Gene · 10551
AGR2: anterior gradient 2, protein disulphide isomerase family member
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AGR2: anterior gradient 2, protein disulphide isomerase family member. Genes, record 10551. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10551
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95994 | Anterior gradient protein 2 homolog | 175 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents128
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025539142 A | 2025-12-03 | 1 | O95994 | Espacenet |
| WO 2025242680 A1 | 2025-11-27 | 1 | O95994 | Espacenet |
| WO 2025242685 A1 | 2025-11-27 | 1 | O95994 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 12451 | O95994 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 613 | O95994 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5433 | O95994 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5433 | O95994 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 12451 | O95994 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 5518 | O95994 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 613 | O95994 | Espacenet |
1 to 10 of 128
See all 128 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants941
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AGR2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| R01DK044319 | Characterization of Mucosal Lymphocytes | 7 | 2025 |
| R01DK051362 | Regulation of Mucosal Lymphocytes | 7 | 2025 |
| R01DK088199 | Endoplasmic reticulum stress and intestinal inflammation | 7 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 5 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 3 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 3 | 2025 |
1 to 10 of 941Source NIH's project files
See all 941 nih grantsPapers1,931
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Anterior gradient 2 is overexpressed in extramammary Paget's disease and involved in cell survival. | J Dermatol Sci | 2026 | 42816243 | PubTator, text mining | PubMed |
| How Does Inter-Epitope Spacer Variation Within Artificial Immunogens Based on T-Cell Epitopes of Tick-Borne Encephalitis Virus Affect Immunogenicity? | Vaccines (Basel) | 2026 | 42797590 | PubTator, text mining | PubMed |
| Complementary intra- and extracellular AGR2 activities support epithelial ovarian cancer cell aggressiveness. | Oncogene | 2026 | 42575981 | PubTator, text mining | PubMed |
| Context-dependent promotion of epithelial-mesenchymal transition by IL-13Rα2/STAT6 signaling in colorectal cancer. | Mol Cell Biochem | 2026 | 42573974 | PubTator, text mining | PubMed |
| Integrative Analysis Identified an Eight-Gene Risk Signature Linked to CDK7 and Explored Its Association with HCC Progression via RelA Phosphorylation. | Oncol Res | 2026 | 42500561 | PubTator, text mining | PubMed |
| A rare cause of congenital diarrhea: a homozygous AGR2 frameshift variant in an infant. | Turk J Pediatr | 2026 | 42497436 | PubTator, text mining | PubMed |
| Genetic regulatory axis between AGR2 and ESR1 promotes breast cancer progression. | PLoS One | 2026 | 42384634 | PubTator, text mining | PubMed |
| Cross-species systems analysis distinguishes inflammatory remodeling from primary mucus secretory failure in inflammatory bowel disease. | Front Immunol | 2026 | 42344920 | PubTator, text mining | PubMed |
| Inhibition of AGR2 triggers secretion of GRP78 and sensitizes gastroesophageal junction adenocarcinoma cells to ER stress. | Biochem Biophys Res Commun | 2026 | 42330887 | PubTator, text mining | PubMed |
| Erratum: AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma. | Am J Transl Res | 2026 | 42325778 | PubTator, text mining | PubMed |
1 to 10 of 1,931
See all 1,931 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10551
GET https://conductscience.org/api/genes/v1/10551/patents?page=2