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NPC2: NPC intracellular cholesterol transporter 2
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Gene · 10577

Papers2,338

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,338

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TitleJournalYearPMIDFound bySource
Characterizing Allergen Profiles and Identifying Group 2 Allergens of Three Storage Mites: Acarus siro, Chortoglyphus arcuatus and Carpoglyphus lactis.Clin Exp Allergy202642777786PubTator, text miningPubMed
Meta-analysis of NPC2-mediated cholesterol transport in human cancers as a prognostic biomarker with therapeutic implications.Cell Cycle202642775549PubTator, text miningPubMed
Clinical and molecular spectrum of Niemann-Pick disease type C patients in India.Front Pediatr202642761304PubTator, text miningPubMed
A novel mTORC1-NPC2 axis suppresses lipophagy and drives atherosclerotic plaque progression.Biochim Biophys Acta Mol Basis Dis202642716142PubTator, text miningPubMed
M6PR/IGF2R double-knockout supplies therapeutic sources for mucolipidosis II and Niemann-Pick C2.J Biol Chem202642665096PubTator, text miningPubMed
Revisiting the Association of Central Precocious Puberty with Neurovisceral Diseases owing to a Girl with Niemann-Pick Disease Type C.J Clin Res Pediatr Endocrinol202642613861PubTator, text miningPubMed
A novel tumor necrosis factor-alpha-targeting protein degrader for the treatment of acute liver failure.Int J Biol Macromol202642607909PubTator, text miningPubMed
XGBoost-SHAP Interpretable Modeling Identifies and Validates an Eight-Gene Biomarker for Hepatic Encephalopathy Risk Prediction in Cirrhosis.Int J Mol Sci202642589578PubTator, text miningPubMed
Development of an immune escape-related gene prognostic signature using integrated single-cell and bulk RNA sequencing for immune microenvironment profiling in thyroid cancer.Korean J Physiol Pharmacol202642581622PubTator, text miningPubMed
Chemerin and NPC2 produced from iPSC-derived Müller glial cells promote retinal ganglion cell regeneration.Exp Eye Res202642575299PubTator, text miningPubMed
A single-cell sequencing-based prognostic model reveals HLA-DRA, NPC2, and PRPF38B as immune-regulatory tumor suppressors in non-small cell lung cancer.Front Cell Dev Biol202642564225PubTator, text miningPubMed
From astrocyte cholesterol synthesis to synaptic dysfunction: mechanisms of neuron-glia lipid coupling.Mol Biol Rep202642525165PubTator, text miningPubMed
Long-term misdiagnosis of Niemann-Pick disease type C as Wilson disease: A case report.Medicine (Baltimore)202642432889PubTator, text miningPubMed
Entosis remodels the immune microenvironment of osteosarcoma by regulating macrophage polarization: An integrated study based on multi-omics data and in vitro experiments.Transl Oncol202642407378PubTator, text miningPubMed
LvBlimp1 and LvHes1 coregulate the function of macrophage-like phagocytes in shrimp hemolymph.Fish Shellfish Immunol202642402322PubTator, text miningPubMed
Mendelian Randomization and Single-Cell RNA Sequencing Reveal CKAP4 and PFDN5 as Tumor Cell-Specific Causal Genes for Glioblastoma.Int J Gen Med202642369563PubTator, text miningPubMed
NPC2 Regulates Glioblastoma Cholesterol Metabolism and Malignant Behavior via GPX4-Linked Ferroptosis.Cell Biol Int202642360045PubTator, text miningPubMed
Diverse clinical spectrum of Niemann-Pick C: insights from a single center.J Pediatr Endocrinol Metab202642324936PubTator, text miningPubMed
SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism.Cell Rep202642287635PubTator, text miningPubMed
HKDC1 contributes to aberrant lysosome-mitochondria contact in Niemann-Pick disease type C.bioRxiv202642282761PubTator, text miningPubMed

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  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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