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Gene · 10578

GNLY: granulysin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GNLY: granulysin. Genes, record 10578. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10578

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Gene

Symbol
GNLY
HGNC
Name
granulysin
HGNC
NCBI Gene ID
10578
NCBI Gene
HGNC ID
HGNC:4414
HGNC
Ensembl
ENSG00000115523
NCBI Gene
Aliases
D2S69E, LAG-2, LAG2, NKG5, TLA519
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22749Granulysin1451Ensembl, GeneID, HGNC

Source UniProt

Patents89

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192263P22749Espacenet
JP 2025147176 A2025-10-066077P22749Espacenet
JP 2025529142 A2025-09-046516P22749Espacenet
US 12371689 B22025-07-296516P22749Espacenet
JP 2025517970 A2025-06-122263P22749Espacenet
JP 2025028160 A2025-02-286077P22749Espacenet
KR 1020250010750 A2025-01-216077P22749Espacenet
JP 2024123008 A2024-09-106373P22749Espacenet
JP 2024109657 A2024-08-146084P22749Espacenet
JP 2024096708 A2024-07-175P22749Espacenet

1 to 10 of 89

See all 89 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,192

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGNLY papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award212025
P30CA008748Cancer Center Support Grant182025
R01AI022553Molecular Analysis of Host Immune Response in Leprosy142025
P30CA016672Cancer Center Support Grant122025
R01AR040312CD1-restricted T-cell Responses in Skin122025
P30AI110527Tennessee Center for AIDS Research (TN-CFAR)102025
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro102025
P51OD011132Emory National Primate Research Center82025
R01AR063759Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state82025
T32AI007290Molecular and Cellular Immunobiology82025

1 to 10 of 2,192Source NIH's project files

See all 2,192 nih grants

Papers3,745

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Fast and slow gene expression changes in blood following acute social stress.Brain Behav Immun Health202642824708PubTator, text miningPubMed
Single-cell RNA sequencing reveals compartment-specific immune and tumor cell states in a contiguous spinal metastasis.Neurooncol Adv202642757049PubTator, text miningPubMed
Single-Cell Profiling Links T-Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children.Allergy202642744607PubTator, text miningPubMed
Pre-transplant whole blood transcriptomic profiling identifies mRNAs linked to cirrhosis-associated immune dysfunction as candidate predictors of clinical outcomes after liver transplantation: an exploratory study.
Transpl Int202642729608PubTator, text miningPubMed
Single-cell RNA sequencing reveals distinct immune interaction networks in primary and reactivated HHV-6B infection.J Infect Dis202642682208PubTator, text miningPubMed
Transcriptomic Markers of Immunosenescence in Cynomolgus Macaques: A Pilot Study.Genes (Basel)202642650137PubTator, text miningPubMed
Menstruation is Associated With Cyclical Granulysin Peaks in Vaginal Secretions Despite Stable Expression by Cervicovaginal Immune Cells.Am J Reprod Immunol202642616268PubTator, text miningPubMed
Vγ9Vδ2 T cells in tuberculosis: protective immunity and translational perspectives.Front Immunol202642609836PubTator, text miningPubMed
Cytotoxic CD4+ T Cells in Visceral Leishmaniasis Patients.Parasite Immunol202642609202PubTator, text miningPubMed
Immunomodulatory effects of HUC-MSCs therapy: enhancing adaptive and innate immune responses in aging frailty.Front Immunol202642564874PubTator, text miningPubMed

1 to 10 of 3,745

See all 3,745 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10578

GET https://conductscience.org/api/genes/v1/10578/patents?page=2