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Gene · 10577

NPC2: NPC intracellular cholesterol transporter 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NPC2: NPC intracellular cholesterol transporter 2. Genes, record 10577. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10577

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Gene

Symbol
NPC2
HGNC
Name
NPC intracellular cholesterol transporter 2
HGNC
NCBI Gene ID
10577
NCBI Gene
HGNC ID
HGNC:14537
HGNC
Ensembl
ENSG00000119655
NCBI Gene
Aliases
EDDM1, HE1, NP-C2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61916NPC intracellular cholesterol transporter 21512Ensembl, GeneID, HGNC

Source UniProt

Patents76

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21295P61916Espacenet
JP 2026004568 A2026-01-1455714P61916Espacenet
EP 4650780 A22025-11-1916721P61916Espacenet
JP 2025147176 A2025-10-069443P61916Espacenet
JP 2025529142 A2025-09-047161P61916Espacenet
JP 2025118850 A2025-08-133P61916Espacenet
US 12371689 B22025-07-297161P61916Espacenet
JP 2025517970 A2025-06-1216721P61916Espacenet
JP 2025028160 A2025-02-289443P61916Espacenet
KR 1020250010750 A2025-01-219443P61916Espacenet

1 to 10 of 76

See all 76 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,433

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNPC2 papersNewest fiscal year
P30DK020579Diabetes Research Center102025
R01DK038389Lipid transport in the intestine92025
P30DK056341Washington University Nutrition Obesity Research Center72025
ZIATR000018Drug Repurposing Screening for Rare and Neglected Diseases62025
P30CA008748Cancer Center Support Grant52025
ZIAHD008988Basic and Translational Studies of Inborn Errors of Metabolism52025
P30CA013696Cancer Center Support Grant42025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025
T32NS007222Training in Clinical and Basic Neuroscience42025
ZIAHD008989Clinical Investigations of Inborn Errors of Metabolism42025

1 to 10 of 1,433Source NIH's project files

See all 1,433 nih grants

Papers2,338

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Characterizing Allergen Profiles and Identifying Group 2 Allergens of Three Storage Mites: Acarus siro, Chortoglyphus arcuatus and Carpoglyphus lactis.Clin Exp Allergy202642777786PubTator, text miningPubMed
Meta-analysis of NPC2-mediated cholesterol transport in human cancers as a prognostic biomarker with therapeutic implications.Cell Cycle202642775549PubTator, text miningPubMed
Clinical and molecular spectrum of Niemann-Pick disease type C patients in India.Front Pediatr202642761304PubTator, text miningPubMed
A novel mTORC1-NPC2 axis suppresses lipophagy and drives atherosclerotic plaque progression.Biochim Biophys Acta Mol Basis Dis202642716142PubTator, text miningPubMed
M6PR/IGF2R double-knockout supplies therapeutic sources for mucolipidosis II and Niemann-Pick C2.J Biol Chem202642665096PubTator, text miningPubMed
Revisiting the Association of Central Precocious Puberty with Neurovisceral Diseases owing to a Girl with Niemann-Pick Disease Type C.J Clin Res Pediatr Endocrinol202642613861PubTator, text miningPubMed
A novel tumor necrosis factor-alpha-targeting protein degrader for the treatment of acute liver failure.Int J Biol Macromol202642607909PubTator, text miningPubMed
XGBoost-SHAP Interpretable Modeling Identifies and Validates an Eight-Gene Biomarker for Hepatic Encephalopathy Risk Prediction in Cirrhosis.Int J Mol Sci202642589578PubTator, text miningPubMed
Development of an immune escape-related gene prognostic signature using integrated single-cell and bulk RNA sequencing for immune microenvironment profiling in thyroid cancer.Korean J Physiol Pharmacol202642581622PubTator, text miningPubMed
Chemerin and NPC2 produced from iPSC-derived Müller glial cells promote retinal ganglion cell regeneration.Exp Eye Res202642575299PubTator, text miningPubMed

1 to 10 of 2,338

See all 2,338 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10577

GET https://conductscience.org/api/genes/v1/10577/patents?page=2