Gene · 10577
NPC2: NPC intracellular cholesterol transporter 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NPC2: NPC intracellular cholesterol transporter 2. Genes, record 10577. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10577
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P61916 | NPC intracellular cholesterol transporter 2 | 151 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents76
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 295 | P61916 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55714 | P61916 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 16721 | P61916 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 9443 | P61916 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7161 | P61916 | Espacenet |
| JP 2025118850 A | 2025-08-13 | 3 | P61916 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7161 | P61916 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 16721 | P61916 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 9443 | P61916 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 9443 | P61916 | Espacenet |
1 to 10 of 76
See all 76 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,433
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NPC2 papers | Newest fiscal year |
|---|---|---|---|
| P30DK020579 | Diabetes Research Center | 10 | 2025 |
| R01DK038389 | Lipid transport in the intestine | 9 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 7 | 2025 |
| ZIATR000018 | Drug Repurposing Screening for Rare and Neglected Diseases | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| ZIAHD008988 | Basic and Translational Studies of Inborn Errors of Metabolism | 5 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 4 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 4 | 2025 |
| T32NS007222 | Training in Clinical and Basic Neuroscience | 4 | 2025 |
| ZIAHD008989 | Clinical Investigations of Inborn Errors of Metabolism | 4 | 2025 |
1 to 10 of 1,433Source NIH's project files
See all 1,433 nih grantsPapers2,338
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Characterizing Allergen Profiles and Identifying Group 2 Allergens of Three Storage Mites: Acarus siro, Chortoglyphus arcuatus and Carpoglyphus lactis. | Clin Exp Allergy | 2026 | 42777786 | PubTator, text mining | PubMed |
| Meta-analysis of NPC2-mediated cholesterol transport in human cancers as a prognostic biomarker with therapeutic implications. | Cell Cycle | 2026 | 42775549 | PubTator, text mining | PubMed |
| Clinical and molecular spectrum of Niemann-Pick disease type C patients in India. | Front Pediatr | 2026 | 42761304 | PubTator, text mining | PubMed |
| A novel mTORC1-NPC2 axis suppresses lipophagy and drives atherosclerotic plaque progression. | Biochim Biophys Acta Mol Basis Dis | 2026 | 42716142 | PubTator, text mining | PubMed |
| M6PR/IGF2R double-knockout supplies therapeutic sources for mucolipidosis II and Niemann-Pick C2. | J Biol Chem | 2026 | 42665096 | PubTator, text mining | PubMed |
| Revisiting the Association of Central Precocious Puberty with Neurovisceral Diseases owing to a Girl with Niemann-Pick Disease Type C. | J Clin Res Pediatr Endocrinol | 2026 | 42613861 | PubTator, text mining | PubMed |
| A novel tumor necrosis factor-alpha-targeting protein degrader for the treatment of acute liver failure. | Int J Biol Macromol | 2026 | 42607909 | PubTator, text mining | PubMed |
| XGBoost-SHAP Interpretable Modeling Identifies and Validates an Eight-Gene Biomarker for Hepatic Encephalopathy Risk Prediction in Cirrhosis. | Int J Mol Sci | 2026 | 42589578 | PubTator, text mining | PubMed |
| Development of an immune escape-related gene prognostic signature using integrated single-cell and bulk RNA sequencing for immune microenvironment profiling in thyroid cancer. | Korean J Physiol Pharmacol | 2026 | 42581622 | PubTator, text mining | PubMed |
| Chemerin and NPC2 produced from iPSC-derived Müller glial cells promote retinal ganglion cell regeneration. | Exp Eye Res | 2026 | 42575299 | PubTator, text mining | PubMed |
1 to 10 of 2,338
See all 2,338 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10577
GET https://conductscience.org/api/genes/v1/10577/patents?page=2