Gene · 10587
TXNRD2: thioredoxin reductase 2
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. TXNRD2: thioredoxin reductase 2. Genes, record 10587. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10587
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NNW7 | Thioredoxin reductase 2, mitochondrial | 524 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents3
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants921
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TXNRD2 papers | Newest fiscal year |
|---|---|---|---|
| R01EY022305 | NEIGHBORHOOD Consortium for POAG Genetics | 10 | 2025 |
| P30EY014104 | P30 Core Grant for Vision Research | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 4 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 4 | 2025 |
| R01MH099660 | Postnatal mechanisms of cognitive development in mice | 4 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 3 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| P30EY004068 | Core Grant for Vision Research | 3 | 2025 |
| T32ES012870 | Graduate and Postdoctoral Training in Environmental Health Science and Toxicology | 3 | 2025 |
1 to 10 of 921Source NIH's project files
See all 921 nih grantsPapers1,425
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Dysregulation of mitochondrial bioenergetics, RNA processing, and cellular stress responses in FUS-ALS: a multi-dataset transcriptomic perspective. | Neurol Sci | 2026 | 42782389 | PubTator, text mining | PubMed |
| Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in endothelial cells treated with TNFα. | Biochem Biophys Rep | 2026 | 42756083 | PubTator, text mining | PubMed |
| Genetic Architecture and Clinical Phenotypes of Primary Open-Angle Glaucoma: An Updated Review of Mendelian Genes, GWAS Loci, and Polygenic Risk. | Clin Ophthalmol | 2026 | 42751619 | PubTator, text mining | PubMed |
| A TrxR2-targeted photosensitizer for controlled mitochondrial protein degradation and pyroptosis activation. | Chem Commun (Camb) | 2026 | 42669405 | PubTator, text mining | PubMed |
| Genetic variation in oxidative stress and detoxification pathways associated with prostate cancer susceptibility: a pathway-based analysis. | Free Radic Biol Med | 2026 | 42660330 | PubTator, text mining | PubMed |
| Selenium-Related Genes Modulate Susceptibility to Parkinson's Disease Via Combination and SNCA-Interactive Effects Rather than Independent Effects: A Case-Control Study. | Biol Trace Elem Res | 2026 | 42658426 | PubTator, text mining | PubMed |
| Evidence from European ancestry genome-wide association studies and a case-control study suggests several selenoproteins are linked to a decreased risk of Alzheimer's disease. | J Alzheimers Dis | 2026 | 42593354 | PubTator, text mining | PubMed |
| Clinical features of hereditary adrenocortical unresponsiveness to adrenocorticotropin (HAUA) in Japan: from a nationwide questionnaire based survey. | Endocr J | 2026 | 42586722 | PubTator, text mining | PubMed |
| Familial glucocorticoid deficiency due to a novel TXNRD2 variant: expanding the spectrum of a rare genetic cause. | Front Endocrinol (Lausanne) | 2026 | 42290847 | PubTator, text mining | PubMed |
| The integrated analysis of PRDX3 in lung cancer: biomarker potential and therapeutic target prospects. | Respir Res | 2026 | 42092925 | PubTator, text mining | PubMed |
1 to 10 of 1,425
See all 1,425 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
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GET https://conductscience.org/api/genes/v1/10587/grants?page=2