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Gene · 10499

NCOA2: nuclear receptor coactivator 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NCOA2: nuclear receptor coactivator 2. Genes, record 10499. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10499

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Gene

Symbol
NCOA2
HGNC
Name
nuclear receptor coactivator 2
HGNC
NCBI Gene ID
10499
NCBI Gene
HGNC ID
HGNC:7669
HGNC
Ensembl
ENSG00000140396
NCBI Gene
Aliases
GRIP1, KAT13C, NCoA-2, SRC-2, SRC2, TIF2, bHLHe75
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15596Nuclear receptor coactivator 21,464383Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456095Q15596Espacenet
EP 4650780 A22025-11-1913011Q15596Espacenet
EP 4641201 A22025-10-2914614Q15596Espacenet
JP 2025147176 A2025-10-0615344Q15596Espacenet
JP 2025517969 A2025-06-1214614Q15596Espacenet
JP 2025517970 A2025-06-1213011Q15596Espacenet
JP 2025028160 A2025-02-2815344Q15596Espacenet
KR 1020250010750 A2025-01-2115344Q15596Espacenet
JP 2024109657 A2024-08-1415183Q15596Espacenet
US 11446398 B22022-09-2058306Q15596Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,036

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNCOA2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant472025
R01HD007857Sex Hormone Receptor Component And The Cell Genome452025
R01HD008188Reproductive Hormones - Biological and Molecular Actions442025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant392025
P30CA016672Cancer Center Support Grant212025
P50CA217694SPORE in Soft Tissue Sarcoma152025
P30CA021765Cancer Center Support Grant (CCSG)132025
P30DK056338Texas Medical Center Digestive Diseases Center112025
ZIADK075069Modeling gene transcription92025
R01DK058110Dose-Dependent Effects of Hormone on the Activity of Estrogen Receptor Enhancers and Target Genes82025

1 to 10 of 2,036Source NIH's project files

See all 2,036 nih grants

Papers3,077

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Tandem Double Inversion Resolves the Structural Paradox Underlying Recurrent KAT6A::NCOA2 Fusion in Acute Myeloid Leukemia.Genes Chromosomes Cancer202642704008PubTator, text miningPubMed
MEIS1::NCOA2 Rearranged Spindle Cell Neoplasm of Vulva With Unusual Low-Grade Morphology.Genes Chromosomes Cancer202642629629PubTator, text miningPubMed
Comparative Genomics Provides Insights into the Evolutionary Origin and Structural Diversification of Steroid Receptor Coactivators (SRCs 1-3).Molecules202642588544PubTator, text miningPubMed
Integrated Clinicopathologic and Multiomic Profiling Reveals MEIS1-Rearranged Sarcoma as a Distinct Entity With 2 Prognostic Subgroups.Mod Pathol202642471200PubTator, text miningPubMed
Corrigendum to "Hyperoside mitigates PCOS-associated adipogenesis and insulin resistance by regulating NCOA2-mediated PPAR-γ ubiquitination and degradation" [Life Sci. 364 (2025) 123417].Life Sci202642469139PubTator, text miningPubMed
Biphenotypic Sinonasal Sarcomas with Recurrent PAX3::FOXO6 Gene Fusion.Head Neck Pathol202642446761PubTator, text miningPubMed
Distinct nuclear localization signals confer differential microtubule dependence among ZFTA fusion oncoproteins.J Biol Chem202642442495PubTator, text miningPubMed
Evaluation of the Ligand-Dependent Coactivator Recruitment of the Nuclear Receptor Pregnane X Receptor Using Its Three-Alanine Residues-Inserted Mutant.Biol Pharm Bull202642324158PubTator, text miningPubMed
Lipid metabolism-related gene expression predicts prognostic outcomes in lung adenocarcinoma.Transl Cancer Res202642180928PubTator, text miningPubMed
A Novel MEIS1::NCOA2 Fusion Gene in Acute Myeloid Leukemia.Genes Chromosomes Cancer202642138464PubTator, text miningPubMed

1 to 10 of 3,077

See all 3,077 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10499

GET https://conductscience.org/api/genes/v1/10499/patents?page=2