Gene · 10558
SPTLC1: serine palmitoyltransferase long chain base subunit 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SPTLC1: serine palmitoyltransferase long chain base subunit 1. Genes, record 10558. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10558
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15269 | Serine palmitoyltransferase 1 | 473 | 17 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63037 | O15269 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2090 | O15269 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4437 | O15269 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4437 | O15269 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2090 | O15269 | Espacenet |
| KR 1020240032256 A | 2024-03-12 | 1 | O15269 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 77642 | O15269 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3487 | O15269 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 180613 | O15269 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 10943 | O15269 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants969
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SPTLC1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 10 | 2025 |
| P30CA138313 | Medical University of South Carolina - Cancer Center Support Grant | 6 | 2025 |
| R01AA011431 | FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays | 6 | 2025 |
| ZIANS003129 | Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies | 6 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| R35GM118128 | Neutral Sphingomyelinases and Bioactive Ceramides | 5 | 2025 |
| P30DK020579 | Diabetes Research Center | 4 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 4 | 2025 |
| P30GM124165 | NE-CAT: A Resource for Advanced Macromolecular Crystallography | 4 | 2025 |
| ZIADK056014 | Mouse Models of Novel Sphingolipid Biology and Disease Mechanisms | 4 | 2025 |
1 to 10 of 969Source NIH's project files
See all 969 nih grantsPapers1,447
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Function of HIF-1α in Regulating Sphingolipid Metabolism and Alleviating Oxidative Stress Damage in Callosobruchus chinensis Under Hypoxia. | Insects | 2026 | 42783271 | PubTator, text mining | PubMed |
| Natural product-based therapeutic strategies against Leishmania: mechanistic insights and emerging host-directed approaches. | Front Microbiol | 2026 | 42746096 | PubTator, text mining | PubMed |
| COPI Coatomer Regulates Several Steps of HDL Metabolism. | Arterioscler Thromb Vasc Biol | 2026 | 42592650 | PubTator, text mining | PubMed |
| Structural phase transition-aligned preheating reprograms lipid-derived flavor formation in cooked meat: A case of lamb. | Food Chem | 2026 | 42330616 | PubTator, text mining | PubMed |
| Health Equality and Socioeconomic Impact of Hereditary Sensory Neuropathy Type 1 (HSN1) in the UK. | J Peripher Nerv Syst | 2026 | 42231561 | PubTator, text mining | PubMed |
| Synergetic Effect of Fluorine Substitution and Substitution Position on Two Competing ESIPT Pathways in BR through DFT/TD-DFT Investigation. | J Phys Chem A | 2026 | 42008641 | PubTator, text mining | PubMed |
| ARID1B regulates sphingolipid metabolism and myelin development via STAG2: Mechanistic insights into ARID1B-related coffin-siris syndrome. | Cell Signal | 2026 | 41967622 | PubTator, text mining | PubMed |
| Transcriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer. | Cancer Metab | 2026 | 41857765 | PubTator, text mining | PubMed |
Zanthoxylum armatum Essential Oil Attenuates MPP+-Induced Overexpression of Serine Palmitoyltransferase and Neurotoxicity in SH-SY5Y Cell Culture Model of Parkinson's Disease: Evidence From In Vitro and In Silico Studies. | Chem Biodivers | 2026 | 41852096 | PubTator, text mining | PubMed |
| Efficacy Evaluation of N-Acyl-Phytosphingosine Prepared from Marula Oil Derived Fatty Acids in Skin Barrier Repair. | Clin Cosmet Investig Dermatol | 2026 | 41809528 | PubTator, text mining | PubMed |
1 to 10 of 1,447
See all 1,447 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10558
GET https://conductscience.org/api/genes/v1/10558/patents?page=2