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Gene · 10507

SEMA4D: semaphorin 4D

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SEMA4D: semaphorin 4D. Genes, record 10507. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10507

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Gene

Symbol
SEMA4D
HGNC
Name
semaphorin 4D
HGNC
NCBI Gene ID
10507
NCBI Gene
HGNC ID
HGNC:10732
HGNC
Ensembl
ENSG00000187764
NCBI Gene
Aliases
A8, BB18, C9orf164, CD100, COLL4, FLJ39737, GR3, M-sema-G, SEMAJ, coll-4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92854Semaphorin-4D8622Ensembl, GeneID, HGNC

Source UniProt

Patents139

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4717270 A22026-04-011Q92854Espacenet
EP 4650780 A22025-11-197295Q92854Espacenet
EP 4641201 A22025-10-297248Q92854Espacenet
JP 2025147176 A2025-10-0611921Q92854Espacenet
JP 2025147176 A2025-10-0611924Q92854Espacenet
JP 2025147176 A2025-10-0611925Q92854Espacenet
JP 2025147176 A2025-10-0611928Q92854Espacenet
JP 2025529142 A2025-09-043893Q92854Espacenet
JP 2025529142 A2025-09-047664Q92854Espacenet
US 12371689 B22025-07-293893Q92854Espacenet

1 to 10 of 139

See all 139 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
PEPINEMABCHEMBL4297884Semaphorin-4D inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05378464PEPINEMABPHASE1ClinicalTrials.gov
NCT04815720PEPINEMABPHASE1/PHASE2ClinicalTrials.gov
NCT04381468PEPINEMABPHASE1/PHASE2ClinicalTrials.gov
NCT03769155PEPINEMABPHASE1ClinicalTrials.gov
NCT03425461PEPINEMABPHASE1ClinicalTrials.gov
NCT03373188PEPINEMABPHASE1ClinicalTrials.gov
NCT03320330PEPINEMABPHASE1/PHASE22022-04-26ClinicalTrials.gov
NCT03268057PEPINEMABPHASE1/PHASE2ClinicalTrials.gov
NCT02481674PEPINEMABPHASE2ClinicalTrials.gov
NCT01764737PEPINEMABPHASE1ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,052

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSEMA4D papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment42025
P30CA016672Cancer Center Support Grant32025
P30CA036727Buffett Cancer Center Support Grant32025
R01DE029709Osteoimmunology of Retarded Bone Regeneration in Periodontitis32025
R35GM126985Multi-view self-supervised deep learning for biological sequences and beyond32025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky22025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE22025
P20GM109025Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission22025
P30AI027763UCSF-Bay Area Center for AIDS Research22025

1 to 10 of 1,052Source NIH's project files

See all 1,052 nih grants

Papers1,823

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Context-Dependent Roles of the Plexin-B Family Across Neurological, Oncological, Immune and Cardiovascular Disorders: Mechanisms and Therapeutic Implications.Life (Basel)202642795389PubTator, text miningPubMed
Independent prognostic value of semaphorin-4D, interleukin-1β and complement activation in newly diagnosed multiple myeloma patients.Haematologica202642687818PubTator, text miningPubMed
Targeting Semaphorin-plexin Signaling in Glioblastoma: Implications for Tumor Invasion, Angiogenesis, and Treatment Resistance.Curr Neurovasc Res202642634324PubTator, text miningPubMed
Circ_0024085 and circ_0000339 as potential biomarkers for the diagnosis of ankylosing spondylitis.Biomark Med202642605819PubTator, text miningPubMed
Differences in immune-related semaphorin levels in the CSF and serum of newly diagnosed, treatment-naive patients with relapsing-remitting multiple sclerosis: a case-control study.Front Neurol202642524290PubTator, text miningPubMed
Proteomic and glycosylation biomarkers in rheumatoid arthritis: advancing early diagnosis and precision therapy.Clin Proteomics202642402554PubTator, text miningPubMed
Diverse Roles of Semaphorins on T Cell Activation, Differentiation, Migration, and Effector Functions.Cells202642346074PubTator, text miningPubMed
Cell-autonomous co-stimulatory function of membrane-bound CD100 promotes activation and differentiation of HBcAg-specific CD8+ T cells.Front Immunol202642317326PubTator, text miningPubMed
Single-cell Transcriptomics Inference of Neutrophil-mast Cell Communication Programs in Periodontitis.Curr Gene Ther202642316490PubTator, text miningPubMed
Region-Specific Alterations in the Trabecular Meshwork in High- and Low-Tension Glaucoma.Cureus202642272591PubTator, text miningPubMed

1 to 10 of 1,823

See all 1,823 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10507

GET https://conductscience.org/api/genes/v1/10507/patents?page=2