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Gene · 1058

CENPA: centromere protein A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CENPA: centromere protein A. Genes, record 1058. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1058

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Gene

Symbol
CENPA
HGNC
Name
centromere protein A
HGNC
NCBI Gene ID
1058
NCBI Gene
HGNC ID
HGNC:1851
HGNC
Ensembl
ENSG00000115163
NCBI Gene
Aliases
CENP-A, CenH3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49450Histone H3-like centromeric protein A14036Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4698223 A22026-02-2534P49450Espacenet
JP 2026004568 A2026-01-1440823P49450Espacenet
EP 4641202 A22025-10-295090P49450Espacenet
KR 1020250017231 A2025-02-045090P49450Espacenet
US 11965885 B22024-04-2334P49450Espacenet
US 11609237 B22023-03-2122P49450Espacenet
US 11446398 B22022-09-2013877P49450Espacenet
JP 2022538760 A2022-09-061P49450Espacenet
US 11434535 B22022-09-061P49450Espacenet
JP 2022092366 A2022-06-22666P49450Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,970

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCENPA papersNewest fiscal year
R01GM074728Mechanisms of Kinetochore Assembly292025
ZIABC010413Human Artificial Chromosomes for Cancer Research and Functional Genomics222025
ZIABC010822Molecular Determinants of Chromosome Transmission and Cell Cycle Regulation222025
ZIABC011207Biomechanical properties of chromatin in cancer and normal cells222025
R01GM074215Kinetochore Specification and Function162025
ZIABC011209Formation of Centromeres in vivo162025
P30CA008748Cancer Center Support Grant142025
R01HG010169Sequence resolution of complex human genome structural variation122025
ZIABC011206Role of histone variants in aging and cancer122025
P30CA015704Cancer Center Support Grant102025

1 to 10 of 1,970Source NIH's project files

See all 1,970 nih grants

Papers3,913

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Bufalin targets CENPA-modulated glycolysis via PI3K/AKT in hepatocellular carcinoma: A bioinformatics, In Vitro and preliminary In Vivo evidence.Mol Cell Endocrinol202742716419PubTator, text miningPubMed
SET Interacts With CENP-A and HJURP to Ensure Proper Mitotic Progression in Human Cells.Cell Biol Int202642813684PubTator, text miningPubMed
Cryo-EM structures of CENP-A nucleosomes isolated from human cells.Commun Biol202642811066PubTator, text miningPubMed
Utility of an extended 12-autoantibody panel in systemic sclerosis: Clinical and prognostic implications in a real-life cohort.Rev Clin Esp (Barc)202642772597PubTator, text miningPubMed
Immune cell enrichment characteristics and related key genes in intrauterine adhesion: insights from RNA-sequencing analysis.Syst Biol Reprod Med202642763899PubTator, text miningPubMed
IGF2BP3 enhances paclitaxel resistance in bladder urothelial carcinoma by recognizing m6A-modified CENPA mRNA.Med Oncol202642720822PubTator, text miningPubMed
The CENP-A chaperone complex spatially organizes centromeres.Sci Adv202642715337PubTator, text miningPubMed
Two near-complete assemblies reveal R-subgenome structural and centromeric divergence associated with reproductive isolation in hexaploid triticale.Imeta202642661838PubTator, text miningPubMed
Integrated Mendelian Randomization and Single-Cell Transcriptomics Reveal T Cell Immune Mechanisms in Systemic Lupus Erythematosus-Bladder Cancer Comorbidity.Life (Basel)202642653069PubTator, text miningPubMed
Mammalian metaphase kinetochores are elastic and require condensin for robust structure and function.J Cell Biol202642640254PubTator, text miningPubMed

1 to 10 of 3,913

See all 3,913 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1058

GET https://conductscience.org/api/genes/v1/1058/patents?page=2