Gene · 10507
SEMA4D: semaphorin 4D
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SEMA4D: semaphorin 4D. Genes, record 10507. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10507
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92854 | Semaphorin-4D | 862 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents139
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4717270 A2 | 2026-04-01 | 1 | Q92854 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7295 | Q92854 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7248 | Q92854 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 11921 | Q92854 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 11924 | Q92854 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 11925 | Q92854 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 11928 | Q92854 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3893 | Q92854 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7664 | Q92854 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3893 | Q92854 | Espacenet |
1 to 10 of 139
See all 139 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| PEPINEMAB | CHEMBL4297884 | Semaphorin-4D inhibitor | INHIBITOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05378464 | PEPINEMAB | PHASE1 | ClinicalTrials.gov | |
| NCT04815720 | PEPINEMAB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT04381468 | PEPINEMAB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT03769155 | PEPINEMAB | PHASE1 | ClinicalTrials.gov | |
| NCT03425461 | PEPINEMAB | PHASE1 | ClinicalTrials.gov | |
| NCT03373188 | PEPINEMAB | PHASE1 | ClinicalTrials.gov | |
| NCT03320330 | PEPINEMAB | PHASE1/PHASE2 | 2022-04-26 | ClinicalTrials.gov |
| NCT03268057 | PEPINEMAB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT02481674 | PEPINEMAB | PHASE2 | ClinicalTrials.gov | |
| NCT01764737 | PEPINEMAB | PHASE1 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants1,052
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SEMA4D papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| P30ES007033 | University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 3 | 2025 |
| R01DE029709 | Osteoimmunology of Retarded Bone Regeneration in Periodontitis | 3 | 2025 |
| R35GM126985 | Multi-view self-supervised deep learning for biological sequences and beyond | 3 | 2025 |
| P20GM103436 | IDeA Networks of Biomedical Research Excellence in Kentucky | 2 | 2025 |
| P20GM103449 | Vermont Biomedical Research Network-Vermont INBRE | 2 | 2025 |
| P20GM109025 | Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission | 2 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 2 | 2025 |
1 to 10 of 1,052Source NIH's project files
See all 1,052 nih grantsPapers1,823
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Context-Dependent Roles of the Plexin-B Family Across Neurological, Oncological, Immune and Cardiovascular Disorders: Mechanisms and Therapeutic Implications. | Life (Basel) | 2026 | 42795389 | PubTator, text mining | PubMed |
| Independent prognostic value of semaphorin-4D, interleukin-1β and complement activation in newly diagnosed multiple myeloma patients. | Haematologica | 2026 | 42687818 | PubTator, text mining | PubMed |
| Targeting Semaphorin-plexin Signaling in Glioblastoma: Implications for Tumor Invasion, Angiogenesis, and Treatment Resistance. | Curr Neurovasc Res | 2026 | 42634324 | PubTator, text mining | PubMed |
| Circ_0024085 and circ_0000339 as potential biomarkers for the diagnosis of ankylosing spondylitis. | Biomark Med | 2026 | 42605819 | PubTator, text mining | PubMed |
| Differences in immune-related semaphorin levels in the CSF and serum of newly diagnosed, treatment-naive patients with relapsing-remitting multiple sclerosis: a case-control study. | Front Neurol | 2026 | 42524290 | PubTator, text mining | PubMed |
| Proteomic and glycosylation biomarkers in rheumatoid arthritis: advancing early diagnosis and precision therapy. | Clin Proteomics | 2026 | 42402554 | PubTator, text mining | PubMed |
| Diverse Roles of Semaphorins on T Cell Activation, Differentiation, Migration, and Effector Functions. | Cells | 2026 | 42346074 | PubTator, text mining | PubMed |
| Cell-autonomous co-stimulatory function of membrane-bound CD100 promotes activation and differentiation of HBcAg-specific CD8+ T cells. | Front Immunol | 2026 | 42317326 | PubTator, text mining | PubMed |
| Single-cell Transcriptomics Inference of Neutrophil-mast Cell Communication Programs in Periodontitis. | Curr Gene Ther | 2026 | 42316490 | PubTator, text mining | PubMed |
| Region-Specific Alterations in the Trabecular Meshwork in High- and Low-Tension Glaucoma. | Cureus | 2026 | 42272591 | PubTator, text mining | PubMed |
1 to 10 of 1,823
See all 1,823 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10507
GET https://conductscience.org/api/genes/v1/10507/patents?page=2