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Gene · 10558

SPTLC1: serine palmitoyltransferase long chain base subunit 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SPTLC1: serine palmitoyltransferase long chain base subunit 1. Genes, record 10558. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10558

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Gene

Symbol
SPTLC1
HGNC
Name
serine palmitoyltransferase long chain base subunit 1
HGNC
NCBI Gene ID
10558
NCBI Gene
HGNC ID
HGNC:11277
HGNC
Ensembl
ENSG00000090054
NCBI Gene
Aliases
ALS27, HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI, hLCB1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15269Serine palmitoyltransferase 147317Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463037O15269Espacenet
EP 4650780 A22025-11-192090O15269Espacenet
JP 2025529142 A2025-09-044437O15269Espacenet
US 12371689 B22025-07-294437O15269Espacenet
JP 2025517970 A2025-06-122090O15269Espacenet
KR 1020240032256 A2024-03-121O15269Espacenet
US 11446398 B22022-09-2077642O15269Espacenet
US 11400116 B22022-08-023487O15269Espacenet
JP 2022524081 A2022-04-27180613O15269Espacenet
US 11078247 B22021-08-0310943O15269Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants969

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSPTLC1 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy102025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant62025
R01AA011431FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays62025
ZIANS003129Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies62025
P30CA016059Massey Cancer Center - Cancer Center Support Grant52025
R35GM118128Neutral Sphingomyelinases and Bioactive Ceramides52025
P30DK020579Diabetes Research Center42025
P30DK056341Washington University Nutrition Obesity Research Center42025
P30GM124165NE-CAT: A Resource for Advanced Macromolecular Crystallography42025
ZIADK056014Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms42025

1 to 10 of 969Source NIH's project files

See all 969 nih grants

Papers1,447

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Function of HIF-1α in Regulating Sphingolipid Metabolism and Alleviating Oxidative Stress Damage in Callosobruchus chinensis Under Hypoxia.Insects202642783271PubTator, text miningPubMed
Natural product-based therapeutic strategies against Leishmania: mechanistic insights and emerging host-directed approaches.Front Microbiol202642746096PubTator, text miningPubMed
COPI Coatomer Regulates Several Steps of HDL Metabolism.Arterioscler Thromb Vasc Biol202642592650PubTator, text miningPubMed
Structural phase transition-aligned preheating reprograms lipid-derived flavor formation in cooked meat: A case of lamb.Food Chem202642330616PubTator, text miningPubMed
Health Equality and Socioeconomic Impact of Hereditary Sensory Neuropathy Type 1 (HSN1) in the UK.J Peripher Nerv Syst202642231561PubTator, text miningPubMed
Synergetic Effect of Fluorine Substitution and Substitution Position on Two Competing ESIPT Pathways in BR through DFT/TD-DFT Investigation.J Phys Chem A202642008641PubTator, text miningPubMed
ARID1B regulates sphingolipid metabolism and myelin development via STAG2: Mechanistic insights into ARID1B-related coffin-siris syndrome.Cell Signal202641967622PubTator, text miningPubMed
Transcriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer.Cancer Metab202641857765PubTator, text miningPubMed
Zanthoxylum armatum Essential Oil Attenuates MPP+-Induced Overexpression of Serine Palmitoyltransferase and Neurotoxicity in SH-SY5Y Cell Culture Model of Parkinson's Disease: Evidence From In Vitro and In Silico Studies.
Chem Biodivers202641852096PubTator, text miningPubMed
Efficacy Evaluation of N-Acyl-Phytosphingosine Prepared from Marula Oil Derived Fatty Acids in Skin Barrier Repair.Clin Cosmet Investig Dermatol202641809528PubTator, text miningPubMed

1 to 10 of 1,447

See all 1,447 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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