025
R01CA236356Protein arginine methylation in breast cancer92025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant82025
P30CA010815Consolidated Basic Cancer Research Program62025
ZIAAG000511Post-transcriptional control of Proliferation, Stress Response & Carcinogenesis62025

1 to 10 of 1,482Source NIH's project files

See all 1,482 nih grants

Papers2,160

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting CARM1 impairs DNA damage repair and attenuates B-cell acute lymphoblastic leukemia progression.Biochim Biophys Acta Mol Basis Dis202742669369PubTator, text miningPubMed
CARM1 as a therapeutic target: The future of disease-modifying therapies for epilepsy.Mol Cell Neurosci202642716264PubTator, text miningPubMed
CARM1 in human cancer: a multifunctional epigenetic node driving tumor plasticity and therapeutic vulnerability.Biochim Biophys Acta Rev Cancer202642679970PubTator, text miningPubMed
CARM1: an epigenetic brake on cDC1-mediated antitumor immunity.Trends Immunol202642618461PubTator, text miningPubMed
A bibliometric and visual analysis of PRMTs research publications for cancer (2006-2024).Medicine (Baltimore)202642601760PubTator, text miningPubMed
Decoding the Complexity of Hepatocellular Carcinoma: Clinical Challenges and Targeting HuR as a Novel Therapeutic Strategy.Livers202642583674PubTator, text miningPubMed
Depletion of CARM1 slows in vivo tumorigenicity and rewires developmental programming in glioma stem-like cells.Cell Rep202642570242PubTator, text miningPubMed
Targeting PRMTs with small-molecule inhibitors: a comprehensive review.RSC Med Chem202642549137PubTator, text miningPubMed
Protein arginine methyltransferases as regulators of phase separation: implications in cancer and neurodegenerative diseases.Eur Biophys J202642484672PubTator, text miningPubMed
A novel combination approach targeting P300 and DNA-PK exploits epigenetic dependencies in acute myeloid leukemia.Mol Ther Oncol202642440809PubTator, text miningPubMed

1 to 10 of 2,160

See all 2,160 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10498

GET https://conductscience.org/api/genes/v1/10498/patents?page=2