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Gene · 10551

AGR2: anterior gradient 2, protein disulphide isomerase family member

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AGR2: anterior gradient 2, protein disulphide isomerase family member. Genes, record 10551. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10551

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Gene

Symbol
AGR2
HGNC
Name
anterior gradient 2, protein disulphide isomerase family member
HGNC
NCBI Gene ID
10551
NCBI Gene
HGNC ID
HGNC:328
HGNC
Ensembl
ENSG00000106541
NCBI Gene
Aliases
AG-2, AG2, GOB-4, HAG-2, HEL-S-116, HPC8, PDIA17, RIFTD, XAG-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95994Anterior gradient protein 2 homolog1755Ensembl, GeneID, HGNC

Source UniProt

Patents128

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025539142 A2025-12-031O95994Espacenet
WO 2025242680 A12025-11-271O95994Espacenet
WO 2025242685 A12025-11-271O95994Espacenet
EP 4650780 A22025-11-1912451O95994Espacenet
JP 2025147176 A2025-10-06613O95994Espacenet
JP 2025529142 A2025-09-045433O95994Espacenet
US 12371689 B22025-07-295433O95994Espacenet
JP 2025517970 A2025-06-1212451O95994Espacenet
JP 2025062604 A2025-04-145518O95994Espacenet
JP 2025028160 A2025-02-28613O95994Espacenet

1 to 10 of 128

See all 128 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants941

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAGR2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant72025
R01DK044319Characterization of Mucosal Lymphocytes72025
R01DK051362Regulation of Mucosal Lymphocytes72025
R01DK088199Endoplasmic reticulum stress and intestinal inflammation72025
P30DK034854Integrated Epithelial and Muscosal Biology52025
P30CA062203Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30CA093373Cancer Center Support Grant P3032025
P50CA097186The Pacific Northwest Prostate Cancer SPORE32025

1 to 10 of 941Source NIH's project files

See all 941 nih grants

Papers1,931

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Anterior gradient 2 is overexpressed in extramammary Paget's disease and involved in cell survival.J Dermatol Sci202642816243PubTator, text miningPubMed
How Does Inter-Epitope Spacer Variation Within Artificial Immunogens Based on T-Cell Epitopes of Tick-Borne Encephalitis Virus Affect Immunogenicity?Vaccines (Basel)202642797590PubTator, text miningPubMed
Complementary intra- and extracellular AGR2 activities support epithelial ovarian cancer cell aggressiveness.Oncogene202642575981PubTator, text miningPubMed
Context-dependent promotion of epithelial-mesenchymal transition by IL-13Rα2/STAT6 signaling in colorectal cancer.Mol Cell Biochem202642573974PubTator, text miningPubMed
Integrative Analysis Identified an Eight-Gene Risk Signature Linked to CDK7 and Explored Its Association with HCC Progression via RelA Phosphorylation.Oncol Res202642500561PubTator, text miningPubMed
A rare cause of congenital diarrhea: a homozygous AGR2 frameshift variant in an infant.Turk J Pediatr202642497436PubTator, text miningPubMed
Genetic regulatory axis between AGR2 and ESR1 promotes breast cancer progression.PLoS One202642384634PubTator, text miningPubMed
Cross-species systems analysis distinguishes inflammatory remodeling from primary mucus secretory failure in inflammatory bowel disease.Front Immunol202642344920PubTator, text miningPubMed
Inhibition of AGR2 triggers secretion of GRP78 and sensitizes gastroesophageal junction adenocarcinoma cells to ER stress.Biochem Biophys Res Commun202642330887PubTator, text miningPubMed
Erratum: AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.Am J Transl Res202642325778PubTator, text miningPubMed

1 to 10 of 1,931

See all 1,931 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10551

GET https://conductscience.org/api/genes/v1/10551/patents?page=2