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Gene · 1059

CENPB: centromere protein B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CENPB: centromere protein B. Genes, record 1059. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1059

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Gene

Symbol
CENPB
HGNC
Name
centromere protein B
HGNC
NCBI Gene ID
1059
NCBI Gene
HGNC ID
HGNC:1852
HGNC
Ensembl
ENSG00000125817
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07199Major centromere autoantigen B5994Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4698223 A22026-02-2535P07199Espacenet
JP 2026004568 A2026-01-1440824P07199Espacenet
EP 4650780 A22025-11-1910211P07199Espacenet
JP 2025517970 A2025-06-1210211P07199Espacenet
JP 2024530931 A2024-08-2733P07199Espacenet
EP 4380580 A22024-06-1233P07199Espacenet
KR 1020240083171 A2024-06-1133P07199Espacenet
US 11446398 B22022-09-2013879P07199Espacenet
JP 2022538760 A2022-09-0615P07199Espacenet
JP 2022077016 A2022-05-203P07199Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants931

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCENPB papersNewest fiscal year
ZIABC010413Human Artificial Chromosomes for Cancer Research and Functional Genomics182025
P30CA006973Regional Oncology Research Center112025
R01GM074728Mechanisms of Kinetochore Assembly72025
R35GM122475Cell Biological mechanisms of centromere drive62025
T32AR048522Multidisciplinary Rheumatology Training Program62025
ZIABC011207Biomechanical properties of chromatin in cancer and normal cells62025
P30CA036727Buffett Cancer Center Support Grant52025
R35GM122476Mechanisms of chromosome segregation, aneuploidy, and tumorigenesis52025
R35GM130302Centromere identity, strength, and regulation52025
T32CA009110Training in Areas Fundamental to Cancer Research52025

1 to 10 of 931Source NIH's project files

See all 931 nih grants

Papers1,705

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Utility of an extended 12-autoantibody panel in systemic sclerosis: Clinical and prognostic implications in a real-life cohort.Rev Clin Esp (Barc)202642772597PubTator, text miningPubMed
Diagnostic performance of antibodies against extractable nuclear antigens detected by immunoblot in the differentiation of connective tissue diseases.Allergol Immunopathol (Madr)202642760884PubTator, text miningPubMed
Autoantibodies in systemic sclerosis display a proinflammatory Fc glycosylation signature independent of systemic inflammation.J Autoimmun202642732745PubTator, text miningPubMed
Anti-centromere antibody positivity: a spectrum of clinical diagnoses and immunological patterns in a large patient cohort.Clin Rheumatol202642618734PubTator, text miningPubMed
In-depth evaluation of false-positive biological reactions in the syphilis serological diagnosis: a cross-sectional study with two sampling components.Front Cell Infect Microbiol202642591135PubTator, text miningPubMed
Diagnostic performance of Pictor's targeted proteomics assay for extractable nuclear antigens compared with commercial line immunoassay and addressable laser bead immunoassay platforms.J Immunol Methods202642456928PubTator, text miningPubMed
A case analysis of Gitelman syndrome complicated with Sjögren's disease.Front Med (Lausanne)202642404579PubTator, text miningPubMed
Rapid centromere turnover and the adaptive radiation of lemurs.bioRxiv202642239255PubTator, text miningPubMed
CENP-B: Cornerstone of Kinetochores in Centromeres of Human Chromosomes.Front Biosci (Landmark Ed)202642216547PubTator, text miningPubMed
MNGIE with TYMP and POLG variants presenting as decade-long capsule retention: A case report.Neurol Sci202642185572PubTator, text miningPubMed

1 to 10 of 1,705

See all 1,705 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1059

GET https://conductscience.org/api/genes/v1/1059/patents?page=2