Gene · 1058
CENPA: centromere protein A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CENPA: centromere protein A. Genes, record 1058. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1058
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49450 | Histone H3-like centromeric protein A | 140 | 36 | Ensembl, GeneID, HGNC |
Source UniProt
Patents42
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4698223 A2 | 2026-02-25 | 34 | P49450 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40823 | P49450 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5090 | P49450 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5090 | P49450 | Espacenet |
| US 11965885 B2 | 2024-04-23 | 34 | P49450 | Espacenet |
| US 11609237 B2 | 2023-03-21 | 22 | P49450 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 13877 | P49450 | Espacenet |
| JP 2022538760 A | 2022-09-06 | 1 | P49450 | Espacenet |
| US 11434535 B2 | 2022-09-06 | 1 | P49450 | Espacenet |
| JP 2022092366 A | 2022-06-22 | 666 | P49450 | Espacenet |
1 to 10 of 42
See all 42 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,970
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CENPA papers | Newest fiscal year |
|---|---|---|---|
| R01GM074728 | Mechanisms of Kinetochore Assembly | 29 | 2025 |
| ZIABC010413 | Human Artificial Chromosomes for Cancer Research and Functional Genomics | 22 | 2025 |
| ZIABC010822 | Molecular Determinants of Chromosome Transmission and Cell Cycle Regulation | 22 | 2025 |
| ZIABC011207 | Biomechanical properties of chromatin in cancer and normal cells | 22 | 2025 |
| R01GM074215 | Kinetochore Specification and Function | 16 | 2025 |
| ZIABC011209 | Formation of Centromeres in vivo | 16 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 14 | 2025 |
| R01HG010169 | Sequence resolution of complex human genome structural variation | 12 | 2025 |
| ZIABC011206 | Role of histone variants in aging and cancer | 12 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 10 | 2025 |
1 to 10 of 1,970Source NIH's project files
See all 1,970 nih grantsPapers3,913
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Bufalin targets CENPA-modulated glycolysis via PI3K/AKT in hepatocellular carcinoma: A bioinformatics, In Vitro and preliminary In Vivo evidence. | Mol Cell Endocrinol | 2027 | 42716419 | PubTator, text mining | PubMed |
| SET Interacts With CENP-A and HJURP to Ensure Proper Mitotic Progression in Human Cells. | Cell Biol Int | 2026 | 42813684 | PubTator, text mining | PubMed |
| Cryo-EM structures of CENP-A nucleosomes isolated from human cells. | Commun Biol | 2026 | 42811066 | PubTator, text mining | PubMed |
| Utility of an extended 12-autoantibody panel in systemic sclerosis: Clinical and prognostic implications in a real-life cohort. | Rev Clin Esp (Barc) | 2026 | 42772597 | PubTator, text mining | PubMed |
| Immune cell enrichment characteristics and related key genes in intrauterine adhesion: insights from RNA-sequencing analysis. | Syst Biol Reprod Med | 2026 | 42763899 | PubTator, text mining | PubMed |
| IGF2BP3 enhances paclitaxel resistance in bladder urothelial carcinoma by recognizing m6A-modified CENPA mRNA. | Med Oncol | 2026 | 42720822 | PubTator, text mining | PubMed |
| The CENP-A chaperone complex spatially organizes centromeres. | Sci Adv | 2026 | 42715337 | PubTator, text mining | PubMed |
| Two near-complete assemblies reveal R-subgenome structural and centromeric divergence associated with reproductive isolation in hexaploid triticale. | Imeta | 2026 | 42661838 | PubTator, text mining | PubMed |
| Integrated Mendelian Randomization and Single-Cell Transcriptomics Reveal T Cell Immune Mechanisms in Systemic Lupus Erythematosus-Bladder Cancer Comorbidity. | Life (Basel) | 2026 | 42653069 | PubTator, text mining | PubMed |
| Mammalian metaphase kinetochores are elastic and require condensin for robust structure and function. | J Cell Biol | 2026 | 42640254 | PubTator, text mining | PubMed |
1 to 10 of 3,913
See all 3,913 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1058
GET https://conductscience.org/api/genes/v1/1058/patents?page=2